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NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment.
J Neurochem. 2009 Jan; 108(2):408-16.JN

Abstract

In this study, we investigate the effects of chronic administration of (-)nicotine on the function of the NMDA-mediated modulation of [(3)H]dopamine (DA) release in rat prefrontal cortex (PFC) and nucleus accumbens (NAc). In the PFC synaptosomes NMDA in a concentration-dependent manner evoked [(3)H]DA release in rats chronically treated with vehicle (14 days) with an EC(50) of 13.1 +/- 2.0 microM. The NMDA-evoked overflow of the [(3)H]DA in PFC nerve endings of rats treated with (-)nicotine was significantly lower (-43%) than in vehicle treated rats. The EC(50) was 9.0 +/- 1.4 microM. Exposure of NAc synaptosomes of rats treated with vehicle to NMDA produced an increase in [(3)H]DA overflow with an EC(50) of 14.5 +/- 5.5 microM. This effect was significantly enhanced in chronically treated animals. The EC(50) was 10.5 +/- 0.5 microM. The K(+)-evoked release of [(3)H]DA was not modified by the (-)nicotine administration. Both the changes of the NMDA-evoked [(3)H]DA overflow in the NAc and PFC disappeared after 14 days withdrawal. The results show that chronic (-)nicotine differentially affects the NMDA-mediated [(3)H]DA release in the PFC and NAc of the rat.

Authors+Show Affiliations

Department of Experimental Medicine, Section of Pharmacology and Toxicology, University of Genoa, Genoa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19046354

Citation

Grilli, Massimo, et al. "NMDA-mediated Modulation of Dopamine Release Is Modified in Rat Prefrontal Cortex and Nucleus Accumbens After Chronic Nicotine Treatment." Journal of Neurochemistry, vol. 108, no. 2, 2009, pp. 408-16.
Grilli M, Pittaluga A, Merlo-Pich E, et al. NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. J Neurochem. 2009;108(2):408-16.
Grilli, M., Pittaluga, A., Merlo-Pich, E., & Marchi, M. (2009). NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. Journal of Neurochemistry, 108(2), 408-16. https://doi.org/10.1111/j.1471-4159.2008.05792.x
Grilli M, et al. NMDA-mediated Modulation of Dopamine Release Is Modified in Rat Prefrontal Cortex and Nucleus Accumbens After Chronic Nicotine Treatment. J Neurochem. 2009;108(2):408-16. PubMed PMID: 19046354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment. AU - Grilli,Massimo, AU - Pittaluga,Anna, AU - Merlo-Pich,Emilio, AU - Marchi,Mario, Y1 - 2008/11/19/ PY - 2008/12/3/pubmed PY - 2009/4/9/medline PY - 2008/12/3/entrez SP - 408 EP - 16 JF - Journal of neurochemistry JO - J Neurochem VL - 108 IS - 2 N2 - In this study, we investigate the effects of chronic administration of (-)nicotine on the function of the NMDA-mediated modulation of [(3)H]dopamine (DA) release in rat prefrontal cortex (PFC) and nucleus accumbens (NAc). In the PFC synaptosomes NMDA in a concentration-dependent manner evoked [(3)H]DA release in rats chronically treated with vehicle (14 days) with an EC(50) of 13.1 +/- 2.0 microM. The NMDA-evoked overflow of the [(3)H]DA in PFC nerve endings of rats treated with (-)nicotine was significantly lower (-43%) than in vehicle treated rats. The EC(50) was 9.0 +/- 1.4 microM. Exposure of NAc synaptosomes of rats treated with vehicle to NMDA produced an increase in [(3)H]DA overflow with an EC(50) of 14.5 +/- 5.5 microM. This effect was significantly enhanced in chronically treated animals. The EC(50) was 10.5 +/- 0.5 microM. The K(+)-evoked release of [(3)H]DA was not modified by the (-)nicotine administration. Both the changes of the NMDA-evoked [(3)H]DA overflow in the NAc and PFC disappeared after 14 days withdrawal. The results show that chronic (-)nicotine differentially affects the NMDA-mediated [(3)H]DA release in the PFC and NAc of the rat. SN - 1471-4159 UR - https://www.unboundmedicine.com/medline/citation/19046354/NMDA_mediated_modulation_of_dopamine_release_is_modified_in_rat_prefrontal_cortex_and_nucleus_accumbens_after_chronic_nicotine_treatment_ L2 - https://doi.org/10.1111/j.1471-4159.2008.05792.x DB - PRIME DP - Unbound Medicine ER -