Tags

Type your tag names separated by a space and hit enter

Antibiotic use in the first year of life and risk of atopic disease in early childhood.
Clin Exp Allergy. 2008 Dec; 38(12):1921-8.CE

Abstract

BACKGROUND

Reduced post-natal microbial stimulation resulting from improvements in public health measures, smaller family size, and through increased antibiotic use has been postulated to account for the increasing prevalence of atopic diseases seen predominantly in developed countries.

OBJECTIVE

To investigate use of antibiotics in the first year of life and subsequent development of atopic disease in early childhood.

METHODS

A prospective birth cohort of 198 children at high atopic risk was recruited prenatally and followed for 5 years. Illnesses and antibiotic use were ascertained through daily diaries, and diagnoses of asthma and hayfever were collected by questionnaire interviews. The children were examined regularly for eczema, and atopic status was defined by skin prick tests and serum total IgE. The effect of antibiotic use on subsequent atopic disease was examined using logistic regression with propensity score adjustment.

RESULTS

54.0% (107/198) of children received at least one course of antibiotics, mainly for acute respiratory illnesses (ARI). Thirty-three percent (329/984) of the ARI involved the lower respiratory tract (LRI). Twenty-three percent (222/984) of ARI were treated with antibiotics, with LRI significantly more likely to receive antibiotics. Antibiotic use was associated with asthma (unadjusted odds ratio 2.3; 95% confidence interval 1.2-4.5; P=0.01) but this association was reduced after propensity score adjustment. No associations were found between antibiotic use and eczema, current wheeze, current asthma, atopic asthma, allergic rhinoconjunctivitis or atopy.

CONCLUSION

Although this was a small study, systematic and careful monitoring of ARI, antibiotic use, and asthma and atopic diseases did not indicate that receipt of antibiotics early in life led to subsequent asthma or atopy at 5 years.

Authors+Show Affiliations

Division of Clinical Sciences, Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Subiaco, WA, Australia. mercik@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19037966

Citation

Kusel, M M H., et al. "Antibiotic Use in the First Year of Life and Risk of Atopic Disease in Early Childhood." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 38, no. 12, 2008, pp. 1921-8.
Kusel MM, de Klerk N, Holt PG, et al. Antibiotic use in the first year of life and risk of atopic disease in early childhood. Clin Exp Allergy. 2008;38(12):1921-8.
Kusel, M. M., de Klerk, N., Holt, P. G., & Sly, P. D. (2008). Antibiotic use in the first year of life and risk of atopic disease in early childhood. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 38(12), 1921-8. https://doi.org/10.1111/j.1365-2222.2008.03138.x
Kusel MM, et al. Antibiotic Use in the First Year of Life and Risk of Atopic Disease in Early Childhood. Clin Exp Allergy. 2008;38(12):1921-8. PubMed PMID: 19037966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibiotic use in the first year of life and risk of atopic disease in early childhood. AU - Kusel,M M H, AU - de Klerk,N, AU - Holt,P G, AU - Sly,P D, PY - 2008/11/29/pubmed PY - 2009/2/12/medline PY - 2008/11/29/entrez SP - 1921 EP - 8 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 38 IS - 12 N2 - BACKGROUND: Reduced post-natal microbial stimulation resulting from improvements in public health measures, smaller family size, and through increased antibiotic use has been postulated to account for the increasing prevalence of atopic diseases seen predominantly in developed countries. OBJECTIVE: To investigate use of antibiotics in the first year of life and subsequent development of atopic disease in early childhood. METHODS: A prospective birth cohort of 198 children at high atopic risk was recruited prenatally and followed for 5 years. Illnesses and antibiotic use were ascertained through daily diaries, and diagnoses of asthma and hayfever were collected by questionnaire interviews. The children were examined regularly for eczema, and atopic status was defined by skin prick tests and serum total IgE. The effect of antibiotic use on subsequent atopic disease was examined using logistic regression with propensity score adjustment. RESULTS: 54.0% (107/198) of children received at least one course of antibiotics, mainly for acute respiratory illnesses (ARI). Thirty-three percent (329/984) of the ARI involved the lower respiratory tract (LRI). Twenty-three percent (222/984) of ARI were treated with antibiotics, with LRI significantly more likely to receive antibiotics. Antibiotic use was associated with asthma (unadjusted odds ratio 2.3; 95% confidence interval 1.2-4.5; P=0.01) but this association was reduced after propensity score adjustment. No associations were found between antibiotic use and eczema, current wheeze, current asthma, atopic asthma, allergic rhinoconjunctivitis or atopy. CONCLUSION: Although this was a small study, systematic and careful monitoring of ARI, antibiotic use, and asthma and atopic diseases did not indicate that receipt of antibiotics early in life led to subsequent asthma or atopy at 5 years. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/19037966/Antibiotic_use_in_the_first_year_of_life_and_risk_of_atopic_disease_in_early_childhood_ L2 - https://doi.org/10.1111/j.1365-2222.2008.03138.x DB - PRIME DP - Unbound Medicine ER -