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Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials.
Ann Allergy Asthma Immunol. 2008 Nov; 101(5):508-16.AA

Abstract

BACKGROUND

Several articles describing the efficacy of probiotics in atopic dermatitis (AD) have been published. However, not all studies support a similar outcome.

OBJECTIVE

To determine whether probiotics are efficacious in treating AD and to explore whether type of probiotic used, duration of therapy, patient age, severity of disease, and IgE sensitization are factors in determining efficacy.

METHODS

For this meta-analysis of randomized controlled trials describing the efficacy of probiotics in AD, a comprehensive search was performed of databases through January 2008. Three reviewers independently evaluated the studies for methodological qualities. All the data were analyzed, and forest plots were evaluated for the overall efficacy of probiotics in AD and the therapeutic benefit to subgroups of selected patient populations.

RESULTS

Eleven studies were identified, and data from 10 studies (n = 678) were available to analyze. There was an overall statistically significant difference favoring probiotics compared with placebo in reducing the Scoring of Atopic Dermatitis Severity Index score (mean change from baseline, -3.01; 95% confidence interval, -5.36 to -0.66; P = .01). Children with moderately severe disease were more likely to benefit. Duration of probiotic administration, age, and type of probiotic used did not affect outcome.

CONCLUSION

Data from this meta-analysis suggest a modestrole for probiotics in pediatric AD. The effect is seen in moderately severe rather than mild disease.

Authors+Show Affiliations

Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45404, USA. sonia.michail@wright.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

19055205

Citation

Michail, Sonia K., et al. "Efficacy of Probiotics in the Treatment of Pediatric Atopic Dermatitis: a Meta-analysis of Randomized Controlled Trials." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 101, no. 5, 2008, pp. 508-16.
Michail SK, Stolfi A, Johnson T, et al. Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol. 2008;101(5):508-16.
Michail, S. K., Stolfi, A., Johnson, T., & Onady, G. M. (2008). Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 101(5), 508-16. https://doi.org/10.1016/S1081-1206(10)60290-6
Michail SK, et al. Efficacy of Probiotics in the Treatment of Pediatric Atopic Dermatitis: a Meta-analysis of Randomized Controlled Trials. Ann Allergy Asthma Immunol. 2008;101(5):508-16. PubMed PMID: 19055205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials. AU - Michail,Sonia K, AU - Stolfi,Adrienne, AU - Johnson,Thomas, AU - Onady,Gary M, PY - 2008/12/6/pubmed PY - 2008/12/31/medline PY - 2008/12/6/entrez SP - 508 EP - 16 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 101 IS - 5 N2 - BACKGROUND: Several articles describing the efficacy of probiotics in atopic dermatitis (AD) have been published. However, not all studies support a similar outcome. OBJECTIVE: To determine whether probiotics are efficacious in treating AD and to explore whether type of probiotic used, duration of therapy, patient age, severity of disease, and IgE sensitization are factors in determining efficacy. METHODS: For this meta-analysis of randomized controlled trials describing the efficacy of probiotics in AD, a comprehensive search was performed of databases through January 2008. Three reviewers independently evaluated the studies for methodological qualities. All the data were analyzed, and forest plots were evaluated for the overall efficacy of probiotics in AD and the therapeutic benefit to subgroups of selected patient populations. RESULTS: Eleven studies were identified, and data from 10 studies (n = 678) were available to analyze. There was an overall statistically significant difference favoring probiotics compared with placebo in reducing the Scoring of Atopic Dermatitis Severity Index score (mean change from baseline, -3.01; 95% confidence interval, -5.36 to -0.66; P = .01). Children with moderately severe disease were more likely to benefit. Duration of probiotic administration, age, and type of probiotic used did not affect outcome. CONCLUSION: Data from this meta-analysis suggest a modestrole for probiotics in pediatric AD. The effect is seen in moderately severe rather than mild disease. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/19055205/Efficacy_of_probiotics_in_the_treatment_of_pediatric_atopic_dermatitis:_a_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60290-6 DB - PRIME DP - Unbound Medicine ER -