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Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study.
Cancer Epidemiol Biomarkers Prev 2008; 17(12):3396-401CE

Abstract

PURPOSE

This study aimed to examine prospectively the association between physical activity and breast cancer risk in a non-Western population.

METHODS

We analyzed data from the Japan Collaborative Cohort Study, which included 30,157 women, ages 40 to 69 years at baseline (1988-1990), who reported no previous history of breast cancer, and provided information on their walking and exercise habits. The subjects were followed prospectively from enrollment until 2001 (median follow-up period, 12.4 years). Breast cancer incidence during this period was confirmed using records held at population-based cancer registries. The Cox proportional hazards model was used to estimate the hazard ratio (HR) for the association of breast cancer incidence with physical activity.

RESULTS

During the 340,055 person-years of follow-up, we identified 207 incident cases of breast cancer. The most physically active group (who walked for > or = 1 hour per day and exercised for > or = 1 hour per week) had a lower risk of breast cancer (HR, 0.45; 95% confidence interval, 0.25-0.78) compared with the least active group after adjusting for potential confounding factors. The inverse association of exercise on breast cancer was stronger among those who walked for > or = 1 hour per day than those who walked for <1 hour per day (P = 0.042). These results were not significantly modified by menopausal status or body mass index (BMI).

CONCLUSIONS

Our analysis provided evidence that physical activity decreased the risk of breast cancer. Walking for 1 hour per day and undertaking additional weekly exercise both seemed to be protective against breast cancer, regardless of menopausal status or BMI.

Authors+Show Affiliations

Department of Public Health, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. ssuzuki@med.nagoya-cu.ac.jp

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19029398

Citation

Suzuki, Sadao, et al. "Effect of Physical Activity On Breast Cancer Risk: Findings of the Japan Collaborative Cohort Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 12, 2008, pp. 3396-401.
Suzuki S, Kojima M, Tokudome S, et al. Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3396-401.
Suzuki, S., Kojima, M., Tokudome, S., Mori, M., Sakauchi, F., Fujino, Y., ... Tamakoshi, A. (2008). Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(12), pp. 3396-401. doi:10.1158/1055-9965.EPI-08-0497.
Suzuki S, et al. Effect of Physical Activity On Breast Cancer Risk: Findings of the Japan Collaborative Cohort Study. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3396-401. PubMed PMID: 19029398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. AU - Suzuki,Sadao, AU - Kojima,Masayo, AU - Tokudome,Shinkan, AU - Mori,Mitsuru, AU - Sakauchi,Fumio, AU - Fujino,Yoshihisa, AU - Wakai,Kenji, AU - Lin,Yingsong, AU - Kikuchi,Shogo, AU - Tamakoshi,Koji, AU - Yatsuya,Hiroshi, AU - Tamakoshi,Akiko, AU - ,, Y1 - 2008/11/24/ PY - 2008/11/26/pubmed PY - 2009/1/28/medline PY - 2008/11/26/entrez SP - 3396 EP - 401 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 12 N2 - PURPOSE: This study aimed to examine prospectively the association between physical activity and breast cancer risk in a non-Western population. METHODS: We analyzed data from the Japan Collaborative Cohort Study, which included 30,157 women, ages 40 to 69 years at baseline (1988-1990), who reported no previous history of breast cancer, and provided information on their walking and exercise habits. The subjects were followed prospectively from enrollment until 2001 (median follow-up period, 12.4 years). Breast cancer incidence during this period was confirmed using records held at population-based cancer registries. The Cox proportional hazards model was used to estimate the hazard ratio (HR) for the association of breast cancer incidence with physical activity. RESULTS: During the 340,055 person-years of follow-up, we identified 207 incident cases of breast cancer. The most physically active group (who walked for > or = 1 hour per day and exercised for > or = 1 hour per week) had a lower risk of breast cancer (HR, 0.45; 95% confidence interval, 0.25-0.78) compared with the least active group after adjusting for potential confounding factors. The inverse association of exercise on breast cancer was stronger among those who walked for > or = 1 hour per day than those who walked for <1 hour per day (P = 0.042). These results were not significantly modified by menopausal status or body mass index (BMI). CONCLUSIONS: Our analysis provided evidence that physical activity decreased the risk of breast cancer. Walking for 1 hour per day and undertaking additional weekly exercise both seemed to be protective against breast cancer, regardless of menopausal status or BMI. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/19029398/Effect_of_physical_activity_on_breast_cancer_risk:_findings_of_the_Japan_collaborative_cohort_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=19029398 DB - PRIME DP - Unbound Medicine ER -