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The NCEP-ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease.
Diabet Med. 2008 Dec; 25(12):1419-25.DM

Abstract

AIM

To examine the association between chronic kidney disease (CKD) and the metabolic syndrome (MetS) using both International Diabetes Federation (IDF) and National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATPIII) definitions in Chinese subjects with Type 2 diabetes.

METHODS

Subjects with Type 2 diabetes were categorized according to the presence or absence of MetS by IDF or NCEP-ATPIII criteria. CKD was considered present if glomerular filtration rate, calculated using the abbreviated equation developed by the Modification of Diet in Renal Disease study with Chinese modification, was < 60 ml/min per 1.73 m2. Multivariate logistic regression analysis of the association between CKD and MetS by either definition was performed.

RESULTS

Of 6350 subjects (mean age 55.1 +/- 13.3 years), 3439 (54.2%) and 3204 (50.5%) had MetS by IDF and NCEP-ATPIII definitions, respectively. Using the IDF definition, the presence of MetS was not associated with CKD [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.71, 1.29, P = 0.784]. In contrast, the association with CKD was significant when MetS was defined by the NCEP-ATPIII definition (OR 1.75, 95% CI 1.37, 2.24, P < 0.001). In subjects who did not have MetS (n = 2911) as defined by IDF criteria, 997 fulfilled the MetS criteria of NCEP-ATP III. The association with CKD was stronger, after adjustment for covariates, in these subjects (OR 1.42, 95% CI 1.03, 1.97, P = 0.032) compared with subjects who met IDF criteria of MetS.

CONCLUSION

In Type 2 diabetes, NCEP-ATPIII, but not the IDF definition of MetS, identifies a subgroup of patients who have a higher risk of CKD.

Authors+Show Affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19046240

Citation

Luk, A O Y., et al. "The NCEP-ATPIII but Not the IDF Criteria for the Metabolic Syndrome Identify Type 2 Diabetic Patients at Increased Risk of Chronic Kidney Disease." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 25, no. 12, 2008, pp. 1419-25.
Luk AO, Ma RC, So WY, et al. The NCEP-ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease. Diabet Med. 2008;25(12):1419-25.
Luk, A. O., Ma, R. C., So, W. Y., Yang, X. L., Kong, A. P., Ozaki, R., Ko, G. T., Chow, C. C., Cockram, C. S., Chan, J. C., & Tong, P. C. (2008). The NCEP-ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease. Diabetic Medicine : a Journal of the British Diabetic Association, 25(12), 1419-25. https://doi.org/10.1111/j.1464-5491.2008.02602.x
Luk AO, et al. The NCEP-ATPIII but Not the IDF Criteria for the Metabolic Syndrome Identify Type 2 Diabetic Patients at Increased Risk of Chronic Kidney Disease. Diabet Med. 2008;25(12):1419-25. PubMed PMID: 19046240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The NCEP-ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease. AU - Luk,A O Y, AU - Ma,R C W, AU - So,W-Y, AU - Yang,X-L, AU - Kong,A P S, AU - Ozaki,R, AU - Ko,G T C, AU - Chow,C-C, AU - Cockram,C S, AU - Chan,J C N, AU - Tong,P C Y, PY - 2008/12/3/pubmed PY - 2009/10/9/medline PY - 2008/12/3/entrez SP - 1419 EP - 25 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 25 IS - 12 N2 - AIM: To examine the association between chronic kidney disease (CKD) and the metabolic syndrome (MetS) using both International Diabetes Federation (IDF) and National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATPIII) definitions in Chinese subjects with Type 2 diabetes. METHODS: Subjects with Type 2 diabetes were categorized according to the presence or absence of MetS by IDF or NCEP-ATPIII criteria. CKD was considered present if glomerular filtration rate, calculated using the abbreviated equation developed by the Modification of Diet in Renal Disease study with Chinese modification, was < 60 ml/min per 1.73 m2. Multivariate logistic regression analysis of the association between CKD and MetS by either definition was performed. RESULTS: Of 6350 subjects (mean age 55.1 +/- 13.3 years), 3439 (54.2%) and 3204 (50.5%) had MetS by IDF and NCEP-ATPIII definitions, respectively. Using the IDF definition, the presence of MetS was not associated with CKD [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.71, 1.29, P = 0.784]. In contrast, the association with CKD was significant when MetS was defined by the NCEP-ATPIII definition (OR 1.75, 95% CI 1.37, 2.24, P < 0.001). In subjects who did not have MetS (n = 2911) as defined by IDF criteria, 997 fulfilled the MetS criteria of NCEP-ATP III. The association with CKD was stronger, after adjustment for covariates, in these subjects (OR 1.42, 95% CI 1.03, 1.97, P = 0.032) compared with subjects who met IDF criteria of MetS. CONCLUSION: In Type 2 diabetes, NCEP-ATPIII, but not the IDF definition of MetS, identifies a subgroup of patients who have a higher risk of CKD. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/19046240/The_NCEP_ATPIII_but_not_the_IDF_criteria_for_the_metabolic_syndrome_identify_Type_2_diabetic_patients_at_increased_risk_of_chronic_kidney_disease_ L2 - https://doi.org/10.1111/j.1464-5491.2008.02602.x DB - PRIME DP - Unbound Medicine ER -