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Moderate alcohol disrupts a mechanism for detection of rare events in human visual cortex.
J Psychopharmacol. 2010 Jun; 24(6):839-45.JP

Abstract

Moderate doses of alcohol (blood alcohol concentration [BAC] of about 0.05%) may result in acute impairments at various levels of information processing. A number of reports have documented detrimental effects of moderate alcohol on the mismatch negativity (MMN), the electrocortical manifestation of a rapid (100 ms poststimulus) mechanism dedicated to the detection of unexpected auditory change (e.g., Jääskeläinen, et al., 1995). Recently, we and others identified a partial visual counterpart of the MMN, sometimes called the rareness-related negativity (RRN). Analogous to the MMN, the RRN evolves at about 100 ms after the unexpected change and was localized in visual cortex (Kenemans, et al., 2003). Rapid detection of unexpected events is important for everyday-life conditions like driving, prompting the question whether the visual RRN shows sensitivity to moderate alcohol similar to the MMN. In all, 16 subjects were tested either under moderate alcohol or under placebo. Unexpected visual change was implemented by presenting 2.4 versus 0.6 c/d gratings in pseudorandom sequences according to a deviant (10%)/standard (90%) schedule. The alcohol effects on MMN reported before were replicated. Furthermore, the RRN, defined as the difference between deviant and standard event-related potentials between 120 and 170 ms at Oz, was present under placebo but not under alcohol. It is concluded that moderate alcohol does indeed impair the rapid detection in visual cortex of unexpected changes. In contrast, electrocortical correlates of lower level sensory processing were still significantly present under alcohol.

Authors+Show Affiliations

Department of Experimental Psychology and Psychopharmacology, Utrecht University, The Netherlands. j.l.kenemans@uu.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19028837

Citation

Kenemans, J L., et al. "Moderate Alcohol Disrupts a Mechanism for Detection of Rare Events in Human Visual Cortex." Journal of Psychopharmacology (Oxford, England), vol. 24, no. 6, 2010, pp. 839-45.
Kenemans JL, Hebly W, van den Heuvel EH, et al. Moderate alcohol disrupts a mechanism for detection of rare events in human visual cortex. J Psychopharmacol. 2010;24(6):839-45.
Kenemans, J. L., Hebly, W., van den Heuvel, E. H., & Grent-'T-Jong, T. (2010). Moderate alcohol disrupts a mechanism for detection of rare events in human visual cortex. Journal of Psychopharmacology (Oxford, England), 24(6), 839-45. https://doi.org/10.1177/0269881108098868
Kenemans JL, et al. Moderate Alcohol Disrupts a Mechanism for Detection of Rare Events in Human Visual Cortex. J Psychopharmacol. 2010;24(6):839-45. PubMed PMID: 19028837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate alcohol disrupts a mechanism for detection of rare events in human visual cortex. AU - Kenemans,J L, AU - Hebly,W, AU - van den Heuvel,E H M, AU - Grent-'T-Jong,T, Y1 - 2008/11/21/ PY - 2008/11/26/pubmed PY - 2010/8/21/medline PY - 2008/11/26/entrez SP - 839 EP - 45 JF - Journal of psychopharmacology (Oxford, England) JO - J Psychopharmacol VL - 24 IS - 6 N2 - Moderate doses of alcohol (blood alcohol concentration [BAC] of about 0.05%) may result in acute impairments at various levels of information processing. A number of reports have documented detrimental effects of moderate alcohol on the mismatch negativity (MMN), the electrocortical manifestation of a rapid (100 ms poststimulus) mechanism dedicated to the detection of unexpected auditory change (e.g., Jääskeläinen, et al., 1995). Recently, we and others identified a partial visual counterpart of the MMN, sometimes called the rareness-related negativity (RRN). Analogous to the MMN, the RRN evolves at about 100 ms after the unexpected change and was localized in visual cortex (Kenemans, et al., 2003). Rapid detection of unexpected events is important for everyday-life conditions like driving, prompting the question whether the visual RRN shows sensitivity to moderate alcohol similar to the MMN. In all, 16 subjects were tested either under moderate alcohol or under placebo. Unexpected visual change was implemented by presenting 2.4 versus 0.6 c/d gratings in pseudorandom sequences according to a deviant (10%)/standard (90%) schedule. The alcohol effects on MMN reported before were replicated. Furthermore, the RRN, defined as the difference between deviant and standard event-related potentials between 120 and 170 ms at Oz, was present under placebo but not under alcohol. It is concluded that moderate alcohol does indeed impair the rapid detection in visual cortex of unexpected changes. In contrast, electrocortical correlates of lower level sensory processing were still significantly present under alcohol. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/19028837/Moderate_alcohol_disrupts_a_mechanism_for_detection_of_rare_events_in_human_visual_cortex_ L2 - https://journals.sagepub.com/doi/10.1177/0269881108098868?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -