Tags

Type your tag names separated by a space and hit enter

Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy.
Int J Radiat Oncol Biol Phys. 2009 May 01; 74(1):15-20.IJ

Abstract

PURPOSE

To evaluate the efficacy of carbon ion radiotherapy for mucosal malignant melanoma of the head and neck.

METHODS AND MATERIALS

Between 1994 and 2004, 72 patients with mucosal malignant melanoma of the head and neck were treated with carbon ion beams in three prospective studies. Total dose ranged from 52.8 GyE to 64 GyE given in 16 fixed fractions over 4 weeks. Clinical parameters including gender, age, Karnofsky index, tumor site, tumor volume, tumor status, total dose, fraction size, and treatment time were evaluated in relation to local control and overall survival.

RESULTS

The median follow-up period was 49.2 months (range, 16.8-108.5 months). Treatment toxicity was within acceptable limits, and no patients showed Grade 3 or higher toxicity in the late phase. The 5-year local control rate was 84.1%. In relation to local control, there were no significant differences in any parameters evaluated. The 5-year overall and cause-specific survival rates were 27.0% and 39.6%, respectively. For overall survival, however, tumor volume (>/=100 mL) was found to be the most significant prognostic parameter. Of the patients who developed distant metastasis, 85% were free from local recurrence.

CONCLUSION

Carbon ion radiotherapy is a safe and effective treatment for mucosal malignant melanoma of the head and neck in terms of high local control and acceptable toxicities. Overall survival rate was better than in those treated with conventional radiotherapy and was comparable to that with surgery.

Authors+Show Affiliations

National Institute of Radiological Sciences, Research Center Hospital for Charged Particle Therapy, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase I
Clinical Trial, Phase II
Journal Article

Language

eng

PubMed ID

19046826

Citation

Yanagi, Takeshi, et al. "Mucosal Malignant Melanoma of the Head and Neck Treated By Carbon Ion Radiotherapy." International Journal of Radiation Oncology, Biology, Physics, vol. 74, no. 1, 2009, pp. 15-20.
Yanagi T, Mizoe JE, Hasegawa A, et al. Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy. Int J Radiat Oncol Biol Phys. 2009;74(1):15-20.
Yanagi, T., Mizoe, J. E., Hasegawa, A., Takagi, R., Bessho, H., Onda, T., Kamada, T., Okamoto, Y., & Tsujii, H. (2009). Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 74(1), 15-20. https://doi.org/10.1016/j.ijrobp.2008.07.056
Yanagi T, et al. Mucosal Malignant Melanoma of the Head and Neck Treated By Carbon Ion Radiotherapy. Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):15-20. PubMed PMID: 19046826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy. AU - Yanagi,Takeshi, AU - Mizoe,Jun-Etsu, AU - Hasegawa,Azusa, AU - Takagi,Ryo, AU - Bessho,Hiroki, AU - Onda,Takeshi, AU - Kamada,Tadashi, AU - Okamoto,Yoshitaka, AU - Tsujii,Hirohiko, Y1 - 2008/11/27/ PY - 2008/03/31/received PY - 2008/07/10/revised PY - 2008/07/24/accepted PY - 2008/12/3/pubmed PY - 2009/4/22/medline PY - 2008/12/3/entrez SP - 15 EP - 20 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 74 IS - 1 N2 - PURPOSE: To evaluate the efficacy of carbon ion radiotherapy for mucosal malignant melanoma of the head and neck. METHODS AND MATERIALS: Between 1994 and 2004, 72 patients with mucosal malignant melanoma of the head and neck were treated with carbon ion beams in three prospective studies. Total dose ranged from 52.8 GyE to 64 GyE given in 16 fixed fractions over 4 weeks. Clinical parameters including gender, age, Karnofsky index, tumor site, tumor volume, tumor status, total dose, fraction size, and treatment time were evaluated in relation to local control and overall survival. RESULTS: The median follow-up period was 49.2 months (range, 16.8-108.5 months). Treatment toxicity was within acceptable limits, and no patients showed Grade 3 or higher toxicity in the late phase. The 5-year local control rate was 84.1%. In relation to local control, there were no significant differences in any parameters evaluated. The 5-year overall and cause-specific survival rates were 27.0% and 39.6%, respectively. For overall survival, however, tumor volume (>/=100 mL) was found to be the most significant prognostic parameter. Of the patients who developed distant metastasis, 85% were free from local recurrence. CONCLUSION: Carbon ion radiotherapy is a safe and effective treatment for mucosal malignant melanoma of the head and neck in terms of high local control and acceptable toxicities. Overall survival rate was better than in those treated with conventional radiotherapy and was comparable to that with surgery. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/19046826/Mucosal_malignant_melanoma_of_the_head_and_neck_treated_by_carbon_ion_radiotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(08)03314-2 DB - PRIME DP - Unbound Medicine ER -