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Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura.
J Am Assoc Lab Anim Sci. 2008 Nov; 47(6):51-5.JA

Abstract

Trichuris trichiura is a common intestinal nematode parasite of captive baboons. We evaluated the efficacy of fenbendazole formulated in a commercial primate diet (FBZ-PD) for treating specific pathogen-free (SPF) baboons (Papio cynocephalus anubis) naturally infected with Trichuris trichiura. Twenty-nine baboons, housed indoors in 3 separate rooms, were fed FBZ-PD for 5 d, whereas 4 baboons housed in another isolated area served as untreated controls. The efficacy of FBZ-PD was measured as reduction in the number of T. trichiura eggs in host feces after treatment as determined by quantitative fecal flotation examination. All baboons that received FBZ-PD stopped shedding T. trichiura eggs by 7 d after initiation of treatment, and remained negative until at least 119 d after treatment. However, eggs of T. trichiura were present in the feces of 3 (10.3%) experimental baboons at 154 d after treatment. Untreated control baboons shed T. trichiura eggs throughout the entire study. Our results indicate that FBZ-PD was efficacious for treating SPF baboons infected with T. trichiura.

Authors+Show Affiliations

Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. mason.reichard@okstate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19049254

Citation

Reichard, Mason V., et al. "Efficacy of Fenbendazole Formulated in a Commercial Primate Diet for Treating Specific Pathogen-free Baboons (Papio Cynocephalus Anubis) Infected With Trichuris Trichiura." Journal of the American Association for Laboratory Animal Science : JAALAS, vol. 47, no. 6, 2008, pp. 51-5.
Reichard MV, Wolf RF, Clingenpeel LC, et al. Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. J Am Assoc Lab Anim Sci. 2008;47(6):51-5.
Reichard, M. V., Wolf, R. F., Clingenpeel, L. C., Doan, S. K., Jones, A. N., & Gray, K. M. (2008). Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. Journal of the American Association for Laboratory Animal Science : JAALAS, 47(6), 51-5.
Reichard MV, et al. Efficacy of Fenbendazole Formulated in a Commercial Primate Diet for Treating Specific Pathogen-free Baboons (Papio Cynocephalus Anubis) Infected With Trichuris Trichiura. J Am Assoc Lab Anim Sci. 2008;47(6):51-5. PubMed PMID: 19049254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of fenbendazole formulated in a commercial primate diet for treating specific pathogen-free baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. AU - Reichard,Mason V, AU - Wolf,Roman F, AU - Clingenpeel,Lindsay C, AU - Doan,Sandra K, AU - Jones,Amy N, AU - Gray,Kristene M, PY - 2008/12/4/pubmed PY - 2009/1/22/medline PY - 2008/12/4/entrez SP - 51 EP - 5 JF - Journal of the American Association for Laboratory Animal Science : JAALAS JO - J Am Assoc Lab Anim Sci VL - 47 IS - 6 N2 - Trichuris trichiura is a common intestinal nematode parasite of captive baboons. We evaluated the efficacy of fenbendazole formulated in a commercial primate diet (FBZ-PD) for treating specific pathogen-free (SPF) baboons (Papio cynocephalus anubis) naturally infected with Trichuris trichiura. Twenty-nine baboons, housed indoors in 3 separate rooms, were fed FBZ-PD for 5 d, whereas 4 baboons housed in another isolated area served as untreated controls. The efficacy of FBZ-PD was measured as reduction in the number of T. trichiura eggs in host feces after treatment as determined by quantitative fecal flotation examination. All baboons that received FBZ-PD stopped shedding T. trichiura eggs by 7 d after initiation of treatment, and remained negative until at least 119 d after treatment. However, eggs of T. trichiura were present in the feces of 3 (10.3%) experimental baboons at 154 d after treatment. Untreated control baboons shed T. trichiura eggs throughout the entire study. Our results indicate that FBZ-PD was efficacious for treating SPF baboons infected with T. trichiura. SN - 1559-6109 UR - https://www.unboundmedicine.com/medline/citation/19049254/Efficacy_of_fenbendazole_formulated_in_a_commercial_primate_diet_for_treating_specific_pathogen_free_baboons__Papio_cynocephalus_anubis__infected_with_Trichuris_trichiura_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1559-6109&volume=47&issue=6&spage=51&aulast=Reichard DB - PRIME DP - Unbound Medicine ER -