Tags

Type your tag names separated by a space and hit enter

The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats.
Learn Mem. 2008 Dec; 15(12):857-65.LM

Abstract

Recent research suggests that drug-related memories are reactivated after exposure to environmental cues and may undergo reconsolidation, a process that can strengthen memories. Conversely, reconsolidation may be disrupted by certain pharmacological agents such that the drug-associated memory is weakened. Several studies have demonstrated disruption of memory reconsolidation using a drug-induced conditioned place preference (CPP) task, but no studies have explored whether cocaine-associated memories can be similarly disrupted in cocaine self-administering animals after a cocaine priming injection, which powerfully reinstates drug-seeking behavior. Here we used cocaine-induced CPP and cocaine self-administration to investigate whether the N-methyl-D-aspartate receptor antagonist (+)-5methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) given just prior to reactivation sessions would suppress subsequent cocaine-primed reinstatement (disruption of reconsolidation). Systemic injection of MK-801 (0.05 or 0.20 mg/kg administered intraperitoneally) in rats just prior to reactivation of the cocaine-associated memory in the CPP context attenuated subsequent cocaine-primed reinstatement, while no disruption occurred in rats that did not receive reactivation in the CPP context. However, in rats trained to self-administer cocaine, systemic administration of MK-801 just prior to either of two different types of reactivation sessions had no effect on subsequent cocaine-primed reinstatement of lever-pressing behavior. Thus, systemic administration of MK-801 disrupted the reconsolidation of a cocaine-associated memory for CPP but not for self-administration. These findings suggest that cocaine-CPP and self-administration do not use similar neurochemical processes to disrupt reconsolidation or that cocaine-associated memories in self-administering rats do not undergo reconsolidation, as assessed by lever-pressing behavior under cocaine reinstatement conditions.

Authors+Show Affiliations

Alcohol and Drug Abuse Research Program and Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164-6520, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19050157

Citation

Brown, Travis E., et al. "The NMDA Antagonist MK-801 Disrupts Reconsolidation of a Cocaine-associated Memory for Conditioned Place Preference but Not for Self-administration in Rats." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 15, no. 12, 2008, pp. 857-65.
Brown TE, Lee BR, Sorg BA. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem. 2008;15(12):857-65.
Brown, T. E., Lee, B. R., & Sorg, B. A. (2008). The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learning & Memory (Cold Spring Harbor, N.Y.), 15(12), 857-65. https://doi.org/10.1101/lm.1152808
Brown TE, Lee BR, Sorg BA. The NMDA Antagonist MK-801 Disrupts Reconsolidation of a Cocaine-associated Memory for Conditioned Place Preference but Not for Self-administration in Rats. Learn Mem. 2008;15(12):857-65. PubMed PMID: 19050157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. AU - Brown,Travis E, AU - Lee,Brian R, AU - Sorg,Barbara A, Y1 - 2008/12/02/ PY - 2008/12/4/pubmed PY - 2009/4/9/medline PY - 2008/12/4/entrez SP - 857 EP - 65 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 15 IS - 12 N2 - Recent research suggests that drug-related memories are reactivated after exposure to environmental cues and may undergo reconsolidation, a process that can strengthen memories. Conversely, reconsolidation may be disrupted by certain pharmacological agents such that the drug-associated memory is weakened. Several studies have demonstrated disruption of memory reconsolidation using a drug-induced conditioned place preference (CPP) task, but no studies have explored whether cocaine-associated memories can be similarly disrupted in cocaine self-administering animals after a cocaine priming injection, which powerfully reinstates drug-seeking behavior. Here we used cocaine-induced CPP and cocaine self-administration to investigate whether the N-methyl-D-aspartate receptor antagonist (+)-5methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) given just prior to reactivation sessions would suppress subsequent cocaine-primed reinstatement (disruption of reconsolidation). Systemic injection of MK-801 (0.05 or 0.20 mg/kg administered intraperitoneally) in rats just prior to reactivation of the cocaine-associated memory in the CPP context attenuated subsequent cocaine-primed reinstatement, while no disruption occurred in rats that did not receive reactivation in the CPP context. However, in rats trained to self-administer cocaine, systemic administration of MK-801 just prior to either of two different types of reactivation sessions had no effect on subsequent cocaine-primed reinstatement of lever-pressing behavior. Thus, systemic administration of MK-801 disrupted the reconsolidation of a cocaine-associated memory for CPP but not for self-administration. These findings suggest that cocaine-CPP and self-administration do not use similar neurochemical processes to disrupt reconsolidation or that cocaine-associated memories in self-administering rats do not undergo reconsolidation, as assessed by lever-pressing behavior under cocaine reinstatement conditions. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/19050157/The_NMDA_antagonist_MK_801_disrupts_reconsolidation_of_a_cocaine_associated_memory_for_conditioned_place_preference_but_not_for_self_administration_in_rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19050157/ DB - PRIME DP - Unbound Medicine ER -