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A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women.
Age Ageing 2009; 38(1):86-93AA

Abstract

BACKGROUND

a small number of reports exist on the cognitive effects of soy isoflavones, the findings from which are mixed. Isoflavone efficacy is dependent upon conversion of glycosides contained in soy foods and supplements to the biologically active aglycons. Of particular interest is the production of the metabolite, equol, which is dependent upon intestinal microflora and an integrous digestive system, both being altered by age and age-associated conditions. Unfortunately, few studies enrolled adults over the age of 70, and none included older men.

OBJECTIVE

we examined safety, feasibility and cognitive efficacy of soy isoflavone administration in older nondemented men and women (age 62-89 years).

DESIGN AND METHODS

in this randomised, placebo-controlled, double-blind pilot study, subjects ingested either 100 mg/day soy isoflavones (glycoside weight) or matching placebo tablets for 6 months.

RESULTS

active and placebo-treated subjects exhibited a comparable side-effect profile. Plasma levels of genistein and daidzein (P < 0.001), but not equol, increased with isoflavone administration. While similar at baseline, the two groups differed across 6 months of treatment on 8 of 11 cognitive tests administered. Isoflavone-treated subjects improved on tests of visual-spatial memory (P < 0.01) and construction (P = 0.01), verbal fluency (P < 0.01) and speeded dexterity (P = 0.04). Placebo-treated participants were faster than isoflavone-treated subjects on two tests of executive function (P < 0.05).

CONCLUSIONS

these data suggest that administration of 100 mg/day of isoflavones was well tolerated. Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration. Finally, data support the potential cognitive effects of soy isoflavones in older adults.

Authors+Show Affiliations

Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA. ceg@medicine.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19054783

Citation

Gleason, Carey E., et al. "A Preliminary Study of the Safety, Feasibility and Cognitive Efficacy of Soy Isoflavone Supplements in Older Men and Women." Age and Ageing, vol. 38, no. 1, 2009, pp. 86-93.
Gleason CE, Carlsson CM, Barnet JH, et al. A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age Ageing. 2009;38(1):86-93.
Gleason, C. E., Carlsson, C. M., Barnet, J. H., Meade, S. A., Setchell, K. D., Atwood, C. S., ... Asthana, S. (2009). A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. Age and Ageing, 38(1), pp. 86-93. doi:10.1093/ageing/afn227.
Gleason CE, et al. A Preliminary Study of the Safety, Feasibility and Cognitive Efficacy of Soy Isoflavone Supplements in Older Men and Women. Age Ageing. 2009;38(1):86-93. PubMed PMID: 19054783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women. AU - Gleason,Carey E, AU - Carlsson,Cynthia M, AU - Barnet,Jodi H, AU - Meade,Sarah A, AU - Setchell,Kenneth D R, AU - Atwood,Craig S, AU - Johnson,Sterling C, AU - Ries,Michele L, AU - Asthana,Sanjay, Y1 - 2008/12/02/ PY - 2008/12/5/pubmed PY - 2009/4/14/medline PY - 2008/12/5/entrez SP - 86 EP - 93 JF - Age and ageing JO - Age Ageing VL - 38 IS - 1 N2 - BACKGROUND: a small number of reports exist on the cognitive effects of soy isoflavones, the findings from which are mixed. Isoflavone efficacy is dependent upon conversion of glycosides contained in soy foods and supplements to the biologically active aglycons. Of particular interest is the production of the metabolite, equol, which is dependent upon intestinal microflora and an integrous digestive system, both being altered by age and age-associated conditions. Unfortunately, few studies enrolled adults over the age of 70, and none included older men. OBJECTIVE: we examined safety, feasibility and cognitive efficacy of soy isoflavone administration in older nondemented men and women (age 62-89 years). DESIGN AND METHODS: in this randomised, placebo-controlled, double-blind pilot study, subjects ingested either 100 mg/day soy isoflavones (glycoside weight) or matching placebo tablets for 6 months. RESULTS: active and placebo-treated subjects exhibited a comparable side-effect profile. Plasma levels of genistein and daidzein (P < 0.001), but not equol, increased with isoflavone administration. While similar at baseline, the two groups differed across 6 months of treatment on 8 of 11 cognitive tests administered. Isoflavone-treated subjects improved on tests of visual-spatial memory (P < 0.01) and construction (P = 0.01), verbal fluency (P < 0.01) and speeded dexterity (P = 0.04). Placebo-treated participants were faster than isoflavone-treated subjects on two tests of executive function (P < 0.05). CONCLUSIONS: these data suggest that administration of 100 mg/day of isoflavones was well tolerated. Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration. Finally, data support the potential cognitive effects of soy isoflavones in older adults. SN - 1468-2834 UR - https://www.unboundmedicine.com/medline/citation/19054783/A_preliminary_study_of_the_safety_feasibility_and_cognitive_efficacy_of_soy_isoflavone_supplements_in_older_men_and_women_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/afn227 DB - PRIME DP - Unbound Medicine ER -