Tags

Type your tag names separated by a space and hit enter

Phytochemical and genetic analyses of ancient cannabis from Central Asia.
J Exp Bot 2008; 59(15):4171-82JE

Abstract

The Yanghai Tombs near Turpan, Xinjiang-Uighur Autonomous Region, China have recently been excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions. A multidisciplinary international team demonstrated through botanical examination, phytochemical investigation, and genetic deoxyribonucleic acid analysis by polymerase chain reaction that this material contained tetrahydrocannabinol, the psychoactive component of cannabis, its oxidative degradation product, cannabinol, other metabolites, and its synthetic enzyme, tetrahydrocannabinolic acid synthase, as well as a novel genetic variant with two single nucleotide polymorphisms. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. To our knowledge, these investigations provide the oldest documentation of cannabis as a pharmacologically active agent, and contribute to the medical and archaeological record of this pre-Silk Road culture.

Authors+Show Affiliations

Institute of Botany, Chinese Academy of Sciences. erusso@gwpharm.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19036842

Citation

Russo, Ethan B., et al. "Phytochemical and Genetic Analyses of Ancient Cannabis From Central Asia." Journal of Experimental Botany, vol. 59, no. 15, 2008, pp. 4171-82.
Russo EB, Jiang HE, Li X, et al. Phytochemical and genetic analyses of ancient cannabis from Central Asia. J Exp Bot. 2008;59(15):4171-82.
Russo, E. B., Jiang, H. E., Li, X., Sutton, A., Carboni, A., del Bianco, F., ... Li, C. S. (2008). Phytochemical and genetic analyses of ancient cannabis from Central Asia. Journal of Experimental Botany, 59(15), pp. 4171-82. doi:10.1093/jxb/ern260.
Russo EB, et al. Phytochemical and Genetic Analyses of Ancient Cannabis From Central Asia. J Exp Bot. 2008;59(15):4171-82. PubMed PMID: 19036842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical and genetic analyses of ancient cannabis from Central Asia. AU - Russo,Ethan B, AU - Jiang,Hong-En, AU - Li,Xiao, AU - Sutton,Alan, AU - Carboni,Andrea, AU - del Bianco,Francesca, AU - Mandolino,Giuseppe, AU - Potter,David J, AU - Zhao,You-Xing, AU - Bera,Subir, AU - Zhang,Yong-Bing, AU - Lü,En-Guo, AU - Ferguson,David K, AU - Hueber,Francis, AU - Zhao,Liang-Cheng, AU - Liu,Chang-Jiang, AU - Wang,Yu-Fei, AU - Li,Cheng-Sen, PY - 2008/11/28/pubmed PY - 2009/1/1/medline PY - 2008/11/28/entrez SP - 4171 EP - 82 JF - Journal of experimental botany JO - J. Exp. Bot. VL - 59 IS - 15 N2 - The Yanghai Tombs near Turpan, Xinjiang-Uighur Autonomous Region, China have recently been excavated to reveal the 2700-year-old grave of a Caucasoid shaman whose accoutrements included a large cache of cannabis, superbly preserved by climatic and burial conditions. A multidisciplinary international team demonstrated through botanical examination, phytochemical investigation, and genetic deoxyribonucleic acid analysis by polymerase chain reaction that this material contained tetrahydrocannabinol, the psychoactive component of cannabis, its oxidative degradation product, cannabinol, other metabolites, and its synthetic enzyme, tetrahydrocannabinolic acid synthase, as well as a novel genetic variant with two single nucleotide polymorphisms. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. To our knowledge, these investigations provide the oldest documentation of cannabis as a pharmacologically active agent, and contribute to the medical and archaeological record of this pre-Silk Road culture. SN - 1460-2431 UR - https://www.unboundmedicine.com/medline/citation/19036842/abstract/Phytochemical_and_genetic_analyses_of_ancient_cannabis_from_Central_Asia_ L2 - https://academic.oup.com/jxb/article-lookup/doi/10.1093/jxb/ern260 DB - PRIME DP - Unbound Medicine ER -