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The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent.
Behav Neurosci. 2008 Dec; 122(6):1378-82.BN

Abstract

Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors' group. Here, the authors report that when administered 10 or 20 microg/1 microl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.

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Authors+Show Affiliations

Murillo-Rodríguez E
Facultad de Medicina, Laboratorio de Neurobiologia, Universidad Autonoma de Campeche, Campeche, Mexico. emurillo@uacam.mx
Millán-Aldaco D
No affiliation info available
Palomero-Rivero M
No affiliation info available
Mechoulam R
No affiliation info available
Drucker-Colín R
No affiliation info available

MeSH

AnimalsBehavior, AnimalCannabidiolCannabisDose-Response Relationship, DrugElectroencephalographyElectromyographyHypothalamic Area, LateralMaleProto-Oncogene Proteins c-fosRandom AllocationRaphe NucleiRatsRats, WistarSleepWakefulness

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19045957

Citation

Murillo-Rodríguez, Eric, et al. "The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-inducing Agent." Behavioral Neuroscience, vol. 122, no. 6, 2008, pp. 1378-82.
Murillo-Rodríguez E, Millán-Aldaco D, Palomero-Rivero M, et al. The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. Behav Neurosci. 2008;122(6):1378-82.
Murillo-Rodríguez, E., Millán-Aldaco, D., Palomero-Rivero, M., Mechoulam, R., & Drucker-Colín, R. (2008). The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. Behavioral Neuroscience, 122(6), 1378-82. https://doi.org/10.1037/a0013278
Murillo-Rodríguez E, et al. The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-inducing Agent. Behav Neurosci. 2008;122(6):1378-82. PubMed PMID: 19045957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. AU - Murillo-Rodríguez,Eric, AU - Millán-Aldaco,Diana, AU - Palomero-Rivero,Marcela, AU - Mechoulam,Raphael, AU - Drucker-Colín,René, PY - 2008/12/3/pubmed PY - 2009/4/15/medline PY - 2008/12/3/entrez SP - 1378 EP - 82 JF - Behavioral neuroscience JO - Behav Neurosci VL - 122 IS - 6 N2 - Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors' group. Here, the authors report that when administered 10 or 20 microg/1 microl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/19045957/The_nonpsychoactive_Cannabis_constituent_cannabidiol_is_a_wake_inducing_agent_ L2 - http://content.apa.org/journals/bne/122/6/1378 DB - PRIME DP - Unbound Medicine ER -