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Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section*.
Anaesthesia 2008; 63(12):1319-26A

Abstract

SUMMARY

In a randomised, double-blinded study, we compared boluses of phenylephrine 100 microg with ephedrine 10 mg for treating hypotension (systolic blood pressure < 100 mmHg) in 204 patients having non-elective Caesarean section under spinal anaesthesia. Umbilical arterial (UA) and venous (UV) pH and base excess were similar between groups. In the ephedrine group, UA lactate concentration was higher (median 2.6 [interquartile range 2.3-3.3] vs 2.4 [1.9-3.0] mmolxl(-1), p = 0.002) and UV lactate concentration was higher (2.5 [2.2-3.2] vs 2.3 [1.9-2.8] mmolxl(-1), p = 0.016) and more patients had nausea or vomiting (12.7% vs 3.9%, p = 0.02). Clinical neonatal outcome was similar. Of the protocol-compliant patients (n = 148), UA Po(2) and UV Po(2) were lower in the phenylephrine group although oxygen content was similar. We conclude that phenylephrine and ephedrine are both suitable vasopressors for use in non-elective Caesarean sections.

Authors+Show Affiliations

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China. warwick@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19032300

Citation

Ngan Kee, W D., et al. "Randomised Double-blinded Comparison of Phenylephrine Vs Ephedrine for Maintaining Blood Pressure During Spinal Anaesthesia for Non-elective Caesarean Section*." Anaesthesia, vol. 63, no. 12, 2008, pp. 1319-26.
Ngan Kee WD, Khaw KS, Lau TK, et al. Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section*. Anaesthesia. 2008;63(12):1319-26.
Ngan Kee, W. D., Khaw, K. S., Lau, T. K., Ng, F. F., Chui, K., & Ng, K. L. (2008). Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section*. Anaesthesia, 63(12), pp. 1319-26. doi:10.1111/j.1365-2044.2008.05635.x.
Ngan Kee WD, et al. Randomised Double-blinded Comparison of Phenylephrine Vs Ephedrine for Maintaining Blood Pressure During Spinal Anaesthesia for Non-elective Caesarean Section*. Anaesthesia. 2008;63(12):1319-26. PubMed PMID: 19032300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section*. AU - Ngan Kee,W D, AU - Khaw,K S, AU - Lau,T K, AU - Ng,F F, AU - Chui,K, AU - Ng,K L, PY - 2008/11/27/pubmed PY - 2008/12/24/medline PY - 2008/11/27/entrez SP - 1319 EP - 26 JF - Anaesthesia JO - Anaesthesia VL - 63 IS - 12 N2 - SUMMARY: In a randomised, double-blinded study, we compared boluses of phenylephrine 100 microg with ephedrine 10 mg for treating hypotension (systolic blood pressure < 100 mmHg) in 204 patients having non-elective Caesarean section under spinal anaesthesia. Umbilical arterial (UA) and venous (UV) pH and base excess were similar between groups. In the ephedrine group, UA lactate concentration was higher (median 2.6 [interquartile range 2.3-3.3] vs 2.4 [1.9-3.0] mmolxl(-1), p = 0.002) and UV lactate concentration was higher (2.5 [2.2-3.2] vs 2.3 [1.9-2.8] mmolxl(-1), p = 0.016) and more patients had nausea or vomiting (12.7% vs 3.9%, p = 0.02). Clinical neonatal outcome was similar. Of the protocol-compliant patients (n = 148), UA Po(2) and UV Po(2) were lower in the phenylephrine group although oxygen content was similar. We conclude that phenylephrine and ephedrine are both suitable vasopressors for use in non-elective Caesarean sections. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/19032300/Randomised_double_blinded_comparison_of_phenylephrine_vs_ephedrine_for_maintaining_blood_pressure_during_spinal_anaesthesia_for_non_elective_Caesarean_section__ L2 - https://doi.org/10.1111/j.1365-2044.2008.05635.x DB - PRIME DP - Unbound Medicine ER -