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Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study.

Abstract

OBJECTIVES

To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4).

DESIGN

Randomized, double-blind, placebo-controlled trial.

SETTING

Specialist memory clinics in the Stockholm catchment area.

PARTICIPANTS

Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD.

INTERVENTION

Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months.

MEASUREMENTS

Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver.

RESULTS

Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up.

CONCLUSION

A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.

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  • Authors+Show Affiliations

    ,

    Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden. gerd.faxen.irving@ki.se

    , , , , , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoprotein E4
    Appetite
    Biomarkers
    Body Weight
    Dietary Supplements
    Fatty Acids, Omega-3
    Female
    Humans
    Male

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19054188

    Citation

    Irving, Gerd Faxén, et al. "Omega-3 Fatty Acid Supplementation Effects On Weight and Appetite in Patients With Alzheimer's Disease: the Omega-3 Alzheimer's Disease Study." Journal of the American Geriatrics Society, vol. 57, no. 1, 2009, pp. 11-7.
    Irving GF, Freund-Levi Y, Eriksdotter-Jönhagen M, et al. Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. J Am Geriatr Soc. 2009;57(1):11-7.
    Irving, G. F., Freund-Levi, Y., Eriksdotter-Jönhagen, M., Basun, H., Brismar, K., Hjorth, E., ... Cederholm, T. (2009). Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. Journal of the American Geriatrics Society, 57(1), pp. 11-7. doi:10.1111/j.1532-5415.2008.02055.x.
    Irving GF, et al. Omega-3 Fatty Acid Supplementation Effects On Weight and Appetite in Patients With Alzheimer's Disease: the Omega-3 Alzheimer's Disease Study. J Am Geriatr Soc. 2009;57(1):11-7. PubMed PMID: 19054188.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. AU - Irving,Gerd Faxén, AU - Freund-Levi,Yvonne, AU - Eriksdotter-Jönhagen,Maria, AU - Basun,Hans, AU - Brismar,Kerstin, AU - Hjorth,Erik, AU - Palmblad,Jan, AU - Vessby,Bengt, AU - Vedin,Inger, AU - Wahlund,Lars-Olof, AU - Cederholm,Tommy, Y1 - 2008/11/20/ PY - 2008/12/5/pubmed PY - 2009/3/7/medline PY - 2008/12/5/entrez SP - 11 EP - 7 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 57 IS - 1 N2 - OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/19054188/Omega_3_fatty_acid_supplementation_effects_on_weight_and_appetite_in_patients_with_Alzheimer's_disease:_the_omega_3_Alzheimer's_disease_study_ L2 - https://doi.org/10.1111/j.1532-5415.2008.02055.x DB - PRIME DP - Unbound Medicine ER -