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Donovanosis with auto-amputation of penis in a HIV-2 infected person.
Indian J Dermatol Venereol Leprol. 2008 Sep-Oct; 74(5):490-2.IJ

Abstract

Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency.

Authors+Show Affiliations

Department of STD, Rangaraya Medical College, Government General Hospital, Kakinada, Andhra Pradesh, India. drchandragupta_ts@rediffmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19052412

Citation

Chandra Gupta, T S., et al. "Donovanosis With Auto-amputation of Penis in a HIV-2 Infected Person." Indian Journal of Dermatology, Venereology and Leprology, vol. 74, no. 5, 2008, pp. 490-2.
Chandra Gupta TS, Rayudu T, Murthy SV. Donovanosis with auto-amputation of penis in a HIV-2 infected person. Indian J Dermatol Venereol Leprol. 2008;74(5):490-2.
Chandra Gupta, T. S., Rayudu, T., & Murthy, S. V. (2008). Donovanosis with auto-amputation of penis in a HIV-2 infected person. Indian Journal of Dermatology, Venereology and Leprology, 74(5), 490-2.
Chandra Gupta TS, Rayudu T, Murthy SV. Donovanosis With Auto-amputation of Penis in a HIV-2 Infected Person. Indian J Dermatol Venereol Leprol. 2008 Sep-Oct;74(5):490-2. PubMed PMID: 19052412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Donovanosis with auto-amputation of penis in a HIV-2 infected person. AU - Chandra Gupta,T S, AU - Rayudu,Thrimurthulu, AU - Murthy,Srinivasa V, PY - 2008/12/5/pubmed PY - 2009/8/12/medline PY - 2008/12/5/entrez SP - 490 EP - 2 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 74 IS - 5 N2 - Donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by Klebsiella (Calymmatobacterium) granulomatis. The disease is known to persist for years together, leading to complications. A male patient aged 30 years with underlying HIV-2 infection presented to the department of STD with painful ulceration over the genital region of 5 months duration, with absence of penis. Tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellular Donovan bodies (Pund cell). A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. The old conventional medicines, viz. streptomycin, doxycycline and amoxycillin, were effective. Though HIV-2 infections are milder than HIV-1 infections in all aspects, donovanosis in this HIV-2 infected case presented with complications. However, since the CD4 count was 748 cells/cmm, the severity is attributed to the long standing nature and negligence by the patient, and not to possible immunodeficiency. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/19052412/Donovanosis_with_auto-amputation_of_penis_in_a_HIV-2_infected_person. L2 - http://www.ijdvl.com/article.asp?issn=0378-6323;year=2008;volume=74;issue=5;spage=490;epage=492;aulast=Chandra DB - PRIME DP - Unbound Medicine ER -