Tags

Type your tag names separated by a space and hit enter

Hippocampal modulation of nucleus accumbens: behavioral evidence from amphetamine-induced activity profiles.
Behav Neural Biol 1991; 55(3):289-306BN

Abstract

The experiments examined amphetamine-induced locomotion and stereotyped behavior in hippocampal-ablated and control rats for 30 days following surgery. Locomotor counts, stereotypy ratings, and locomotor-time profiles showed that d-amphetamine sulfate produced a selective enhancement of locomotion (cage crosses) at the expense of stereotyped behavior in hippocampal rats relative to normal control rats. This enhancement emerged over the first 2 weeks postsurgery. To examine the role of the striatum in this amphetamine-induced effect, combined hippocampal damage and 6-hydroxydopamine-induced damage of the nucleus accumbens or caudate-putamen were used. These results suggested that amphetamine-enhanced locomotion of hippocampal rats is dependent upon the integrity of the nucleus accumbens and may reflect a change of nucleus accumbens activity relative to caudate-putamen activity. Together these findings suggest that the hippocampus may participate in the control of locomotion by projections that modulate the activity of the nucleus accumbens.

Authors+Show Affiliations

Department of Psychology, University of Lethbridge, Alberta, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1905533

Citation

Whishaw, I Q., and G Mittleman. "Hippocampal Modulation of Nucleus Accumbens: Behavioral Evidence From Amphetamine-induced Activity Profiles." Behavioral and Neural Biology, vol. 55, no. 3, 1991, pp. 289-306.
Whishaw IQ, Mittleman G. Hippocampal modulation of nucleus accumbens: behavioral evidence from amphetamine-induced activity profiles. Behav Neural Biol. 1991;55(3):289-306.
Whishaw, I. Q., & Mittleman, G. (1991). Hippocampal modulation of nucleus accumbens: behavioral evidence from amphetamine-induced activity profiles. Behavioral and Neural Biology, 55(3), pp. 289-306.
Whishaw IQ, Mittleman G. Hippocampal Modulation of Nucleus Accumbens: Behavioral Evidence From Amphetamine-induced Activity Profiles. Behav Neural Biol. 1991;55(3):289-306. PubMed PMID: 1905533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal modulation of nucleus accumbens: behavioral evidence from amphetamine-induced activity profiles. AU - Whishaw,I Q, AU - Mittleman,G, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 289 EP - 306 JF - Behavioral and neural biology JO - Behav. Neural Biol. VL - 55 IS - 3 N2 - The experiments examined amphetamine-induced locomotion and stereotyped behavior in hippocampal-ablated and control rats for 30 days following surgery. Locomotor counts, stereotypy ratings, and locomotor-time profiles showed that d-amphetamine sulfate produced a selective enhancement of locomotion (cage crosses) at the expense of stereotyped behavior in hippocampal rats relative to normal control rats. This enhancement emerged over the first 2 weeks postsurgery. To examine the role of the striatum in this amphetamine-induced effect, combined hippocampal damage and 6-hydroxydopamine-induced damage of the nucleus accumbens or caudate-putamen were used. These results suggested that amphetamine-enhanced locomotion of hippocampal rats is dependent upon the integrity of the nucleus accumbens and may reflect a change of nucleus accumbens activity relative to caudate-putamen activity. Together these findings suggest that the hippocampus may participate in the control of locomotion by projections that modulate the activity of the nucleus accumbens. SN - 0163-1047 UR - https://www.unboundmedicine.com/medline/citation/1905533/Hippocampal_modulation_of_nucleus_accumbens:_behavioral_evidence_from_amphetamine_induced_activity_profiles_ DB - PRIME DP - Unbound Medicine ER -