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Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan.
J Allergy Clin Immunol. 1991 May; 87(5):1002-9.JA

Abstract

We performed a nationwide epidemiologic study of hypersensitivity pneumonitis (HP) in Japan by questionnaire and found that 835 cases of HP were recognized during the 1980s; 74.4% were summer-type HP, 8.1% farmer's lung, 4.3% ventilation pneumonitis, 4.1% bird fancier's lung, 2.3% other types, such as chemical worker's lung, and 6.8% of unknown causative agent. It was found that the CD4/CD8 ratios of bronchoalveolar lavage (BAL) lymphocytes were significantly different with the type of disease. The ratio was 0.6 +/- 0.1 (mean +/- SEM) in summer-type HP (N = 271), 4.4 +/- 0.7 in farmer's lung (N = 22), 1.6 +/- 0.3 in ventilation pneumonitis (N = 19), and 2.0 +/- 0.5 in bird fancier's lung (N = 19). In farmer's lung, the CD4/CD8 ratio in smokers was 6.2 +/- 1.9 (N = 6) in contrast with 3.4 +/- 0.7 for nonsmokers (N = 16) (p less than 0.05). It has been generally considered that the phenotypes of BAL lymphocytes in patients with HP are predominately CD8 cells. Our present results, however, indicate that the phenotypes of BAL lymphocytes vary with the type of HP, probably depending on factors such as causative agent, smoking, or staging of the disease.

Authors+Show Affiliations

First Department of Internal Medicine, Kumamoto University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1902851

Citation

Ando, M, et al. "Difference in the Phenotypes of Bronchoalveolar Lavage Lymphocytes in Patients With Summer-type Hypersensitivity Pneumonitis, Farmer's Lung, Ventilation Pneumonitis, and Bird Fancier's Lung: Report of a Nationwide Epidemiologic Study in Japan." The Journal of Allergy and Clinical Immunology, vol. 87, no. 5, 1991, pp. 1002-9.
Ando M, Konishi K, Yoneda R, et al. Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan. J Allergy Clin Immunol. 1991;87(5):1002-9.
Ando, M., Konishi, K., Yoneda, R., & Tamura, M. (1991). Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan. The Journal of Allergy and Clinical Immunology, 87(5), 1002-9.
Ando M, et al. Difference in the Phenotypes of Bronchoalveolar Lavage Lymphocytes in Patients With Summer-type Hypersensitivity Pneumonitis, Farmer's Lung, Ventilation Pneumonitis, and Bird Fancier's Lung: Report of a Nationwide Epidemiologic Study in Japan. J Allergy Clin Immunol. 1991;87(5):1002-9. PubMed PMID: 1902851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: report of a nationwide epidemiologic study in Japan. AU - Ando,M, AU - Konishi,K, AU - Yoneda,R, AU - Tamura,M, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 1002 EP - 9 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 87 IS - 5 N2 - We performed a nationwide epidemiologic study of hypersensitivity pneumonitis (HP) in Japan by questionnaire and found that 835 cases of HP were recognized during the 1980s; 74.4% were summer-type HP, 8.1% farmer's lung, 4.3% ventilation pneumonitis, 4.1% bird fancier's lung, 2.3% other types, such as chemical worker's lung, and 6.8% of unknown causative agent. It was found that the CD4/CD8 ratios of bronchoalveolar lavage (BAL) lymphocytes were significantly different with the type of disease. The ratio was 0.6 +/- 0.1 (mean +/- SEM) in summer-type HP (N = 271), 4.4 +/- 0.7 in farmer's lung (N = 22), 1.6 +/- 0.3 in ventilation pneumonitis (N = 19), and 2.0 +/- 0.5 in bird fancier's lung (N = 19). In farmer's lung, the CD4/CD8 ratio in smokers was 6.2 +/- 1.9 (N = 6) in contrast with 3.4 +/- 0.7 for nonsmokers (N = 16) (p less than 0.05). It has been generally considered that the phenotypes of BAL lymphocytes in patients with HP are predominately CD8 cells. Our present results, however, indicate that the phenotypes of BAL lymphocytes vary with the type of HP, probably depending on factors such as causative agent, smoking, or staging of the disease. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/1902851/Difference_in_the_phenotypes_of_bronchoalveolar_lavage_lymphocytes_in_patients_with_summer_type_hypersensitivity_pneumonitis_farmer's_lung_ventilation_pneumonitis_and_bird_fancier's_lung:_report_of_a_nationwide_epidemiologic_study_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(91)90423-L DB - PRIME DP - Unbound Medicine ER -