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The CA3 subregion of the hippocampus is critical for episodic memory processing by means of relational encoding in rats.
Behav Neurosci. 2008 Dec; 122(6):1217-25.BN

Abstract

This experiment tested the theory that the CA3 subregion of the hippocampus mediates episodic learning of arbitrary associations. The authors developed 2 tasks based on the episodic flavor-place paired-associate task described by M. Day, R. Langston, and R. G. Morris (2003): an object-cued spatial location recall task and a spatial location-cued object recall task. After rats were trained to a criterion of 80% correct on 1 of the 2 tasks, they received either a dorsal CA3 lesion or a vehicle control lesion. Control animals continued performing well on both tasks. Rats with lesions to dorsal CA3 were impaired on both tasks and performed at chance but were able to perform a nonepisodic version of the task as a control. These data suggest that CA3 mediates episodic learning of arbitrary associations as tested in the 1-trial object-cued spatial location recall and spatial location-cued object recall tasks.

Authors+Show Affiliations

Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA. rpkesner@behscu.utah.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19045941

Citation

Kesner, Raymond P., et al. "The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing By Means of Relational Encoding in Rats." Behavioral Neuroscience, vol. 122, no. 6, 2008, pp. 1217-25.
Kesner RP, Hunsaker MR, Warthen MW. The CA3 subregion of the hippocampus is critical for episodic memory processing by means of relational encoding in rats. Behav Neurosci. 2008;122(6):1217-25.
Kesner, R. P., Hunsaker, M. R., & Warthen, M. W. (2008). The CA3 subregion of the hippocampus is critical for episodic memory processing by means of relational encoding in rats. Behavioral Neuroscience, 122(6), 1217-25. https://doi.org/10.1037/a0013592
Kesner RP, Hunsaker MR, Warthen MW. The CA3 Subregion of the Hippocampus Is Critical for Episodic Memory Processing By Means of Relational Encoding in Rats. Behav Neurosci. 2008;122(6):1217-25. PubMed PMID: 19045941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CA3 subregion of the hippocampus is critical for episodic memory processing by means of relational encoding in rats. AU - Kesner,Raymond P, AU - Hunsaker,Michael R, AU - Warthen,Matthew W, PY - 2008/12/3/pubmed PY - 2009/4/15/medline PY - 2008/12/3/entrez SP - 1217 EP - 25 JF - Behavioral neuroscience JO - Behav Neurosci VL - 122 IS - 6 N2 - This experiment tested the theory that the CA3 subregion of the hippocampus mediates episodic learning of arbitrary associations. The authors developed 2 tasks based on the episodic flavor-place paired-associate task described by M. Day, R. Langston, and R. G. Morris (2003): an object-cued spatial location recall task and a spatial location-cued object recall task. After rats were trained to a criterion of 80% correct on 1 of the 2 tasks, they received either a dorsal CA3 lesion or a vehicle control lesion. Control animals continued performing well on both tasks. Rats with lesions to dorsal CA3 were impaired on both tasks and performed at chance but were able to perform a nonepisodic version of the task as a control. These data suggest that CA3 mediates episodic learning of arbitrary associations as tested in the 1-trial object-cued spatial location recall and spatial location-cued object recall tasks. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/19045941/The_CA3_subregion_of_the_hippocampus_is_critical_for_episodic_memory_processing_by_means_of_relational_encoding_in_rats_ L2 - http://content.apa.org/journals/bne/122/6/1217 DB - PRIME DP - Unbound Medicine ER -