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Biochemical and functional properties of the store-operated Ca2+ channels.
Cell Signal. 2009 Apr; 21(4):457-61.CS

Abstract

Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) entry in excitable and non-excitable cells. The best-characterised store-operated current is I(CRAC), but other currents activated by Ca(2+) store depletion have also been reported. The recent identification of the proteins stromal interaction molecule 1 (STIM1) and Orai1 has shed new light on the nature and regulation of SOC channels. STIM1 has been presented as the endoplasmic reticulum (ER) Ca(2+) sensor that communicates the content of the Ca(2+) stores to the store-operated channels, a mechanism that involves redistribution of STIM1 to peripheral ER sites and co-clustering with the Ca(2+) channel subunit, Orai1. Interestingly, TRPC1, which has long been proposed as a SOC channel candidate, associates with Orai1 and STIM1 in a ternary complex that appears to increase the variability of SOC currents available to modulate cell function.

Authors+Show Affiliations

Department of Physiology (Cell Physiology Research Group), University of Extremadura, Cáceres 10071, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19049864

Citation

Salido, Ginés M., et al. "Biochemical and Functional Properties of the Store-operated Ca2+ Channels." Cellular Signalling, vol. 21, no. 4, 2009, pp. 457-61.
Salido GM, Sage SO, Rosado JA. Biochemical and functional properties of the store-operated Ca2+ channels. Cell Signal. 2009;21(4):457-61.
Salido, G. M., Sage, S. O., & Rosado, J. A. (2009). Biochemical and functional properties of the store-operated Ca2+ channels. Cellular Signalling, 21(4), 457-61. https://doi.org/10.1016/j.cellsig.2008.11.005
Salido GM, Sage SO, Rosado JA. Biochemical and Functional Properties of the Store-operated Ca2+ Channels. Cell Signal. 2009;21(4):457-61. PubMed PMID: 19049864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical and functional properties of the store-operated Ca2+ channels. AU - Salido,Ginés M, AU - Sage,Stewart O, AU - Rosado,Juan A, Y1 - 2008/11/13/ PY - 2008/10/07/received PY - 2008/11/10/accepted PY - 2008/12/4/pubmed PY - 2009/6/23/medline PY - 2008/12/4/entrez SP - 457 EP - 61 JF - Cellular signalling JO - Cell Signal VL - 21 IS - 4 N2 - Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) entry in excitable and non-excitable cells. The best-characterised store-operated current is I(CRAC), but other currents activated by Ca(2+) store depletion have also been reported. The recent identification of the proteins stromal interaction molecule 1 (STIM1) and Orai1 has shed new light on the nature and regulation of SOC channels. STIM1 has been presented as the endoplasmic reticulum (ER) Ca(2+) sensor that communicates the content of the Ca(2+) stores to the store-operated channels, a mechanism that involves redistribution of STIM1 to peripheral ER sites and co-clustering with the Ca(2+) channel subunit, Orai1. Interestingly, TRPC1, which has long been proposed as a SOC channel candidate, associates with Orai1 and STIM1 in a ternary complex that appears to increase the variability of SOC currents available to modulate cell function. SN - 1873-3913 UR - https://www.unboundmedicine.com/medline/citation/19049864/Biochemical_and_functional_properties_of_the_store_operated_Ca2+_channels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0898-6568(08)00337-9 DB - PRIME DP - Unbound Medicine ER -