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Ketone measurements using dipstick methodology in cats with diabetes mellitus.
J Small Anim Pract. 2009 Jan; 50(1):4-8.JS

Abstract

OBJECTIVES

To compare the results of urine and plasma ketone dip test in a group of diabetic cats with possible ketosis or ketoacidosis, using laboratory plasma beta-hydroxybutyrate measurements as the gold standard.

METHODS

According to clinical examinations, plasma beta-hydroxybutyrate measurements and venous blood gas analysis, 54 cats with diabetes mellitus were classified as non-ketotic (n=3), ketotic (n=40) or ketoacidotic (n=11). Plasma and urine acetoacetate concentrations were determined using urine reagent strips.

RESULTS

Although there was a significant positive correlation between blood and urine ketone measurements (r=0.695, P<0.001), the results differed significantly (Z=-3.494, P<0.001). Using the differential positive rates, the best cut-off value to detect cats with ketoacidosis was 1.5 mmol/l for urine and 4 mmol/l for plasma. The sensitivity/specificity was 82/95 per cent for urine and 100/88 per cent for plasma, respectively.

CLINICAL SIGNIFICANCE

The urine and plasma ketone dip tests have a different diagnostic accuracy, and results have to be interpreted differently. Because of its high sensitivity, the plasma ketone dip test performs better than the urine ketone dip test to identify cats with impending or established ketoacidosis.

Authors+Show Affiliations

Clinical Department of Small Animals and Horses, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna.No affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

19037889

Citation

Zeugswetter, F, and M Pagitz. "Ketone Measurements Using Dipstick Methodology in Cats With Diabetes Mellitus." The Journal of Small Animal Practice, vol. 50, no. 1, 2009, pp. 4-8.
Zeugswetter F, Pagitz M. Ketone measurements using dipstick methodology in cats with diabetes mellitus. J Small Anim Pract. 2009;50(1):4-8.
Zeugswetter, F., & Pagitz, M. (2009). Ketone measurements using dipstick methodology in cats with diabetes mellitus. The Journal of Small Animal Practice, 50(1), 4-8. https://doi.org/10.1111/j.1748-5827.2008.00657.x
Zeugswetter F, Pagitz M. Ketone Measurements Using Dipstick Methodology in Cats With Diabetes Mellitus. J Small Anim Pract. 2009;50(1):4-8. PubMed PMID: 19037889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ketone measurements using dipstick methodology in cats with diabetes mellitus. AU - Zeugswetter,F, AU - Pagitz,M, Y1 - 2008/11/13/ PY - 2008/11/29/pubmed PY - 2009/3/18/medline PY - 2008/11/29/entrez SP - 4 EP - 8 JF - The Journal of small animal practice JO - J Small Anim Pract VL - 50 IS - 1 N2 - OBJECTIVES: To compare the results of urine and plasma ketone dip test in a group of diabetic cats with possible ketosis or ketoacidosis, using laboratory plasma beta-hydroxybutyrate measurements as the gold standard. METHODS: According to clinical examinations, plasma beta-hydroxybutyrate measurements and venous blood gas analysis, 54 cats with diabetes mellitus were classified as non-ketotic (n=3), ketotic (n=40) or ketoacidotic (n=11). Plasma and urine acetoacetate concentrations were determined using urine reagent strips. RESULTS: Although there was a significant positive correlation between blood and urine ketone measurements (r=0.695, P<0.001), the results differed significantly (Z=-3.494, P<0.001). Using the differential positive rates, the best cut-off value to detect cats with ketoacidosis was 1.5 mmol/l for urine and 4 mmol/l for plasma. The sensitivity/specificity was 82/95 per cent for urine and 100/88 per cent for plasma, respectively. CLINICAL SIGNIFICANCE: The urine and plasma ketone dip tests have a different diagnostic accuracy, and results have to be interpreted differently. Because of its high sensitivity, the plasma ketone dip test performs better than the urine ketone dip test to identify cats with impending or established ketoacidosis. SN - 0022-4510 UR - https://www.unboundmedicine.com/medline/citation/19037889/Ketone_measurements_using_dipstick_methodology_in_cats_with_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1748-5827.2008.00657.x DB - PRIME DP - Unbound Medicine ER -