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Continuous distal oesophageal acidification decreases postprandial gastric acidity in healthy human subjects.
Aliment Pharmacol Ther 2009; 29(5):561-70AP

Abstract

BACKGROUND

Previously, we hypothesized that exposing the distal oesophagus to acid signals the stomach to decrease gastric acidity.

AIM

To test the hypothesis that exposing the distal oesophagus to acid signals the stomach to decrease gastric acidity.

METHODS

Twenty-two healthy humans ingested a standard meal containing [(14)C]octanoic acid and [(13)C]glycine over 30 min on 2 separate occasions. Gastric pH was measured for 90 min before and 240 min after the meal. 10 mm HCl was infused continuously at 1 mL/min into either the distal oesophagus or stomach in a 2-way crossover fashion for 60 min before and 240 min after the meal. Gastric emptying of solid and liquid were determined with breath tests.

RESULTS

Compared to gastric infusion, oesophageal infusion significantly decreased gastric acidity after the meal, but not before the meal and the magnitude of the decrease varied directly with gastric acidity. Gastric emptying of solid or liquid with oesophageal infusion was not significantly different from that with gastric infusion.

CONCLUSIONS

These findings support the hypothesis of the existence of a physiological oesophago-gastric feedback mechanism that might contribute to regulation of postprandial gastric acidity. Oesophageal acidification might decode gastric information and signal the stomach to decrease gastric acidity. Further studies are needed to assess the characteristics of such feedback mechanism in-patients with gastro-oesophageal reflux disease (GERD).

Authors+Show Affiliations

Center for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19053984

Citation

Blondeau, K, et al. "Continuous Distal Oesophageal Acidification Decreases Postprandial Gastric Acidity in Healthy Human Subjects." Alimentary Pharmacology & Therapeutics, vol. 29, no. 5, 2009, pp. 561-70.
Blondeau K, Sifrim D, Gardner JD. Continuous distal oesophageal acidification decreases postprandial gastric acidity in healthy human subjects. Aliment Pharmacol Ther. 2009;29(5):561-70.
Blondeau, K., Sifrim, D., & Gardner, J. D. (2009). Continuous distal oesophageal acidification decreases postprandial gastric acidity in healthy human subjects. Alimentary Pharmacology & Therapeutics, 29(5), pp. 561-70. doi:10.1111/j.1365-2036.2008.03907.x.
Blondeau K, Sifrim D, Gardner JD. Continuous Distal Oesophageal Acidification Decreases Postprandial Gastric Acidity in Healthy Human Subjects. Aliment Pharmacol Ther. 2009 Mar 1;29(5):561-70. PubMed PMID: 19053984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous distal oesophageal acidification decreases postprandial gastric acidity in healthy human subjects. AU - Blondeau,K, AU - Sifrim,D, AU - Gardner,J D, Y1 - 2008/11/28/ PY - 2008/12/5/pubmed PY - 2009/7/7/medline PY - 2008/12/5/entrez SP - 561 EP - 70 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 29 IS - 5 N2 - BACKGROUND: Previously, we hypothesized that exposing the distal oesophagus to acid signals the stomach to decrease gastric acidity. AIM: To test the hypothesis that exposing the distal oesophagus to acid signals the stomach to decrease gastric acidity. METHODS: Twenty-two healthy humans ingested a standard meal containing [(14)C]octanoic acid and [(13)C]glycine over 30 min on 2 separate occasions. Gastric pH was measured for 90 min before and 240 min after the meal. 10 mm HCl was infused continuously at 1 mL/min into either the distal oesophagus or stomach in a 2-way crossover fashion for 60 min before and 240 min after the meal. Gastric emptying of solid and liquid were determined with breath tests. RESULTS: Compared to gastric infusion, oesophageal infusion significantly decreased gastric acidity after the meal, but not before the meal and the magnitude of the decrease varied directly with gastric acidity. Gastric emptying of solid or liquid with oesophageal infusion was not significantly different from that with gastric infusion. CONCLUSIONS: These findings support the hypothesis of the existence of a physiological oesophago-gastric feedback mechanism that might contribute to regulation of postprandial gastric acidity. Oesophageal acidification might decode gastric information and signal the stomach to decrease gastric acidity. Further studies are needed to assess the characteristics of such feedback mechanism in-patients with gastro-oesophageal reflux disease (GERD). SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19053984/Continuous_distal_oesophageal_acidification_decreases_postprandial_gastric_acidity_in_healthy_human_subjects_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03907.x DB - PRIME DP - Unbound Medicine ER -