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Relation between hemostatic parameters and prognostic/predictive factors in breast cancer.
Eur J Intern Med. 2008 Dec; 19(8):602-7.EJ

Abstract

BACKGROUND

In our study, we searched for a relation between various prognostic and predictive factors and hemostatic parameters.

METHODS

One hundred women with newly diagnosed breast cancer after surgery were included. Patients did not receive systemic therapy or radiotherapy. The control group included 100 healthy, age-matched women. In the patient group, age, menopausal status, tumor size, grade, axillary lymph node status, steroid receptor status, p53, and HER2/neu were evaluated. Plasma levels of factor VIII, factor IX, D-dimer, fibrinogen, protein C, protein S, vWF, and antithrombin III were measured in both groups.

RESULTS

Plasma levels of factor VIII, factor IX, vWF, and CRP in patients with breast cancer were higher than those in controls. Protein S levels in patients were lower than in controls. There was no significant difference in other hemostatic parameters between the groups. In patients with axillary lymph node metastasis, factor VIII levels were significantly higher than in node-negative patients. There was a strong correlation between axillary lymph node status, number of metastatic nodes, and factor VIII levels. There was no correlation between factor VIII levels and CRP. Factor VIII levels were higher in the group having high HER2/neu (3+) than in the group with negativity for HER2/neu.

CONCLUSION

There was a strong correlation between axillary lymph node involvement, number of metastatic nodules, overexpression of HER2/neu, hemostatic parameters, and factor VIII levels. Our study showed that factor VIII level measurement can provide additional data for evaluation of breast cancer patients' prognosis.

Authors+Show Affiliations

Department of Internal Medicine, Ondokuz Mayis University Medical School, Kurupelit/Samsun, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19046726

Citation

Yigit, Engin, et al. "Relation Between Hemostatic Parameters and Prognostic/predictive Factors in Breast Cancer." European Journal of Internal Medicine, vol. 19, no. 8, 2008, pp. 602-7.
Yigit E, Gönüllü G, Yücel I, et al. Relation between hemostatic parameters and prognostic/predictive factors in breast cancer. Eur J Intern Med. 2008;19(8):602-7.
Yigit, E., Gönüllü, G., Yücel, I., Turgut, M., Erdem, D., & Cakar, B. (2008). Relation between hemostatic parameters and prognostic/predictive factors in breast cancer. European Journal of Internal Medicine, 19(8), 602-7. https://doi.org/10.1016/j.ejim.2007.06.036
Yigit E, et al. Relation Between Hemostatic Parameters and Prognostic/predictive Factors in Breast Cancer. Eur J Intern Med. 2008;19(8):602-7. PubMed PMID: 19046726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between hemostatic parameters and prognostic/predictive factors in breast cancer. AU - Yigit,Engin, AU - Gönüllü,Güzin, AU - Yücel,Idris, AU - Turgut,Mehmet, AU - Erdem,Dilek, AU - Cakar,Burcu, Y1 - 2008/04/16/ PY - 2007/04/12/received PY - 2007/05/25/revised PY - 2007/06/06/accepted PY - 2008/12/3/pubmed PY - 2009/4/3/medline PY - 2008/12/3/entrez SP - 602 EP - 7 JF - European journal of internal medicine JO - Eur J Intern Med VL - 19 IS - 8 N2 - BACKGROUND: In our study, we searched for a relation between various prognostic and predictive factors and hemostatic parameters. METHODS: One hundred women with newly diagnosed breast cancer after surgery were included. Patients did not receive systemic therapy or radiotherapy. The control group included 100 healthy, age-matched women. In the patient group, age, menopausal status, tumor size, grade, axillary lymph node status, steroid receptor status, p53, and HER2/neu were evaluated. Plasma levels of factor VIII, factor IX, D-dimer, fibrinogen, protein C, protein S, vWF, and antithrombin III were measured in both groups. RESULTS: Plasma levels of factor VIII, factor IX, vWF, and CRP in patients with breast cancer were higher than those in controls. Protein S levels in patients were lower than in controls. There was no significant difference in other hemostatic parameters between the groups. In patients with axillary lymph node metastasis, factor VIII levels were significantly higher than in node-negative patients. There was a strong correlation between axillary lymph node status, number of metastatic nodes, and factor VIII levels. There was no correlation between factor VIII levels and CRP. Factor VIII levels were higher in the group having high HER2/neu (3+) than in the group with negativity for HER2/neu. CONCLUSION: There was a strong correlation between axillary lymph node involvement, number of metastatic nodules, overexpression of HER2/neu, hemostatic parameters, and factor VIII levels. Our study showed that factor VIII level measurement can provide additional data for evaluation of breast cancer patients' prognosis. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/19046726/Relation_between_hemostatic_parameters_and_prognostic/predictive_factors_in_breast_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(08)00078-2 DB - PRIME DP - Unbound Medicine ER -