Tags

Type your tag names separated by a space and hit enter

Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations.
Am J Clin Nutr. 2009 Jan; 89(1):354-62.AJ

Abstract

BACKGROUND

Because high dietary and blood n-3 (omega-3) fatty acids (FAs) are protective against coronary heart disease and sudden cardiac death, the alcohol-associated increase in blood n-3 FAs could be considered an original mechanism of alcohol's cardioprotective effect.

OBJECTIVE

Our objective was to assess whether alcohol consumption is associated with concentrations of very-long-chain "marine" (eg, fish oil) n-3 FAs both in plasma and in red blood cell membranes.

DESIGN

In the framework of the IMMIDIET (Dietary Habit Profile in European Communities with Different Risk of Myocardial Infarction: the Impact of Migration as a Model of Gene-Environment Interaction) Project, 1604 subjects (802 women-men pairs), aged 26-65 y, were enrolled in Italy, Belgium, and England. A 1-y-recall food-frequency questionnaire was used to evaluate dietary intake.

RESULTS

In fully adjusted multivariate analyses, alcohol intake was positively associated with plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA + DHA concentrations (P < 0.0001, P = 0.036, and P = 0.002, respectively) in women and with EPA and the EPA + DHA index in red blood cells (P < 0.0001 and P = 0.037, respectively). In men, only plasma and red blood cell EPA concentrations were associated with alcohol intake (P = 0.003 and P = 0.004, respectively). Stratified analyses showed an association between alcohol and both plasma and red cell EPA (P = 0.008 and P = 0.002, respectively), DHA (P = 0.014 and P = 0.008, respectively), and the EPA + DHA index (P = 0.010 and P = 0.006, respectively) in wine drinkers, whereas no association was found in those who drink beer and spirits.

CONCLUSIONS

Alcohol intake was associated with higher plasma and red blood cell concentrations of marine n-3 FAs. Components of wine other than alcohol (polyphenols) might exert these effects. Part of the alcohol-induced cardioprotection may be mediated through increased marine n-3 FAs.

Authors+Show Affiliations

Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, John Paul II Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19056552

Citation

di Giuseppe, Romina, et al. "Alcohol Consumption and N-3 Polyunsaturated Fatty Acids in Healthy Men and Women From 3 European Populations." The American Journal of Clinical Nutrition, vol. 89, no. 1, 2009, pp. 354-62.
di Giuseppe R, de Lorgeril M, Salen P, et al. Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations. Am J Clin Nutr. 2009;89(1):354-62.
di Giuseppe, R., de Lorgeril, M., Salen, P., Laporte, F., Di Castelnuovo, A., Krogh, V., Siani, A., Arnout, J., Cappuccio, F. P., van Dongen, M., Donati, M. B., de Gaetano, G., & Iacoviello, L. (2009). Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations. The American Journal of Clinical Nutrition, 89(1), 354-62. https://doi.org/10.3945/ajcn.2008.26661
di Giuseppe R, et al. Alcohol Consumption and N-3 Polyunsaturated Fatty Acids in Healthy Men and Women From 3 European Populations. Am J Clin Nutr. 2009;89(1):354-62. PubMed PMID: 19056552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations. AU - di Giuseppe,Romina, AU - de Lorgeril,Michel, AU - Salen,Patricia, AU - Laporte,François, AU - Di Castelnuovo,Augusto, AU - Krogh,Vittorio, AU - Siani,Alfonso, AU - Arnout,Jozef, AU - Cappuccio,Francesco P, AU - van Dongen,Martien, AU - Donati,Maria Benedetta, AU - de Gaetano,Giovanni, AU - Iacoviello,Licia, AU - ,, Y1 - 2008/12/03/ PY - 2008/12/6/pubmed PY - 2009/2/6/medline PY - 2008/12/6/entrez SP - 354 EP - 62 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 89 IS - 1 N2 - BACKGROUND: Because high dietary and blood n-3 (omega-3) fatty acids (FAs) are protective against coronary heart disease and sudden cardiac death, the alcohol-associated increase in blood n-3 FAs could be considered an original mechanism of alcohol's cardioprotective effect. OBJECTIVE: Our objective was to assess whether alcohol consumption is associated with concentrations of very-long-chain "marine" (eg, fish oil) n-3 FAs both in plasma and in red blood cell membranes. DESIGN: In the framework of the IMMIDIET (Dietary Habit Profile in European Communities with Different Risk of Myocardial Infarction: the Impact of Migration as a Model of Gene-Environment Interaction) Project, 1604 subjects (802 women-men pairs), aged 26-65 y, were enrolled in Italy, Belgium, and England. A 1-y-recall food-frequency questionnaire was used to evaluate dietary intake. RESULTS: In fully adjusted multivariate analyses, alcohol intake was positively associated with plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA + DHA concentrations (P < 0.0001, P = 0.036, and P = 0.002, respectively) in women and with EPA and the EPA + DHA index in red blood cells (P < 0.0001 and P = 0.037, respectively). In men, only plasma and red blood cell EPA concentrations were associated with alcohol intake (P = 0.003 and P = 0.004, respectively). Stratified analyses showed an association between alcohol and both plasma and red cell EPA (P = 0.008 and P = 0.002, respectively), DHA (P = 0.014 and P = 0.008, respectively), and the EPA + DHA index (P = 0.010 and P = 0.006, respectively) in wine drinkers, whereas no association was found in those who drink beer and spirits. CONCLUSIONS: Alcohol intake was associated with higher plasma and red blood cell concentrations of marine n-3 FAs. Components of wine other than alcohol (polyphenols) might exert these effects. Part of the alcohol-induced cardioprotection may be mediated through increased marine n-3 FAs. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19056552/Alcohol_consumption_and_n_3_polyunsaturated_fatty_acids_in_healthy_men_and_women_from_3_European_populations_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26661 DB - PRIME DP - Unbound Medicine ER -