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Ferulic acid inhibits 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
J Med Food. 2008 Dec; 11(4):693-700.JM

Abstract

The aim of this study was to assess the chemopreventive efficacy of ferulic acid in 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. We induced oral squamous cell carcinoma in the buccal pouch of male Syrian golden hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. The tumor incidence, tumor volume, and tumor burden that were formed in the hamster buccal pouch were determined. The activities of carcinogen detoxification agents and status of lipid peroxidation and antioxidants were also estimated by specific colorimetric methods. We observed 100% tumor formation in DMBA-painted animals. The status of carcinogen-detoxifying agents, lipid peroxidation, and antioxidants was significantly disrupted in DMBA-painted animals. Oral administration of ferulic acid at a dose of 40 mg/kg of body weight to DMBA-painted animals on days alternate to DMBA painting for 14 weeks significantly prevented the tumor incidence, tumor volume, and tumor burden. Ferulic acid exhibited potent anti-lipid peroxidative effects as well as the ability to modulate the status of carcinogen-detoxifying agents and antioxidants in DMBA-painted animals. Our results demonstrate that ferulic acid has potent chemopreventive and antioxidant functions in DMBA-induced hamster buccal pouch carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19053862

Citation

Balakrishnan, Subramanian, et al. "Ferulic Acid Inhibits 7,12-dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis." Journal of Medicinal Food, vol. 11, no. 4, 2008, pp. 693-700.
Balakrishnan S, Menon VP, Manoharan S. Ferulic acid inhibits 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. J Med Food. 2008;11(4):693-700.
Balakrishnan, S., Menon, V. P., & Manoharan, S. (2008). Ferulic acid inhibits 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Journal of Medicinal Food, 11(4), 693-700. https://doi.org/10.1089/jmf.2007.0103
Balakrishnan S, Menon VP, Manoharan S. Ferulic Acid Inhibits 7,12-dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis. J Med Food. 2008;11(4):693-700. PubMed PMID: 19053862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ferulic acid inhibits 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. AU - Balakrishnan,Subramanian, AU - Menon,Venugopal P, AU - Manoharan,Shanmugam, PY - 2008/12/5/pubmed PY - 2009/2/6/medline PY - 2008/12/5/entrez SP - 693 EP - 700 JF - Journal of medicinal food JO - J Med Food VL - 11 IS - 4 N2 - The aim of this study was to assess the chemopreventive efficacy of ferulic acid in 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. We induced oral squamous cell carcinoma in the buccal pouch of male Syrian golden hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. The tumor incidence, tumor volume, and tumor burden that were formed in the hamster buccal pouch were determined. The activities of carcinogen detoxification agents and status of lipid peroxidation and antioxidants were also estimated by specific colorimetric methods. We observed 100% tumor formation in DMBA-painted animals. The status of carcinogen-detoxifying agents, lipid peroxidation, and antioxidants was significantly disrupted in DMBA-painted animals. Oral administration of ferulic acid at a dose of 40 mg/kg of body weight to DMBA-painted animals on days alternate to DMBA painting for 14 weeks significantly prevented the tumor incidence, tumor volume, and tumor burden. Ferulic acid exhibited potent anti-lipid peroxidative effects as well as the ability to modulate the status of carcinogen-detoxifying agents and antioxidants in DMBA-painted animals. Our results demonstrate that ferulic acid has potent chemopreventive and antioxidant functions in DMBA-induced hamster buccal pouch carcinogenesis. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/19053862/Ferulic_acid_inhibits_712_dimethylbenz[a]anthracene_induced_hamster_buccal_pouch_carcinogenesis_ L2 - https://www.liebertpub.com/doi/10.1089/jmf.2007.0103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -