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[Tissue engineering for the repair of cartilage defects].
Rev Chir Orthop Reparatrice Appar Mot. 2008 Dec; 94(8 Suppl):383-93.RC

Abstract

The treatment of full thickness articular defects remains a challenging problem for the orthopaedic surgeon. Beside bone marrow stimulation techniques (microfractures) and autologous osteochondral mosaicplasty, a variety of procedures have been proposed to promote the healing of articular lesions by cultured competent cells. Tissue engineering is an emerging field, whose goal is to repair or replace tissues and organs by delivering the appropriate cells, biomaterials and signaling factors to diseased or damaged areas. In this article, we review the preclinical and clinical literature reported on the fabrication of implantable cartilage structures from chondrocytes and mesenchymal stem cells and discuss potential areas of development in the field of cartilage repair. Before routine use of engineered cartilage grafts in the clinic, the safety and efficacy of these therapies need to be validated in prospective human clinical trials.

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Publisher Full Text
linkinghub.elsevier.com
em-consulte.com

Authors+Show Affiliations

Hannouche D
Service de chirurgie orthopédique, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France. didier.hannouche@lrb.aphp.fr

MeSH

Cartilage, ArticularChondrocytesHumansMesenchymal Stem Cell TransplantationTissue EngineeringTreatment OutcomeWound Healing

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

19046697

Citation

Hannouche, D. "[Tissue Engineering for the Repair of Cartilage Defects]." Revue De Chirurgie Orthopedique Et Reparatrice De L'appareil Moteur, vol. 94, no. 8 Suppl, 2008, pp. 383-93.
Hannouche D. [Tissue engineering for the repair of cartilage defects]. Rev Chir Orthop Reparatrice Appar Mot. 2008;94(8 Suppl):383-93.
Hannouche, D. (2008). [Tissue engineering for the repair of cartilage defects]. Revue De Chirurgie Orthopedique Et Reparatrice De L'appareil Moteur, 94(8 Suppl), 383-93. https://doi.org/10.1016/j.rco.2008.09.004
Hannouche D. [Tissue Engineering for the Repair of Cartilage Defects]. Rev Chir Orthop Reparatrice Appar Mot. 2008;94(8 Suppl):383-93. PubMed PMID: 19046697.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Tissue engineering for the repair of cartilage defects]. A1 - Hannouche,D, Y1 - 2008/11/13/ PY - 2008/12/17/pubmed PY - 2009/11/17/medline PY - 2008/12/17/entrez SP - 383 EP - 93 JF - Revue de chirurgie orthopedique et reparatrice de l'appareil moteur JO - Rev Chir Orthop Reparatrice Appar Mot VL - 94 IS - 8 Suppl N2 - The treatment of full thickness articular defects remains a challenging problem for the orthopaedic surgeon. Beside bone marrow stimulation techniques (microfractures) and autologous osteochondral mosaicplasty, a variety of procedures have been proposed to promote the healing of articular lesions by cultured competent cells. Tissue engineering is an emerging field, whose goal is to repair or replace tissues and organs by delivering the appropriate cells, biomaterials and signaling factors to diseased or damaged areas. In this article, we review the preclinical and clinical literature reported on the fabrication of implantable cartilage structures from chondrocytes and mesenchymal stem cells and discuss potential areas of development in the field of cartilage repair. Before routine use of engineered cartilage grafts in the clinic, the safety and efficacy of these therapies need to be validated in prospective human clinical trials. SN - 1776-2553 UR - https://www.unboundmedicine.com/medline/citation/19046697/[Tissue_engineering_for_the_repair_of_cartilage_defects]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-1040(08)00598-9 DB - PRIME DP - Unbound Medicine ER -