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Periodic leg movements in Cheyne-Stokes respiration.
Eur Respir J. 2008 Dec; 32(6):1656-62.ER

Abstract

Periodic leg movements during sleep (PLMS) are repetitive jerks of the lower limbs. Their occurrence can be isolated or part of various sleep disorders, such as restless legs syndrome (RLS), narcolepsy and obstructive sleep apnoea. Dopamine agonists are very effective in suppressing PLMS in RLS from the first night of administration. PLMS are often associated with cortical and autonomic arousals and may contribute to sleep disruption. Herein, a case of association between PLMS, Cheyne-Stokes respiration (CSR) and severe insomnia is described. Repeated polysomnographic studies demonstrated a clear synchronisation between PLMS and hyperventilation episodes, and the complete recovery of CSR, sleep quality and PLMS during nocturnal ventilation. In the same patient, pharmacological treatment with a dopamine agonist was ineffective on both PLMS and CSR. These results suggest that periodic leg movements during sleep coupled with central breathing events, similar to those observed in conjunction with obstructive events, may have a different origin in terms of neurotransmitter and pathway implicated, compared with periodic leg movements during sleep in restless legs syndrome, and are resolved by treatment of the respiratory abnormalities.

Authors+Show Affiliations

Centre of Sleep Medicine, Dept of Neurology, Scientific Institute of San Raffaele, Vita-Salute University, Milan, Italy. manconi.mauro@hsr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19043012

Citation

Manconi, M, et al. "Periodic Leg Movements in Cheyne-Stokes Respiration." The European Respiratory Journal, vol. 32, no. 6, 2008, pp. 1656-62.
Manconi M, Vitale G, Ferri R, et al. Periodic leg movements in Cheyne-Stokes respiration. Eur Respir J. 2008;32(6):1656-62.
Manconi, M., Vitale, G., Ferri, R., Zucconi, M., & Ferini-Strambi, L. (2008). Periodic leg movements in Cheyne-Stokes respiration. The European Respiratory Journal, 32(6), 1656-62. https://doi.org/10.1183/09031936.00163507
Manconi M, et al. Periodic Leg Movements in Cheyne-Stokes Respiration. Eur Respir J. 2008;32(6):1656-62. PubMed PMID: 19043012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periodic leg movements in Cheyne-Stokes respiration. AU - Manconi,M, AU - Vitale,G, AU - Ferri,R, AU - Zucconi,M, AU - Ferini-Strambi,L, PY - 2008/12/2/pubmed PY - 2009/5/9/medline PY - 2008/12/2/entrez SP - 1656 EP - 62 JF - The European respiratory journal JO - Eur Respir J VL - 32 IS - 6 N2 - Periodic leg movements during sleep (PLMS) are repetitive jerks of the lower limbs. Their occurrence can be isolated or part of various sleep disorders, such as restless legs syndrome (RLS), narcolepsy and obstructive sleep apnoea. Dopamine agonists are very effective in suppressing PLMS in RLS from the first night of administration. PLMS are often associated with cortical and autonomic arousals and may contribute to sleep disruption. Herein, a case of association between PLMS, Cheyne-Stokes respiration (CSR) and severe insomnia is described. Repeated polysomnographic studies demonstrated a clear synchronisation between PLMS and hyperventilation episodes, and the complete recovery of CSR, sleep quality and PLMS during nocturnal ventilation. In the same patient, pharmacological treatment with a dopamine agonist was ineffective on both PLMS and CSR. These results suggest that periodic leg movements during sleep coupled with central breathing events, similar to those observed in conjunction with obstructive events, may have a different origin in terms of neurotransmitter and pathway implicated, compared with periodic leg movements during sleep in restless legs syndrome, and are resolved by treatment of the respiratory abnormalities. SN - 1399-3003 UR - https://www.unboundmedicine.com/medline/citation/19043012/Periodic_leg_movements_in_Cheyne_Stokes_respiration_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=19043012 DB - PRIME DP - Unbound Medicine ER -