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Cortisol in burnout and vital exhaustion: an overview.
G Ital Med Lav Ergon. 2006 Jan-Mar; 28(1 Suppl 1):34-42.GI

Abstract

In this overview, we summarize findings on hypothalamus-pituitary-adrenal (HPA) axis functioning in burned out and (vitally) exhausted though otherwise healthy subjects as well as clinically diagnosed patients. The main focus will be on basal diurnal free cortisol regulation and cortisol responses to acute psychological stress. First, we describe normal HPA axis regulation as well as dysfunction which manifests in hyper- or hypoactivity. We also briefly illustrate three established methods to assess HPA axis activity, reactivity, and feedback functioning, namely the cortisol awakening rise (CAR), Trier Social Stress Test (TSST), and low-dose Dexamethasone Suppression Test (DST). Then, an up-to-date summary of empirical findings on the relationship between burnout, respectively vital exhaustion, and cortisol is provided including field as well as laboratory studies. Finally, we briefly discuss possible methodologically confounders and speculate on underlying mechanisms explaining, at least in part, how burnout and vital exhaustion might relate to disease vulnerability.

Authors+Show Affiliations

Kudielka BM
Department of Theoretical and Clinical Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. kudielka@uni-trier.de
Bellingrath S
No affiliation info available
Hellhammer DH
No affiliation info available

MeSH

Burnout, ProfessionalHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemStress, Psychological

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19031555

Citation

Kudielka, B M., et al. "Cortisol in Burnout and Vital Exhaustion: an Overview." Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, vol. 28, no. 1 Suppl 1, 2006, pp. 34-42.
Kudielka BM, Bellingrath S, Hellhammer DH. Cortisol in burnout and vital exhaustion: an overview. G Ital Med Lav Ergon. 2006;28(1 Suppl 1):34-42.
Kudielka, B. M., Bellingrath, S., & Hellhammer, D. H. (2006). Cortisol in burnout and vital exhaustion: an overview. Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 28(1 Suppl 1), 34-42.
Kudielka BM, Bellingrath S, Hellhammer DH. Cortisol in Burnout and Vital Exhaustion: an Overview. G Ital Med Lav Ergon. 2006 Jan-Mar;28(1 Suppl 1):34-42. PubMed PMID: 19031555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cortisol in burnout and vital exhaustion: an overview. AU - Kudielka,B M, AU - Bellingrath,S, AU - Hellhammer,D H, PY - 2008/11/26/pubmed PY - 2009/3/6/medline PY - 2008/11/26/entrez SP - 34 EP - 42 JF - Giornale italiano di medicina del lavoro ed ergonomia JO - G Ital Med Lav Ergon VL - 28 IS - 1 Suppl 1 N2 - In this overview, we summarize findings on hypothalamus-pituitary-adrenal (HPA) axis functioning in burned out and (vitally) exhausted though otherwise healthy subjects as well as clinically diagnosed patients. The main focus will be on basal diurnal free cortisol regulation and cortisol responses to acute psychological stress. First, we describe normal HPA axis regulation as well as dysfunction which manifests in hyper- or hypoactivity. We also briefly illustrate three established methods to assess HPA axis activity, reactivity, and feedback functioning, namely the cortisol awakening rise (CAR), Trier Social Stress Test (TSST), and low-dose Dexamethasone Suppression Test (DST). Then, an up-to-date summary of empirical findings on the relationship between burnout, respectively vital exhaustion, and cortisol is provided including field as well as laboratory studies. Finally, we briefly discuss possible methodologically confounders and speculate on underlying mechanisms explaining, at least in part, how burnout and vital exhaustion might relate to disease vulnerability. SN - 1592-7830 UR - https://www.unboundmedicine.com/medline/citation/19031555/Cortisol_in_burnout_and_vital_exhaustion:_an_overview_ L2 - https://medlineplus.gov/stress.html DB - PRIME DP - Unbound Medicine ER -