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Serum adiponectin during pregnancy and postpartum in women with gestational diabetes and normal controls.
Gynecol Endocrinol. 2008 Nov; 24(11):614-9.GE

Abstract

AIMS

To investigate changes in serum adiponectin during pregnancy and postpartum and assess its relationship with insulin resistance as measured by homeostasis model assessment (HOMA-IR).

METHODS

Twenty-two normal pregnant women were compared with 22 women diagnosed with gestational diabetes mellitus (GDM). Serum adiponectin levels were measured at the time of the glucose challenge test as well as in the immediate postpartum period and the correlation of adiponectin to HOMA-IR was performed.

RESULTS

Adiponectin was significantly lower in women with GDM than in controls during pregnancy (5381 vs. 8449 ng/dl, p = 0.004), as well as postpartum (3278 vs. 6958 ng/ml, p = 0.002). A significant reduction in adiponectin (3278 vs. 5381 ng/ml, p = 0.002) was observed postpartum in GDM women but not in controls. Using a lower cut-off value of 5253 ng/ml, maternal adiponectin could exclude GDM with a sensitivity of 86.4% and a specificity of 59.1% (area under the curve = 0.752, standard error = 0.77, 95% confidence interval 0.601-0.903, p = 0.004). Adiponectin levels during pregnancy were negatively correlated with HOMA-IR (r = -0.375, p = 0.012).

CONCLUSION

GDM is associated with decreased serum adiponectin levels both in pregnancy as well as postpartum. Adiponectin is negatively correlated to HOMA-IR. A reduction in maternal adiponectin after delivery indicates a significant placental contribution to adiponectin production.

Authors+Show Affiliations

Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19031217

Citation

Vitoratos, Nikolaos, et al. "Serum Adiponectin During Pregnancy and Postpartum in Women With Gestational Diabetes and Normal Controls." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 11, 2008, pp. 614-9.
Vitoratos N, Deliveliotou A, Vlahos NF, et al. Serum adiponectin during pregnancy and postpartum in women with gestational diabetes and normal controls. Gynecol Endocrinol. 2008;24(11):614-9.
Vitoratos, N., Deliveliotou, A., Vlahos, N. F., Mastorakos, G., Papadias, K., Botsis, D., & Creatsas, G. K. (2008). Serum adiponectin during pregnancy and postpartum in women with gestational diabetes and normal controls. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(11), 614-9. https://doi.org/10.1080/09513590802342866
Vitoratos N, et al. Serum Adiponectin During Pregnancy and Postpartum in Women With Gestational Diabetes and Normal Controls. Gynecol Endocrinol. 2008;24(11):614-9. PubMed PMID: 19031217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum adiponectin during pregnancy and postpartum in women with gestational diabetes and normal controls. AU - Vitoratos,Nikolaos, AU - Deliveliotou,Aikaterini, AU - Vlahos,Nikos F, AU - Mastorakos,George, AU - Papadias,Konstantinos, AU - Botsis,Dimitrios, AU - Creatsas,George K, PY - 2008/11/26/pubmed PY - 2009/2/20/medline PY - 2008/11/26/entrez SP - 614 EP - 9 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 24 IS - 11 N2 - AIMS: To investigate changes in serum adiponectin during pregnancy and postpartum and assess its relationship with insulin resistance as measured by homeostasis model assessment (HOMA-IR). METHODS: Twenty-two normal pregnant women were compared with 22 women diagnosed with gestational diabetes mellitus (GDM). Serum adiponectin levels were measured at the time of the glucose challenge test as well as in the immediate postpartum period and the correlation of adiponectin to HOMA-IR was performed. RESULTS: Adiponectin was significantly lower in women with GDM than in controls during pregnancy (5381 vs. 8449 ng/dl, p = 0.004), as well as postpartum (3278 vs. 6958 ng/ml, p = 0.002). A significant reduction in adiponectin (3278 vs. 5381 ng/ml, p = 0.002) was observed postpartum in GDM women but not in controls. Using a lower cut-off value of 5253 ng/ml, maternal adiponectin could exclude GDM with a sensitivity of 86.4% and a specificity of 59.1% (area under the curve = 0.752, standard error = 0.77, 95% confidence interval 0.601-0.903, p = 0.004). Adiponectin levels during pregnancy were negatively correlated with HOMA-IR (r = -0.375, p = 0.012). CONCLUSION: GDM is associated with decreased serum adiponectin levels both in pregnancy as well as postpartum. Adiponectin is negatively correlated to HOMA-IR. A reduction in maternal adiponectin after delivery indicates a significant placental contribution to adiponectin production. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19031217/Serum_adiponectin_during_pregnancy_and_postpartum_in_women_with_gestational_diabetes_and_normal_controls_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802342866 DB - PRIME DP - Unbound Medicine ER -