Tags

Type your tag names separated by a space and hit enter

Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms.
World J Gastroenterol 2008; 14(42):6481-7WJ

Abstract

AIM

To determine the association of Helicobacter pylori (H pylori) CagA(+) infection and pro-inflammatory polymorphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer.

METHODS

Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 consecutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA(+) was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP) and PCR respectively.

RESULTS

In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA(+) status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA(+) (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 microg/L as well as PGI/PGII < 3.4 were associated with CagA(+).

CONCLUSION

In a dyspeptic population in Costa Rica, H pylori CagA(+) is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine polymorphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population.

Authors+Show Affiliations

Institute of Health Research, University of Costa Rica, San Jose 2060, Costa Rica.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19030199

Citation

Sierra, Rafaela, et al. "Relation of Atrophic Gastritis With Helicobacter pylori-CagA(+) and Interleukin-1 Gene Polymorphisms." World Journal of Gastroenterology, vol. 14, no. 42, 2008, pp. 6481-7.
Sierra R, Une C, Ramirez V, et al. Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms. World J Gastroenterol. 2008;14(42):6481-7.
Sierra, R., Une, C., Ramirez, V., Alpizar-Alpizar, W., Gonzalez, M. I., Ramirez, J. A., ... Megraud, F. (2008). Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms. World Journal of Gastroenterology, 14(42), pp. 6481-7.
Sierra R, et al. Relation of Atrophic Gastritis With Helicobacter pylori-CagA(+) and Interleukin-1 Gene Polymorphisms. World J Gastroenterol. 2008 Nov 14;14(42):6481-7. PubMed PMID: 19030199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms. AU - Sierra,Rafaela, AU - Une,Clas, AU - Ramirez,Vanessa, AU - Alpizar-Alpizar,Warner, AU - Gonzalez,Maria-I, AU - Ramirez,Jose-A, AU - De Mascarel,Antoine, AU - Cuenca,Patricia, AU - Perez-Perez,Guillermo, AU - Megraud,Francis, PY - 2008/11/26/pubmed PY - 2009/4/3/medline PY - 2008/11/26/entrez SP - 6481 EP - 7 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 14 IS - 42 N2 - AIM: To determine the association of Helicobacter pylori (H pylori) CagA(+) infection and pro-inflammatory polymorphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 consecutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA(+) was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP) and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA(+) status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA(+) (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 microg/L as well as PGI/PGII < 3.4 were associated with CagA(+). CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA(+) is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine polymorphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/19030199/Relation_of_atrophic_gastritis_with_Helicobacter_pylori_CagA_+__and_interleukin_1_gene_polymorphisms_ L2 - http://www.wjgnet.com/1007-9327/full/v14/i42/6481.htm DB - PRIME DP - Unbound Medicine ER -