Tags

Type your tag names separated by a space and hit enter

Stage-independent and stage-specific phenotypic differences between vascular dementia and Alzheimer's Disease.
Dement Geriatr Cogn Disord. 2008; 26(6):513-21.DG

Abstract

AIMS

We examined the effect of stratification by dementia severity on clinical and neuropsychological differences observed between vascular dementia (VaD) and Alzheimer's disease (AD) to ascertain whether any observed phenotypic differences would differ between the early and late stages.

METHODS

The phenotypic features at presentation of 219 newly diagnosed VaD (n = 103) and AD (n = 116) patients were analyzed. All patients underwent clinical, neuropsychological and neuroimaging evaluation. Severity of dementia was staged using the Clinical Dementia Rating (CDR) scale.

RESULTS

VaD can be clinically distinguished from AD by criterion-related features that span across all stages of dementia. We also identified non-criterion-related features that differed according to dementia severity. In the CDR 0.5-1 stage, VaD patients demonstrated increased reading difficulty, loss of insight, apathy, and greater impairment in executive function compared with delayed and recognition memory. Unique distinguishing features for VaD in the CDR 2-3 stage included higher Geriatric Depression Scale scores, lower Barthel scores, gait apraxia and parkinsonism.

CONCLUSIONS

Phenotypic differences between VaD and AD can be conceptualized as either criterion-related stage-independent features, or stage-specific features (comprising cognitive and neuropsychological elements in the mild stages, and physical, affective and functional components in the later stages).

Authors+Show Affiliations

Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore. peng_chew_chan@ttsh.com.sgNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19052451

Citation

Chan, Mark, et al. "Stage-independent and Stage-specific Phenotypic Differences Between Vascular Dementia and Alzheimer's Disease." Dementia and Geriatric Cognitive Disorders, vol. 26, no. 6, 2008, pp. 513-21.
Chan M, Lim WS, Sahadevan S. Stage-independent and stage-specific phenotypic differences between vascular dementia and Alzheimer's Disease. Dement Geriatr Cogn Disord. 2008;26(6):513-21.
Chan, M., Lim, W. S., & Sahadevan, S. (2008). Stage-independent and stage-specific phenotypic differences between vascular dementia and Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders, 26(6), 513-21. https://doi.org/10.1159/000178755
Chan M, Lim WS, Sahadevan S. Stage-independent and Stage-specific Phenotypic Differences Between Vascular Dementia and Alzheimer's Disease. Dement Geriatr Cogn Disord. 2008;26(6):513-21. PubMed PMID: 19052451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stage-independent and stage-specific phenotypic differences between vascular dementia and Alzheimer's Disease. AU - Chan,Mark, AU - Lim,Wee Shiong, AU - Sahadevan,Suresh, Y1 - 2008/12/02/ PY - 2008/09/12/accepted PY - 2008/12/5/pubmed PY - 2009/4/11/medline PY - 2008/12/5/entrez SP - 513 EP - 21 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 26 IS - 6 N2 - AIMS: We examined the effect of stratification by dementia severity on clinical and neuropsychological differences observed between vascular dementia (VaD) and Alzheimer's disease (AD) to ascertain whether any observed phenotypic differences would differ between the early and late stages. METHODS: The phenotypic features at presentation of 219 newly diagnosed VaD (n = 103) and AD (n = 116) patients were analyzed. All patients underwent clinical, neuropsychological and neuroimaging evaluation. Severity of dementia was staged using the Clinical Dementia Rating (CDR) scale. RESULTS: VaD can be clinically distinguished from AD by criterion-related features that span across all stages of dementia. We also identified non-criterion-related features that differed according to dementia severity. In the CDR 0.5-1 stage, VaD patients demonstrated increased reading difficulty, loss of insight, apathy, and greater impairment in executive function compared with delayed and recognition memory. Unique distinguishing features for VaD in the CDR 2-3 stage included higher Geriatric Depression Scale scores, lower Barthel scores, gait apraxia and parkinsonism. CONCLUSIONS: Phenotypic differences between VaD and AD can be conceptualized as either criterion-related stage-independent features, or stage-specific features (comprising cognitive and neuropsychological elements in the mild stages, and physical, affective and functional components in the later stages). SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19052451/Stage_independent_and_stage_specific_phenotypic_differences_between_vascular_dementia_and_Alzheimer's_Disease_ L2 - https://www.karger.com?DOI=10.1159/000178755 DB - PRIME DP - Unbound Medicine ER -