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The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters.
Contraception. 2009 Jan; 79(1):15-23.C

Abstract

BACKGROUND

This study was conducted to compare the effects of two monophasic oral contraceptives (OCs) containing ethinyl estradiol (EE) 30 mcg+either chlormadinone acetate (CMA) 2 mg (Belara) or 0.15 mg desogestrel (Marvelon) on lipid, hormone and other relevant metabolic parameters.

STUDY DESIGN

Markers of lipid and carbohydrate metabolism, and reproductive hormone levels, were measured in 45 subjects randomly assigned to 6 months of treatment with one of the two OCs. The cortisol response to adrenocorticotrophic hormone (ACTH) stimulation was also evaluated.

RESULTS

In both treatment groups, triglycerides, high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) AI and Apo AII levels increased; low-density lipoprotein cholesterol (LDL-C) and the LDL-C/HDL-C ratio decreased; and total cholesterol and lipoprotein(a) were unchanged during treatment. Effects on HDL-C, Apo AI, LDL-C and the LDL-C/HDL-C ratio were more evident in the EE 30 mcg+CMA 2 mg group. Follicle-stimulating hormone, luteinizing hormone and androgen levels decreased and sex hormone-binding globulin levels increased in both groups. Both OCs increased basal cortisol levels and cortisol response to ACTH. Oral contraceptive did not have a clinically significant impact on carbohydrate metabolism.

CONCLUSIONS

Both low-dose monophasic OCs had comparable effects on lipid, hormone and metabolic parameters during six cycles of treatment in healthy female subjects. There was some evidence of a beneficial effect on atherogenic cardiovascular risk markers, which was slightly more pronounced with EE 30 mcg+CMA 2 mg.

Authors+Show Affiliations

Department of Gynaecology and Obstetrics, Clinic of Wetzlar-Braunfels, 35578 Wetzlar, Germany. ulrich.winkler@klinikum-wetzlar-braunfe.deNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19041436

Citation

Winkler, Ulrich H., and Roland Sudik. "The Effects of Two Monophasic Oral Contraceptives Containing 30 Mcg of Ethinyl Estradiol and Either 2 Mg of Chlormadinone Acetate or 0.15 Mg of Desogestrel On Lipid, Hormone and Metabolic Parameters." Contraception, vol. 79, no. 1, 2009, pp. 15-23.
Winkler UH, Sudik R. The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters. Contraception. 2009;79(1):15-23.
Winkler, U. H., & Sudik, R. (2009). The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters. Contraception, 79(1), 15-23. https://doi.org/10.1016/j.contraception.2008.08.011
Winkler UH, Sudik R. The Effects of Two Monophasic Oral Contraceptives Containing 30 Mcg of Ethinyl Estradiol and Either 2 Mg of Chlormadinone Acetate or 0.15 Mg of Desogestrel On Lipid, Hormone and Metabolic Parameters. Contraception. 2009;79(1):15-23. PubMed PMID: 19041436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of two monophasic oral contraceptives containing 30 mcg of ethinyl estradiol and either 2 mg of chlormadinone acetate or 0.15 mg of desogestrel on lipid, hormone and metabolic parameters. AU - Winkler,Ulrich H, AU - Sudik,Roland, Y1 - 2008/11/17/ PY - 2008/07/16/received PY - 2008/07/21/revised PY - 2008/08/18/accepted PY - 2008/12/2/pubmed PY - 2009/3/14/medline PY - 2008/12/2/entrez SP - 15 EP - 23 JF - Contraception JO - Contraception VL - 79 IS - 1 N2 - BACKGROUND: This study was conducted to compare the effects of two monophasic oral contraceptives (OCs) containing ethinyl estradiol (EE) 30 mcg+either chlormadinone acetate (CMA) 2 mg (Belara) or 0.15 mg desogestrel (Marvelon) on lipid, hormone and other relevant metabolic parameters. STUDY DESIGN: Markers of lipid and carbohydrate metabolism, and reproductive hormone levels, were measured in 45 subjects randomly assigned to 6 months of treatment with one of the two OCs. The cortisol response to adrenocorticotrophic hormone (ACTH) stimulation was also evaluated. RESULTS: In both treatment groups, triglycerides, high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) AI and Apo AII levels increased; low-density lipoprotein cholesterol (LDL-C) and the LDL-C/HDL-C ratio decreased; and total cholesterol and lipoprotein(a) were unchanged during treatment. Effects on HDL-C, Apo AI, LDL-C and the LDL-C/HDL-C ratio were more evident in the EE 30 mcg+CMA 2 mg group. Follicle-stimulating hormone, luteinizing hormone and androgen levels decreased and sex hormone-binding globulin levels increased in both groups. Both OCs increased basal cortisol levels and cortisol response to ACTH. Oral contraceptive did not have a clinically significant impact on carbohydrate metabolism. CONCLUSIONS: Both low-dose monophasic OCs had comparable effects on lipid, hormone and metabolic parameters during six cycles of treatment in healthy female subjects. There was some evidence of a beneficial effect on atherogenic cardiovascular risk markers, which was slightly more pronounced with EE 30 mcg+CMA 2 mg. SN - 1879-0518 UR - https://www.unboundmedicine.com/medline/citation/19041436/The_effects_of_two_monophasic_oral_contraceptives_containing_30_mcg_of_ethinyl_estradiol_and_either_2_mg_of_chlormadinone_acetate_or_0_15_mg_of_desogestrel_on_lipid_hormone_and_metabolic_parameters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(08)00427-7 DB - PRIME DP - Unbound Medicine ER -