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Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura.
J Am Assoc Lab Anim Sci. 2008 Nov; 47(6):51-5.JA

Abstract

Trichuris trichiura is a common intestinal nematode parasite of captive baboons. We evaluated the efficacy of fenbendazole formulated in a commercial primate diet (FBZ-PD) for treating specific pathogen-free (SPF) baboons (Papio cynocephalus anubis) naturally infected with Trichuris trichiura. Twenty-nine baboons, housed indoors in 3 separate rooms, were fed FBZ-PD for 5 d, whereas 4 baboons housed in another isolated area served as untreated controls. The efficacy of FBZ-PD was measured as reduction in the number of T. trichiura eggs in host feces after treatment as determined by quantitative fecal flotation examination. All baboons that received FBZ-PD stopped shedding T. trichiura eggs by 7 d after initiation of treatment, and remained negative until at least 119 d after treatment. However, eggs of T. trichiura were present in the feces of 3 (10.3%) experimental baboons at 154 d after treatment. Untreated control baboons shed T. trichiura eggs throughout the entire study. Our results indicate that FBZ-PD was efficacious for treating SPF baboons infected with T. trichiura.

Links

Publisher Full Text
ncbi.nlm.nih.gov
ingentaconnect.com
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Authors+Show Affiliations

Reichard MV
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. mason.reichard@okstate.edu
Wolf RF
No affiliation info available
Clingenpeel LC
No affiliation info available
Doan SK
No affiliation info available
Jones AN
No affiliation info available
Gray KM
No affiliation info available

MeSH

AnimalsAntinematodal AgentsDietFecesFenbendazolePapio cynocephalusParasite Egg CountSpecific Pathogen-Free OrganismsTrichuriasisTrichuris

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19049254

Citation

Reichard, Mason V., et al. "Efficacy of Fenbendazole Formulated in a Commercial Primate Diet for Treating Specific Pathogen-free Baboons (Papio Cynocephalus Anubis) Infected With Trichuris Trichiura." Journal of the American Association for Laboratory Animal Science : JAALAS, vol. 47, no. 6, 2008, pp. 51-5.
Reichard MV, Wolf RF, Clingenpeel LC, et al. Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. J Am Assoc Lab Anim Sci. 2008;47(6):51-5.
Reichard, M. V., Wolf, R. F., Clingenpeel, L. C., Doan, S. K., Jones, A. N., & Gray, K. M. (2008). Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. Journal of the American Association for Laboratory Animal Science : JAALAS, 47(6), 51-5.
Reichard MV, et al. Efficacy of Fenbendazole Formulated in a Commercial Primate Diet for Treating Specific Pathogen-free Baboons (Papio Cynocephalus Anubis) Infected With Trichuris Trichiura. J Am Assoc Lab Anim Sci. 2008;47(6):51-5. PubMed PMID: 19049254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. AU - Reichard,Mason V, AU - Wolf,Roman F, AU - Clingenpeel,Lindsay C, AU - Doan,Sandra K, AU - Jones,Amy N, AU - Gray,Kristene M, PY - 2008/12/4/pubmed PY - 2009/1/22/medline PY - 2008/12/4/entrez SP - 51 EP - 5 JF - Journal of the American Association for Laboratory Animal Science : JAALAS JO - J Am Assoc Lab Anim Sci VL - 47 IS - 6 N2 - Trichuris trichiura is a common intestinal nematode parasite of captive baboons. We evaluated the efficacy of fenbendazole formulated in a commercial primate diet (FBZ-PD) for treating specific pathogen-free (SPF) baboons (Papio cynocephalus anubis) naturally infected with Trichuris trichiura. Twenty-nine baboons, housed indoors in 3 separate rooms, were fed FBZ-PD for 5 d, whereas 4 baboons housed in another isolated area served as untreated controls. The efficacy of FBZ-PD was measured as reduction in the number of T. trichiura eggs in host feces after treatment as determined by quantitative fecal flotation examination. All baboons that received FBZ-PD stopped shedding T. trichiura eggs by 7 d after initiation of treatment, and remained negative until at least 119 d after treatment. However, eggs of T. trichiura were present in the feces of 3 (10.3%) experimental baboons at 154 d after treatment. Untreated control baboons shed T. trichiura eggs throughout the entire study. Our results indicate that FBZ-PD was efficacious for treating SPF baboons infected with T. trichiura. SN - 1559-6109 UR - https://www.unboundmedicine.com/medline/citation/19049254/Efficacy_of_fenbendazole_formulated_in_a_commercial_primate_diet_for_treating_specific_pathogen_free_baboons__Papio_cynocephalus_anubis__infected_with_Trichuris_trichiura_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1559-6109&volume=47&issue=6&spage=51&aulast=Reichard DB - PRIME DP - Unbound Medicine ER -