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Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes.
Ophthalmology 2008; 115(12):2132-40O

Abstract

PURPOSE

To evaluate quantitatively the structural damage of the peripapillary retinal nerve fiber layer (RNFL) in eyes with disc hemorrhage (DH).

DESIGN

Prospective cross-sectional study.

PARTICIPANTS

Seventy patients with DH (70 eyes; mean age +/- standard deviation, 60.0+/-11.8 years) and 100 healthy control subjects (100 eyes; mean age +/- standard deviation, 57.7+/-8.0 years) were enrolled from the Glaucoma Clinic of Seoul National University Hospital.

METHODS

Normal eyes without DH (group 1: normal control group) served as controls. Eyes with DH were divided into the following groups: (1) eyes with a DH, accompanied by no visible RNFL defect according to red-free fundus photography and normal visual fields (group 2: DH only group); (2) eyes with a DH and a localized RNFL defect in the same quadrant, accompanied by normal visual fields (group 3: DH-preperimetric group); and (3) eyes with a DH and a localized RNFL defect in the same quadrant, accompanied by glaucomatous visual field defect in the corresponding hemifield location (group 4: DH-perimetric group). Optical coherence tomography (OCT)-measured RNFL thicknesses were compared.

MAIN OUTCOME MEASURES

Average and segmental (4 quadrants and 12 clock-hours) OCT-measured RNFL thicknesses.

RESULTS

The number of eyes in groups 1, 2, 3, and 4 was 100, 25, 22, and 23 eyes, respectively. The OCT-measured RNFL thickness was significantly different among the 4 groups in average RNFL thickness and in inferior, superior, and nasal quadrants (P<0.01, 1-way analysis of variance). On post hoc analysis, the eyes of groups 2 and 3 showed thinner average RNFL thickness than those of group 1, and the average RNFL thickness of group 4 was significantly lower than that of groups 2 and 3 (P<0.001, 1-way analysis of variance and Tukey's test). The OCT-measured RNFL thickness revealed a topographic relationship with the DH location.

CONCLUSIONS

Significant RNFL loss was already present in the DH only eyes with apparently normal RNFL configuration by red-free fundus photography, indicating that preperimetric changes of the RNFL are already present. These results suggest that OCT has the potential to detect subclinical or preperimetric RNFL loss in the eyes with DH.

FINANCIAL DISCLOSURE(S)

The authors have no proprietary or commercial interest in any of the materials discussed in this article.

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    Authors+Show Affiliations

    Jeoung JW
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
    Park KH
    No affiliation info available
    Kim JM
    No affiliation info available
    Kang SH
    No affiliation info available
    Kang JH
    No affiliation info available
    Kim TW
    No affiliation info available
    Kim DM
    No affiliation info available

    MeSH

    Cross-Sectional StudiesFemaleGlaucoma, Open-AngleHumansMaleMiddle AgedNerve FibersOcular HypertensionOptic DiskOptic Nerve DiseasesPhotographyProspective StudiesRetinal Ganglion CellsRetinal HemorrhageTomography, Optical CoherenceTonometry, OcularVisual AcuityVisual Field TestsVisual Fields

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19041474

    Citation

    Jeoung, Jin Wook, et al. "Optic Disc Hemorrhage May Be Associated With Retinal Nerve Fiber Loss in Otherwise Normal Eyes." Ophthalmology, vol. 115, no. 12, 2008, pp. 2132-40.
    Jeoung JW, Park KH, Kim JM, et al. Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes. Ophthalmology. 2008;115(12):2132-40.
    Jeoung, J. W., Park, K. H., Kim, J. M., Kang, S. H., Kang, J. H., Kim, T. W., & Kim, D. M. (2008). Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes. Ophthalmology, 115(12), pp. 2132-40. doi:10.1016/j.ophtha.2008.08.024.
    Jeoung JW, et al. Optic Disc Hemorrhage May Be Associated With Retinal Nerve Fiber Loss in Otherwise Normal Eyes. Ophthalmology. 2008;115(12):2132-40. PubMed PMID: 19041474.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Optic disc hemorrhage may be associated with retinal nerve fiber loss in otherwise normal eyes. AU - Jeoung,Jin Wook, AU - Park,Ki Ho, AU - Kim,Joon Mo, AU - Kang,Shin Hee, AU - Kang,Ja Heon, AU - Kim,Tae-Woo, AU - Kim,Dong Myung, PY - 2008/03/11/received PY - 2008/07/07/revised PY - 2008/08/08/accepted PY - 2008/12/2/pubmed PY - 2008/12/18/medline PY - 2008/12/2/entrez SP - 2132 EP - 40 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 12 N2 - PURPOSE: To evaluate quantitatively the structural damage of the peripapillary retinal nerve fiber layer (RNFL) in eyes with disc hemorrhage (DH). DESIGN: Prospective cross-sectional study. PARTICIPANTS: Seventy patients with DH (70 eyes; mean age +/- standard deviation, 60.0+/-11.8 years) and 100 healthy control subjects (100 eyes; mean age +/- standard deviation, 57.7+/-8.0 years) were enrolled from the Glaucoma Clinic of Seoul National University Hospital. METHODS: Normal eyes without DH (group 1: normal control group) served as controls. Eyes with DH were divided into the following groups: (1) eyes with a DH, accompanied by no visible RNFL defect according to red-free fundus photography and normal visual fields (group 2: DH only group); (2) eyes with a DH and a localized RNFL defect in the same quadrant, accompanied by normal visual fields (group 3: DH-preperimetric group); and (3) eyes with a DH and a localized RNFL defect in the same quadrant, accompanied by glaucomatous visual field defect in the corresponding hemifield location (group 4: DH-perimetric group). Optical coherence tomography (OCT)-measured RNFL thicknesses were compared. MAIN OUTCOME MEASURES: Average and segmental (4 quadrants and 12 clock-hours) OCT-measured RNFL thicknesses. RESULTS: The number of eyes in groups 1, 2, 3, and 4 was 100, 25, 22, and 23 eyes, respectively. The OCT-measured RNFL thickness was significantly different among the 4 groups in average RNFL thickness and in inferior, superior, and nasal quadrants (P<0.01, 1-way analysis of variance). On post hoc analysis, the eyes of groups 2 and 3 showed thinner average RNFL thickness than those of group 1, and the average RNFL thickness of group 4 was significantly lower than that of groups 2 and 3 (P<0.001, 1-way analysis of variance and Tukey's test). The OCT-measured RNFL thickness revealed a topographic relationship with the DH location. CONCLUSIONS: Significant RNFL loss was already present in the DH only eyes with apparently normal RNFL configuration by red-free fundus photography, indicating that preperimetric changes of the RNFL are already present. These results suggest that OCT has the potential to detect subclinical or preperimetric RNFL loss in the eyes with DH. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any of the materials discussed in this article. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19041474/Optic_disc_hemorrhage_may_be_associated_with_retinal_nerve_fiber_loss_in_otherwise_normal_eyes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)00818-X DB - PRIME DP - Unbound Medicine ER -