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Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants.
Clin Exp Allergy. 2009 Feb; 39(2):254-60.CE

Abstract

BACKGROUND

The increase in incidence of atopic diseases (ADs) in the developed world over the past decades has been associated with reduced exposure of childhood infections.

OBJECTIVE

To investigate the relation between early intestinal viral infections in relation to the development of atopic symptoms (eczema, wheeze and atopic sensitization) in the first and second year(s) of life.

METHODS

In the KOALA Birth Cohort Study, we assessed IgG seropositivity for rota- and norovirus (GGI.1 and GGII.4) at 1 year of age. This was related to allergic sensitization [specific immunoglobulin E (IgE)] at 1 and 2 years, and parent reported eczema and wheeze in the first 2 years, using logistic regression analysis adjusted for confounders.

RESULTS

Rotavirus seropositivity (39%) was associated with an unexpected higher risk of recurrent wheeze in the first and second year of life [adjusted odds ratio (OR) 3.1 and 95% confidence intervals (CI) 1.1-9.1] and persistent and new recurrent wheeze (adjusted OR 2.7 and 95% CI 1.1-6.2). No further associations were found between intestinal viral seropositivity and atopic manifestations.

CONCLUSION

Our data did not show a clear protection by enteric viral infections in young children on development of IgE response to allergens, but rotavirus infection in the first year was a risk factor for wheeze. However, this needs to be followed up to older ages in order to establish the true importance of intestinal viral infections and especially cumulative effects in AD aetiology. Exposure to rotavirus may offer a new and interesting focus on infant wheeze and later asthma development.

Authors+Show Affiliations

Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment (RIVM), Bilthoven, Maastricht, Amsterdam, The Netherlands. johan.reimerink@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19032360

Citation

Reimerink, J, et al. "Early-life Rotavirus and Norovirus Infections in Relation to Development of Atopic Manifestation in Infants." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 39, no. 2, 2009, pp. 254-60.
Reimerink J, Stelma F, Rockx B, et al. Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants. Clin Exp Allergy. 2009;39(2):254-60.
Reimerink, J., Stelma, F., Rockx, B., Brouwer, D., Stobberingh, E., van Ree, R., Dompeling, E., Mommers, M., Thijs, C., & Koopmans, M. (2009). Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 39(2), 254-60. https://doi.org/10.1111/j.1365-2222.2008.03128.x
Reimerink J, et al. Early-life Rotavirus and Norovirus Infections in Relation to Development of Atopic Manifestation in Infants. Clin Exp Allergy. 2009;39(2):254-60. PubMed PMID: 19032360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants. AU - Reimerink,J, AU - Stelma,F, AU - Rockx,B, AU - Brouwer,D, AU - Stobberingh,E, AU - van Ree,R, AU - Dompeling,E, AU - Mommers,M, AU - Thijs,C, AU - Koopmans,M, Y1 - 2008/11/17/ PY - 2008/11/27/pubmed PY - 2009/3/31/medline PY - 2008/11/27/entrez SP - 254 EP - 60 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 39 IS - 2 N2 - BACKGROUND: The increase in incidence of atopic diseases (ADs) in the developed world over the past decades has been associated with reduced exposure of childhood infections. OBJECTIVE: To investigate the relation between early intestinal viral infections in relation to the development of atopic symptoms (eczema, wheeze and atopic sensitization) in the first and second year(s) of life. METHODS: In the KOALA Birth Cohort Study, we assessed IgG seropositivity for rota- and norovirus (GGI.1 and GGII.4) at 1 year of age. This was related to allergic sensitization [specific immunoglobulin E (IgE)] at 1 and 2 years, and parent reported eczema and wheeze in the first 2 years, using logistic regression analysis adjusted for confounders. RESULTS: Rotavirus seropositivity (39%) was associated with an unexpected higher risk of recurrent wheeze in the first and second year of life [adjusted odds ratio (OR) 3.1 and 95% confidence intervals (CI) 1.1-9.1] and persistent and new recurrent wheeze (adjusted OR 2.7 and 95% CI 1.1-6.2). No further associations were found between intestinal viral seropositivity and atopic manifestations. CONCLUSION: Our data did not show a clear protection by enteric viral infections in young children on development of IgE response to allergens, but rotavirus infection in the first year was a risk factor for wheeze. However, this needs to be followed up to older ages in order to establish the true importance of intestinal viral infections and especially cumulative effects in AD aetiology. Exposure to rotavirus may offer a new and interesting focus on infant wheeze and later asthma development. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/19032360/Early_life_rotavirus_and_norovirus_infections_in_relation_to_development_of_atopic_manifestation_in_infants_ L2 - https://doi.org/10.1111/j.1365-2222.2008.03128.x DB - PRIME DP - Unbound Medicine ER -