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A "silent" course of normotensive scleroderma renal crisis: case report and review of the literature.
Rheumatol Int. 2009 Aug; 29(10):1223-9.RI

Abstract

Scleroderma renal crisis (SRC) is a complication of systemic sclerosis characterized by the sudden onset of accelerated arterial hypertension, followed by progressive renal failure. Rarely, patients with SRC may be normotensive on presentation. These patients have poorer prognosis and higher mortality rates than those with hypertensive SRC. This is partly explained by the insidious course of normotensive SRC leading to delayed diagnosis and treatment. Normotensive patients also seem to be less responsive to current treatment modalities. Since available data on etiology, pathogenesis, and risk factors of the disease are inadequate, no effective therapy has been established to date. We report a patient with diffuse cutaneous scleroderma who developed SRC during his hospitalization. The patient remained normotensive and had an insidious course until oliguria and signs of hypervolemia occurred. Etiology, pathogenesis, risk factors, diagnosis, treatment modalities and prognosis of normotensive SRC are also discussed through previously published reports.

Authors+Show Affiliations

Department of Nephrology, Ankara Numune Research and Education Hospital, Ankara Numune Eğitim ve Araştirma Hastanesi Nefroloji Kliniği, Samanpazari, 06100, Ankara, Turkey. drakomd@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

19048256

Citation

Akoglu, Hadim, et al. "A "silent" Course of Normotensive Scleroderma Renal Crisis: Case Report and Review of the Literature." Rheumatology International, vol. 29, no. 10, 2009, pp. 1223-9.
Akoglu H, Atilgan GK, Ozturk R, et al. A "silent" course of normotensive scleroderma renal crisis: case report and review of the literature. Rheumatol Int. 2009;29(10):1223-9.
Akoglu, H., Atilgan, G. K., Ozturk, R., Yenigun, E. C., Gonul, I. I., & Odabas, A. R. (2009). A "silent" course of normotensive scleroderma renal crisis: case report and review of the literature. Rheumatology International, 29(10), 1223-9. https://doi.org/10.1007/s00296-008-0807-1
Akoglu H, et al. A "silent" Course of Normotensive Scleroderma Renal Crisis: Case Report and Review of the Literature. Rheumatol Int. 2009;29(10):1223-9. PubMed PMID: 19048256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A "silent" course of normotensive scleroderma renal crisis: case report and review of the literature. AU - Akoglu,Hadim, AU - Atilgan,Gokhan Kadir, AU - Ozturk,Ramazan, AU - Yenigun,Ezgi Coskun, AU - Gonul,Ipek Isik, AU - Odabas,Ali Riza, Y1 - 2008/12/02/ PY - 2008/08/09/received PY - 2008/11/20/accepted PY - 2008/12/3/pubmed PY - 2009/11/5/medline PY - 2008/12/3/entrez SP - 1223 EP - 9 JF - Rheumatology international JO - Rheumatol. Int. VL - 29 IS - 10 N2 - Scleroderma renal crisis (SRC) is a complication of systemic sclerosis characterized by the sudden onset of accelerated arterial hypertension, followed by progressive renal failure. Rarely, patients with SRC may be normotensive on presentation. These patients have poorer prognosis and higher mortality rates than those with hypertensive SRC. This is partly explained by the insidious course of normotensive SRC leading to delayed diagnosis and treatment. Normotensive patients also seem to be less responsive to current treatment modalities. Since available data on etiology, pathogenesis, and risk factors of the disease are inadequate, no effective therapy has been established to date. We report a patient with diffuse cutaneous scleroderma who developed SRC during his hospitalization. The patient remained normotensive and had an insidious course until oliguria and signs of hypervolemia occurred. Etiology, pathogenesis, risk factors, diagnosis, treatment modalities and prognosis of normotensive SRC are also discussed through previously published reports. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/19048256/A_"silent"_course_of_normotensive_scleroderma_renal_crisis:_case_report_and_review_of_the_literature_ L2 - https://dx.doi.org/10.1007/s00296-008-0807-1 DB - PRIME DP - Unbound Medicine ER -