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Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index.
Gynecol Endocrinol. 2008 Nov; 24(11):620-4.GE

Abstract

BACKGROUND

Since current clinical evidence indicates that conventional estrogen hormone therapy (HT) increases cardiovascular risk, alternatives to estrogens are growing in popularity, especially among high-risk populations.

OBJECTIVE

To determine the effect of Trifolium pratense-derived isoflavone supplementation on the lipid profile of postmenopausal women with increased body mass index (BMI).

METHODS

Sixty postmenopausal women aged > 40 years, HT non-users, were randomly assigned to one of two groups: either two capsules of T. pratense (80 mg red clover isoflavones) daily for a 90-day period or placebo of equal design. After a 7-day washout period, medication was crossed-over for another 90 days. Total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C) and lipoprotein A (LpA) levels were assessed at baseline, 90 and 180 days. Women were divided into two groups: those with increased BMI (>or=25 kg/m(2)) and those with BMI < 25 kg/m(2).

RESULTS

Fifty-three women (88.3%) completed the trial. T. pratense isoflavone supplementation had a positive effect on the lipid profile of women with increased BMI, evidenced by a significant decrease in TC, LDL-C and LpA levels.

CONCLUSIONS

Isoflavones derived from T. pratense are an attractive alternative therapeutic option for high-risk populations such as postmenopausal women with increased BMI and abnormal lipid profile.

Authors+Show Affiliations

Institute of Biomedicine, Facultad de Ciencias Medicas, Universidad Catolica de Santiago de Guayaquil, Guayaquil, Ecuador. peterchedraui@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19031218

Citation

Chedraui, Peter, et al. "Effect of Trifolium Pratense-derived Isoflavones On the Lipid Profile of Postmenopausal Women With Increased Body Mass Index." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 11, 2008, pp. 620-4.
Chedraui P, San Miguel G, Hidalgo L, et al. Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index. Gynecol Endocrinol. 2008;24(11):620-4.
Chedraui, P., San Miguel, G., Hidalgo, L., Morocho, N., & Ross, S. (2008). Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(11), 620-4. https://doi.org/10.1080/09513590802288283
Chedraui P, et al. Effect of Trifolium Pratense-derived Isoflavones On the Lipid Profile of Postmenopausal Women With Increased Body Mass Index. Gynecol Endocrinol. 2008;24(11):620-4. PubMed PMID: 19031218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index. AU - Chedraui,Peter, AU - San Miguel,Glenda, AU - Hidalgo,Luis, AU - Morocho,Nancy, AU - Ross,Susana, PY - 2008/11/26/pubmed PY - 2009/2/20/medline PY - 2008/11/26/entrez SP - 620 EP - 4 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 24 IS - 11 N2 - BACKGROUND: Since current clinical evidence indicates that conventional estrogen hormone therapy (HT) increases cardiovascular risk, alternatives to estrogens are growing in popularity, especially among high-risk populations. OBJECTIVE: To determine the effect of Trifolium pratense-derived isoflavone supplementation on the lipid profile of postmenopausal women with increased body mass index (BMI). METHODS: Sixty postmenopausal women aged > 40 years, HT non-users, were randomly assigned to one of two groups: either two capsules of T. pratense (80 mg red clover isoflavones) daily for a 90-day period or placebo of equal design. After a 7-day washout period, medication was crossed-over for another 90 days. Total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C) and lipoprotein A (LpA) levels were assessed at baseline, 90 and 180 days. Women were divided into two groups: those with increased BMI (>or=25 kg/m(2)) and those with BMI < 25 kg/m(2). RESULTS: Fifty-three women (88.3%) completed the trial. T. pratense isoflavone supplementation had a positive effect on the lipid profile of women with increased BMI, evidenced by a significant decrease in TC, LDL-C and LpA levels. CONCLUSIONS: Isoflavones derived from T. pratense are an attractive alternative therapeutic option for high-risk populations such as postmenopausal women with increased BMI and abnormal lipid profile. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19031218/Effect_of_Trifolium_pratense_derived_isoflavones_on_the_lipid_profile_of_postmenopausal_women_with_increased_body_mass_index_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802288283 DB - PRIME DP - Unbound Medicine ER -