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Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities.
J Nat Prod. 2008 Dec; 71(12):2015-20.JN

Abstract

Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Triana J
Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.
Eiroa JL
No affiliation info available
Ortega JJ
No affiliation info available
León F
No affiliation info available
Brouard I
No affiliation info available
Torres F
No affiliation info available
Quintana J
No affiliation info available
Estévez F
No affiliation info available
Bermejo J
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeDrug Screening Assays, AntitumorHL-60 CellsHumansLactonesMolecular StructurePlants, MedicinalSesquiterpenesSpainU937 Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19053514

Citation

Triana, Jorge, et al. "Sesquiterpene Lactones From Gonospermum Gomerae and G. Fruticosum and Their Cytotoxic Activities." Journal of Natural Products, vol. 71, no. 12, 2008, pp. 2015-20.
Triana J, Eiroa JL, Ortega JJ, et al. Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. J Nat Prod. 2008;71(12):2015-20.
Triana, J., Eiroa, J. L., Ortega, J. J., León, F., Brouard, I., Torres, F., Quintana, J., Estévez, F., & Bermejo, J. (2008). Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. Journal of Natural Products, 71(12), 2015-20. https://doi.org/10.1021/np800474v
Triana J, et al. Sesquiterpene Lactones From Gonospermum Gomerae and G. Fruticosum and Their Cytotoxic Activities. J Nat Prod. 2008;71(12):2015-20. PubMed PMID: 19053514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities. AU - Triana,Jorge, AU - Eiroa,José Luis, AU - Ortega,Juan José, AU - León,Francisco, AU - Brouard,Ignacio, AU - Torres,Fernando, AU - Quintana,José, AU - Estévez,Francisco, AU - Bermejo,Jaime, PY - 2008/12/5/pubmed PY - 2009/1/29/medline PY - 2008/12/5/entrez SP - 2015 EP - 20 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 12 N2 - Four new sesquiterpene lactones (1-4) and a new sesquiterpene (5) together with 20 known compounds were isolated from two Gonospermum species (G. gomerae Bolle and G. fruticosum Less). Their structures were determined by analysis of spectroscopic data, including 1D and 2D NMR. The cytotoxicity of several new and known natural and semisynthetic sesquiterpene lactones was also assessed against human myeloid leukemia cell lines (HL-60 and U937), human melanoma cells (SK-MEL-1), and human adenocarcinoma (A549). SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19053514/Sesquiterpene_lactones_from_Gonospermum_gomerae_and_G__fruticosum_and_their_cytotoxic_activities_ DB - PRIME DP - Unbound Medicine ER -