Tags

Type your tag names separated by a space and hit enter

Genomic analysis of the smallest giant virus--Feldmannia sp. virus 158.
Virology. 2009 Feb 05; 384(1):223-32.V

Abstract

Genomic analysis of Feldmannia sp. virus 158, the second phaeovirus to be sequenced in its entirety, provides further evidence that large double-stranded DNA viruses share similar evolutionary pressures as cellular organisms. Reductive evolution is clearly evident within the phaeoviruses which occurred via several routes: the loss of genes from an ancestral virus core genome most likely through genetic drift; and as a result of relatively large recombination events that caused wholesale loss of genes. The entire genome is 154,641 bp in length and has 150 predicted coding sequences of which 87% have amino acid sequence similarities to other algal virus coding sequences within the family Phycodnaviridae. Significant similarities were found, for thirty eight coding sequences (25%), to genes in gene databanks that are known to be involved in processes that include DNA replication, DNA methylation, signal transduction, viral integration and transposition, and protein-protein interactions. Unsurprisingly, the greatest similarity was observed between the two known viruses that infect Feldmannia, indicating the taxonomic linkage of these two viruses with their hosts. Moreover, comparative analysis of phycodnaviral genomic sequences revealed the smallest set of core genes (10 out of a possible 31) required to make a functional nucleocytoplasmic large dsDNA virus.

Links

Aggregator Full Text
Publisher Full Text
linkinghub.elsevier.com
linkinghub.elsevier.com

Authors+Show Affiliations

Schroeder DC
Marine Biological Association, Citadel Hill, Plymouth, UK.
Park Y
No affiliation info available
Yoon HM
No affiliation info available
Lee YS
No affiliation info available
Kang SW
No affiliation info available
Meints RH
No affiliation info available
Ivey RG
No affiliation info available
Choi TJ
No affiliation info available

MeSH

Base SequenceDNADNA ReplicationDNA VirusesDNA, ViralEvolution, MolecularGenome, ViralMolecular Sequence DataPhaeophytaPhycodnaviridaeReplication OriginSequence AlignmentSequence Homology, Nucleic AcidViruses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19054537

Citation

Schroeder, Declan C., et al. "Genomic Analysis of the Smallest Giant virus--Feldmannia Sp. Virus 158." Virology, vol. 384, no. 1, 2009, pp. 223-32.
Schroeder DC, Park Y, Yoon HM, et al. Genomic analysis of the smallest giant virus--Feldmannia sp. virus 158. Virology. 2009;384(1):223-32.
Schroeder, D. C., Park, Y., Yoon, H. M., Lee, Y. S., Kang, S. W., Meints, R. H., Ivey, R. G., & Choi, T. J. (2009). Genomic analysis of the smallest giant virus--Feldmannia sp. virus 158. Virology, 384(1), 223-32. https://doi.org/10.1016/j.virol.2008.10.040
Schroeder DC, et al. Genomic Analysis of the Smallest Giant virus--Feldmannia Sp. Virus 158. Virology. 2009 Feb 5;384(1):223-32. PubMed PMID: 19054537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genomic analysis of the smallest giant virus--Feldmannia sp. virus 158. AU - Schroeder,Declan C, AU - Park,Yunjung, AU - Yoon,Hong-Mook, AU - Lee,Yong Seok, AU - Kang,Se Won, AU - Meints,Russel H, AU - Ivey,Richard G, AU - Choi,Tae-Jin, Y1 - 2008/12/02/ PY - 2008/09/15/received PY - 2008/10/08/revised PY - 2008/10/29/accepted PY - 2008/12/5/pubmed PY - 2009/2/24/medline PY - 2008/12/5/entrez SP - 223 EP - 32 JF - Virology JO - Virology VL - 384 IS - 1 N2 - Genomic analysis of Feldmannia sp. virus 158, the second phaeovirus to be sequenced in its entirety, provides further evidence that large double-stranded DNA viruses share similar evolutionary pressures as cellular organisms. Reductive evolution is clearly evident within the phaeoviruses which occurred via several routes: the loss of genes from an ancestral virus core genome most likely through genetic drift; and as a result of relatively large recombination events that caused wholesale loss of genes. The entire genome is 154,641 bp in length and has 150 predicted coding sequences of which 87% have amino acid sequence similarities to other algal virus coding sequences within the family Phycodnaviridae. Significant similarities were found, for thirty eight coding sequences (25%), to genes in gene databanks that are known to be involved in processes that include DNA replication, DNA methylation, signal transduction, viral integration and transposition, and protein-protein interactions. Unsurprisingly, the greatest similarity was observed between the two known viruses that infect Feldmannia, indicating the taxonomic linkage of these two viruses with their hosts. Moreover, comparative analysis of phycodnaviral genomic sequences revealed the smallest set of core genes (10 out of a possible 31) required to make a functional nucleocytoplasmic large dsDNA virus. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/19054537/Genomic_analysis_of_the_smallest_giant_virus__Feldmannia_sp__virus_158_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(08)00717-4 DB - PRIME DP - Unbound Medicine ER -