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[Non-alcoholic fatty liver disease in children: a new complication of obesity].
Ned Tijdschr Geneeskd. 2008 Nov 08; 152(45):2443-7.NT

Abstract

Non-alcoholic fatty liver disease (NAFLD) comprises a range of chronic liver diseases from simple steatosis to steatohepatitis and cirrhosis with liver failure. In children, NAFLD is mainly associated with obesity and metabolic syndrome, the results of an unhealthy lifestyle. Insulin resistance and free fatty acids play a key role in the pathogenesis of NAFLD. NAFLD can therefore be seen as a metabolic complication of obesity. Since the prevalence of obesity in Dutch children is increasing, the prevalence of NAFLD in children is expected to increase as well. Prevention of obesity and identification of children with an increased risk of NAFLD are important steps in preventing irreversible liver damage. Lifestyle changes aimed at improving insulin sensitivity through healthy food and sufficient physical activity are essential in the treatment of NAFLD. Pharmacological treatment may have additional value.

Authors+Show Affiliations

Afd. Kindergeneeskunde, Universitair Medisch Centrum Groningen, Beatrix Kinderziekenhuis, Groningen. g.bocca@bkk.umcg.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

19051794

Citation

Bocca, G, et al. "[Non-alcoholic Fatty Liver Disease in Children: a New Complication of Obesity]." Nederlands Tijdschrift Voor Geneeskunde, vol. 152, no. 45, 2008, pp. 2443-7.
Bocca G, Stolk RP, Scheenstra R, et al. [Non-alcoholic fatty liver disease in children: a new complication of obesity]. Ned Tijdschr Geneeskd. 2008;152(45):2443-7.
Bocca, G., Stolk, R. P., Scheenstra, R., & Sauer, P. J. (2008). [Non-alcoholic fatty liver disease in children: a new complication of obesity]. Nederlands Tijdschrift Voor Geneeskunde, 152(45), 2443-7.
Bocca G, et al. [Non-alcoholic Fatty Liver Disease in Children: a New Complication of Obesity]. Ned Tijdschr Geneeskd. 2008 Nov 8;152(45):2443-7. PubMed PMID: 19051794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Non-alcoholic fatty liver disease in children: a new complication of obesity]. AU - Bocca,G, AU - Stolk,R P, AU - Scheenstra,R, AU - Sauer,P J J, PY - 2008/12/5/pubmed PY - 2008/12/30/medline PY - 2008/12/5/entrez SP - 2443 EP - 7 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 152 IS - 45 N2 - Non-alcoholic fatty liver disease (NAFLD) comprises a range of chronic liver diseases from simple steatosis to steatohepatitis and cirrhosis with liver failure. In children, NAFLD is mainly associated with obesity and metabolic syndrome, the results of an unhealthy lifestyle. Insulin resistance and free fatty acids play a key role in the pathogenesis of NAFLD. NAFLD can therefore be seen as a metabolic complication of obesity. Since the prevalence of obesity in Dutch children is increasing, the prevalence of NAFLD in children is expected to increase as well. Prevention of obesity and identification of children with an increased risk of NAFLD are important steps in preventing irreversible liver damage. Lifestyle changes aimed at improving insulin sensitivity through healthy food and sufficient physical activity are essential in the treatment of NAFLD. Pharmacological treatment may have additional value. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/19051794/[Non_alcoholic_fatty_liver_disease_in_children:_a_new_complication_of_obesity]_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -