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Asthma at 8 years of age in children born by caesarean section.
Thorax. 2009 Feb; 64(2):107-13.T

Abstract

BACKGROUND

Caesarean section might be a risk factor for asthma because of delayed microbial colonisation, but the association remains controversial. A study was undertaken to investigate prospectively whether children born by caesarean section are more at risk of having asthma in childhood and sensitisation at the age of 8 years, taking into account the allergic status of the parents.

METHODS

2917 children who participated in a birth cohort study were followed for 8 years. The definition of asthma included wheeze, dyspnoea and prescription of inhaled steroids. In a subgroup (n = 1454), serum IgE antibodies for inhalant and food allergens were measured at 8 years.

RESULTS

In the total study population, 12.4% (n = 362) of the children had asthma at the age of 8 years. Caesarean section, with a total prevalence of 8.5%, was associated with an increased risk of asthma (OR 1.79; 95% CI 1.27 to 2.51). This association was stronger among predisposed children (with two allergic parents: OR 2.91; 95% CI 1.20 to 7.05; with only one: OR 1.86; 95% CI 1.12 to 3.09) than in children with non-allergic parents (OR 1.36; 95% CI 0.77 to 2.42). The association between caesarean section and sensitisation at the age of 8 years was significant only in children of non-allergic parents (OR 2.14; 95% CI 1.16 to 3.98).

CONCLUSIONS

Children born by caesarean section have a higher risk of asthma than those born by vaginal delivery, particularly children of allergic parents. Caesarean section increases the risk for sensitisation to common allergens in children with non-allergic parents only.

Authors+Show Affiliations

Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19052046

Citation

Roduit, C, et al. "Asthma at 8 Years of Age in Children Born By Caesarean Section." Thorax, vol. 64, no. 2, 2009, pp. 107-13.
Roduit C, Scholtens S, de Jongste JC, et al. Asthma at 8 years of age in children born by caesarean section. Thorax. 2009;64(2):107-13.
Roduit, C., Scholtens, S., de Jongste, J. C., Wijga, A. H., Gerritsen, J., Postma, D. S., Brunekreef, B., Hoekstra, M. O., Aalberse, R., & Smit, H. A. (2009). Asthma at 8 years of age in children born by caesarean section. Thorax, 64(2), 107-13. https://doi.org/10.1136/thx.2008.100875
Roduit C, et al. Asthma at 8 Years of Age in Children Born By Caesarean Section. Thorax. 2009;64(2):107-13. PubMed PMID: 19052046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asthma at 8 years of age in children born by caesarean section. AU - Roduit,C, AU - Scholtens,S, AU - de Jongste,J C, AU - Wijga,A H, AU - Gerritsen,J, AU - Postma,D S, AU - Brunekreef,B, AU - Hoekstra,M O, AU - Aalberse,R, AU - Smit,H A, Y1 - 2008/12/03/ PY - 2008/12/5/pubmed PY - 2009/2/24/medline PY - 2008/12/5/entrez SP - 107 EP - 13 JF - Thorax JO - Thorax VL - 64 IS - 2 N2 - BACKGROUND: Caesarean section might be a risk factor for asthma because of delayed microbial colonisation, but the association remains controversial. A study was undertaken to investigate prospectively whether children born by caesarean section are more at risk of having asthma in childhood and sensitisation at the age of 8 years, taking into account the allergic status of the parents. METHODS: 2917 children who participated in a birth cohort study were followed for 8 years. The definition of asthma included wheeze, dyspnoea and prescription of inhaled steroids. In a subgroup (n = 1454), serum IgE antibodies for inhalant and food allergens were measured at 8 years. RESULTS: In the total study population, 12.4% (n = 362) of the children had asthma at the age of 8 years. Caesarean section, with a total prevalence of 8.5%, was associated with an increased risk of asthma (OR 1.79; 95% CI 1.27 to 2.51). This association was stronger among predisposed children (with two allergic parents: OR 2.91; 95% CI 1.20 to 7.05; with only one: OR 1.86; 95% CI 1.12 to 3.09) than in children with non-allergic parents (OR 1.36; 95% CI 0.77 to 2.42). The association between caesarean section and sensitisation at the age of 8 years was significant only in children of non-allergic parents (OR 2.14; 95% CI 1.16 to 3.98). CONCLUSIONS: Children born by caesarean section have a higher risk of asthma than those born by vaginal delivery, particularly children of allergic parents. Caesarean section increases the risk for sensitisation to common allergens in children with non-allergic parents only. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/19052046/Asthma_at_8_years_of_age_in_children_born_by_caesarean_section_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=19052046 DB - PRIME DP - Unbound Medicine ER -