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Membranoproliferative glomerulonephritis and light-chain nephropathy in association with chronic lymphocytic leukemia.
Clin Nephrol. 2008 Dec; 70(6):527-31.CN

Abstract

The incidence of nephrotic syndrome co-existing with chronic lymphocytic leukemia (CLL) is a rare condition. Almost any glomerular pathology may accompany CLL. The most frequent of all is membranoproliferative glomerulonephritis (MPGN). Moreover, in 5 - 10% of patients with CLL, monoclonal gammopathy may be detected in serum and/or urine samples. There are no well-established treatment protocols for those CLL patients with accompanying nephrotic syndrome. In this case report, we present a 55-year-old female patient diagnosed with CLL, developing nephrotic syndrome, renal dysfunction and IgG k-type monoclonal gammopathy in the follow-up. The renal biopsy revealed glomerular and tubular deposits of k-chain and histopathology of membranoproliferative glomerulonephritis. Rituximab along with CVP (cyclophosphamide - vincristine - prednisolone) chemotherapy regimen was initiated. At the end of 6 courses of treatment, the patient was on "nephrologic" partial remission as the serum creatinine and albumin levels had returned to normal and proteinuria decreased by more than 50%. The patient was also in partial remission for CLL. In conclusion, in patients with CLL and nephrotic syndrome, presence of MPGN along with light-chain nephropathy is rarely reported. Several different treatment protocols are discussed for these patients. Among these regimes, R-CVP is an acceptable alternative for CLL patients with MPGN.

Authors+Show Affiliations

Department of Nephrology, Faculty of Medicine, Gazi University, Besevler Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19049712

Citation

Mutluay, R, et al. "Membranoproliferative Glomerulonephritis and Light-chain Nephropathy in Association With Chronic Lymphocytic Leukemia." Clinical Nephrology, vol. 70, no. 6, 2008, pp. 527-31.
Mutluay R, Aki SZ, Erten Y, et al. Membranoproliferative glomerulonephritis and light-chain nephropathy in association with chronic lymphocytic leukemia. Clin Nephrol. 2008;70(6):527-31.
Mutluay, R., Aki, S. Z., Erten, Y., Konca, C., Yagci, M., Barit, G., & Sindel, S. (2008). Membranoproliferative glomerulonephritis and light-chain nephropathy in association with chronic lymphocytic leukemia. Clinical Nephrology, 70(6), 527-31.
Mutluay R, et al. Membranoproliferative Glomerulonephritis and Light-chain Nephropathy in Association With Chronic Lymphocytic Leukemia. Clin Nephrol. 2008;70(6):527-31. PubMed PMID: 19049712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Membranoproliferative glomerulonephritis and light-chain nephropathy in association with chronic lymphocytic leukemia. AU - Mutluay,R, AU - Aki,S Zeynep, AU - Erten,Y, AU - Konca,C, AU - Yagci,M, AU - Barit,G, AU - Sindel,S, PY - 2008/12/4/pubmed PY - 2009/3/25/medline PY - 2008/12/4/entrez SP - 527 EP - 31 JF - Clinical nephrology JO - Clin. Nephrol. VL - 70 IS - 6 N2 - The incidence of nephrotic syndrome co-existing with chronic lymphocytic leukemia (CLL) is a rare condition. Almost any glomerular pathology may accompany CLL. The most frequent of all is membranoproliferative glomerulonephritis (MPGN). Moreover, in 5 - 10% of patients with CLL, monoclonal gammopathy may be detected in serum and/or urine samples. There are no well-established treatment protocols for those CLL patients with accompanying nephrotic syndrome. In this case report, we present a 55-year-old female patient diagnosed with CLL, developing nephrotic syndrome, renal dysfunction and IgG k-type monoclonal gammopathy in the follow-up. The renal biopsy revealed glomerular and tubular deposits of k-chain and histopathology of membranoproliferative glomerulonephritis. Rituximab along with CVP (cyclophosphamide - vincristine - prednisolone) chemotherapy regimen was initiated. At the end of 6 courses of treatment, the patient was on "nephrologic" partial remission as the serum creatinine and albumin levels had returned to normal and proteinuria decreased by more than 50%. The patient was also in partial remission for CLL. In conclusion, in patients with CLL and nephrotic syndrome, presence of MPGN along with light-chain nephropathy is rarely reported. Several different treatment protocols are discussed for these patients. Among these regimes, R-CVP is an acceptable alternative for CLL patients with MPGN. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/19049712/Membranoproliferative_glomerulonephritis_and_light_chain_nephropathy_in_association_with_chronic_lymphocytic_leukemia_ L2 - http://www.diseaseinfosearch.org/result/3081 DB - PRIME DP - Unbound Medicine ER -