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An in vitro study of the potency and stability of fortified ophthalmic antibiotic preparations.
Am J Ophthalmol 1991; 111(6):686-9AJ

Abstract

We studied the potency of fortified ophthalmic antibiotic preparations of cefazolin sodium (50 mg/ml) and tobramycin sulfate (15 mg/ml), as measured by the minimum inhibitory concentration, against Streptococcus pneumoniae and Pseudomonas aeruginosa, respectively. We also examined absorbance spectra, pH, and the effect of storage temperature on these fortified solutions to determine their stability over a four-week period. Cefazolin and tobramycin maintained a constant potency throughout the experiment. There was no difference in potency if the fortified solutions were stored at 4 C or 24 C. Cefazolin stored at 24 C exhibited changes in both its absorbance spectra and pH after seven days. Cefazolin stored at 4 C and tobramycin stored at 24 C and 4 C remained stable throughout the four-week period.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Louisville, Kentucky.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1903903

Citation

Bowe, B E., et al. "An in Vitro Study of the Potency and Stability of Fortified Ophthalmic Antibiotic Preparations." American Journal of Ophthalmology, vol. 111, no. 6, 1991, pp. 686-9.
Bowe BE, Snyder JW, Eiferman RA. An in vitro study of the potency and stability of fortified ophthalmic antibiotic preparations. Am J Ophthalmol. 1991;111(6):686-9.
Bowe, B. E., Snyder, J. W., & Eiferman, R. A. (1991). An in vitro study of the potency and stability of fortified ophthalmic antibiotic preparations. American Journal of Ophthalmology, 111(6), pp. 686-9.
Bowe BE, Snyder JW, Eiferman RA. An in Vitro Study of the Potency and Stability of Fortified Ophthalmic Antibiotic Preparations. Am J Ophthalmol. 1991 Jun 15;111(6):686-9. PubMed PMID: 1903903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An in vitro study of the potency and stability of fortified ophthalmic antibiotic preparations. AU - Bowe,B E, AU - Snyder,J W, AU - Eiferman,R A, PY - 1991/6/15/pubmed PY - 1991/6/15/medline PY - 1991/6/15/entrez SP - 686 EP - 9 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 111 IS - 6 N2 - We studied the potency of fortified ophthalmic antibiotic preparations of cefazolin sodium (50 mg/ml) and tobramycin sulfate (15 mg/ml), as measured by the minimum inhibitory concentration, against Streptococcus pneumoniae and Pseudomonas aeruginosa, respectively. We also examined absorbance spectra, pH, and the effect of storage temperature on these fortified solutions to determine their stability over a four-week period. Cefazolin and tobramycin maintained a constant potency throughout the experiment. There was no difference in potency if the fortified solutions were stored at 4 C or 24 C. Cefazolin stored at 24 C exhibited changes in both its absorbance spectra and pH after seven days. Cefazolin stored at 4 C and tobramycin stored at 24 C and 4 C remained stable throughout the four-week period. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/1903903/An_in_vitro_study_of_the_potency_and_stability_of_fortified_ophthalmic_antibiotic_preparations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(14)76770-4 DB - PRIME DP - Unbound Medicine ER -