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Pesticide/environmental exposures and Parkinson's disease in East Texas.
J Agromedicine 2008; 13(1):37-48JA

Abstract

Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population.

Authors+Show Affiliations

Department of Occupational Health Sciences, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA. amanpreet.dhillon@uthct.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

19042691

Citation

Dhillon, Amanpreet S., et al. "Pesticide/environmental Exposures and Parkinson's Disease in East Texas." Journal of Agromedicine, vol. 13, no. 1, 2008, pp. 37-48.
Dhillon AS, Tarbutton GL, Levin JL, et al. Pesticide/environmental exposures and Parkinson's disease in East Texas. J Agromedicine. 2008;13(1):37-48.
Dhillon, A. S., Tarbutton, G. L., Levin, J. L., Plotkin, G. M., Lowry, L. K., Nalbone, J. T., & Shepherd, S. (2008). Pesticide/environmental exposures and Parkinson's disease in East Texas. Journal of Agromedicine, 13(1), pp. 37-48. doi:10.1080/10599240801986215.
Dhillon AS, et al. Pesticide/environmental Exposures and Parkinson's Disease in East Texas. J Agromedicine. 2008;13(1):37-48. PubMed PMID: 19042691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pesticide/environmental exposures and Parkinson's disease in East Texas. AU - Dhillon,Amanpreet S, AU - Tarbutton,G Lester, AU - Levin,Jeffrey L, AU - Plotkin,George M, AU - Lowry,Larry K, AU - Nalbone,J Torey, AU - Shepherd,Sara, PY - 2008/12/2/pubmed PY - 2008/12/30/medline PY - 2008/12/2/entrez SP - 37 EP - 48 JF - Journal of agromedicine JO - J Agromedicine VL - 13 IS - 1 N2 - Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population. SN - 1059-924X UR - https://www.unboundmedicine.com/medline/citation/19042691/Pesticide/environmental_exposures_and_Parkinson's_disease_in_East_Texas_ L2 - http://www.tandfonline.com/doi/full/10.1080/10599240801986215 DB - PRIME DP - Unbound Medicine ER -