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Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study.
J Am Geriatr Soc 2009; 57(1):11-7JA

Abstract

OBJECTIVES

To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4).

DESIGN

Randomized, double-blind, placebo-controlled trial.

SETTING

Specialist memory clinics in the Stockholm catchment area.

PARTICIPANTS

Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD.

INTERVENTION

Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months.

MEASUREMENTS

Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver.

RESULTS

Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up.

CONCLUSION

A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.

Authors+Show Affiliations

Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden. gerd.faxen.irving@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19054188

Citation

Irving, Gerd Faxén, et al. "Omega-3 Fatty Acid Supplementation Effects On Weight and Appetite in Patients With Alzheimer's Disease: the Omega-3 Alzheimer's Disease Study." Journal of the American Geriatrics Society, vol. 57, no. 1, 2009, pp. 11-7.
Irving GF, Freund-Levi Y, Eriksdotter-Jönhagen M, et al. Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. J Am Geriatr Soc. 2009;57(1):11-7.
Irving, G. F., Freund-Levi, Y., Eriksdotter-Jönhagen, M., Basun, H., Brismar, K., Hjorth, E., ... Cederholm, T. (2009). Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. Journal of the American Geriatrics Society, 57(1), pp. 11-7. doi:10.1111/j.1532-5415.2008.02055.x.
Irving GF, et al. Omega-3 Fatty Acid Supplementation Effects On Weight and Appetite in Patients With Alzheimer's Disease: the Omega-3 Alzheimer's Disease Study. J Am Geriatr Soc. 2009;57(1):11-7. PubMed PMID: 19054188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. AU - Irving,Gerd Faxén, AU - Freund-Levi,Yvonne, AU - Eriksdotter-Jönhagen,Maria, AU - Basun,Hans, AU - Brismar,Kerstin, AU - Hjorth,Erik, AU - Palmblad,Jan, AU - Vessby,Bengt, AU - Vedin,Inger, AU - Wahlund,Lars-Olof, AU - Cederholm,Tommy, Y1 - 2008/11/20/ PY - 2008/12/5/pubmed PY - 2009/3/7/medline PY - 2008/12/5/entrez SP - 11 EP - 7 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 57 IS - 1 N2 - OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/19054188/Omega_3_fatty_acid_supplementation_effects_on_weight_and_appetite_in_patients_with_Alzheimer's_disease:_the_omega_3_Alzheimer's_disease_study_ L2 - https://doi.org/10.1111/j.1532-5415.2008.02055.x DB - PRIME DP - Unbound Medicine ER -