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Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet.
Am J Clin Nutr. 2009 Jan; 89(1):248-56.AJ

Abstract

BACKGROUND

Adherence to the Mediterranean diet (Med-Diet) is associated with a reduced risk of cardiovascular disease (CVD). However, the molecular mechanisms involved are not fully understood.

OBJECTIVE

The objective was to compare the effects of 2 Med-Diets with those of a low-fat diet on immune cell activation and soluble inflammatory biomarkers related to atherogenesis in subjects at high risk of CVD.

DESIGN

In a controlled study, we randomly assigned 112 older subjects with diabetes or > or =3 CVD risk factors to 3 dietary intervention groups: Med-Diet with supplemental virgin olive oil (VOO), Med-Diet with supplemental nuts, and low-fat diet. Changes from baseline in cellular and serum inflammatory biomarkers were assessed at 3 mo.

RESULTS

One hundred six participants (43% women; average age: 68 y) completed the study. At 3 mo, monocyte expression of CD49d, an adhesion molecule crucial for leukocyte homing, and of CD40, a proinflammatory ligand, decreased (P < 0.05) after both Med-Diets but not after the low-fat diet. Serum interleukin-6 and soluble intercellular adhesion molecule-1, inflammatory mediators crucial in firm adhesion of leukocytes to endothelial surfaces, decreased (P < 0.05) in both Med-Diet groups. Soluble vascular cellular adhesion molecule-1 and C-reactive protein decreased only after the Med-Diet with VOO (P < 0.05), whereas interleukin-6, soluble vascular cellular adhesion molecule-1, and soluble intercellular adhesion molecule-1 increased (P < 0.05) after the low-fat diet.

CONCLUSIONS

Med-Diets supplemented with VOO or nuts down-regulate cellular and circulating inflammatory biomarkers related to atherogenesis in subjects at high risk of CVD. The results support the recommendation of the Med-Diet as a useful tool against CVD.

Authors+Show Affiliations

Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Instituto de Salud Carlos III, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19056596

Citation

Mena, Mari-Pau, et al. "Inhibition of Circulating Immune Cell Activation: a Molecular Antiinflammatory Effect of the Mediterranean Diet." The American Journal of Clinical Nutrition, vol. 89, no. 1, 2009, pp. 248-56.
Mena MP, Sacanella E, Vazquez-Agell M, et al. Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet. Am J Clin Nutr. 2009;89(1):248-56.
Mena, M. P., Sacanella, E., Vazquez-Agell, M., Morales, M., Fitó, M., Escoda, R., Serrano-Martínez, M., Salas-Salvadó, J., Benages, N., Casas, R., Lamuela-Raventós, R. M., Masanes, F., Ros, E., & Estruch, R. (2009). Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet. The American Journal of Clinical Nutrition, 89(1), 248-56. https://doi.org/10.3945/ajcn.2008.26094
Mena MP, et al. Inhibition of Circulating Immune Cell Activation: a Molecular Antiinflammatory Effect of the Mediterranean Diet. Am J Clin Nutr. 2009;89(1):248-56. PubMed PMID: 19056596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet. AU - Mena,Mari-Pau, AU - Sacanella,Emilio, AU - Vazquez-Agell,Mónica, AU - Morales,Mercedes, AU - Fitó,Montserrat, AU - Escoda,Rosa, AU - Serrano-Martínez,Manuel, AU - Salas-Salvadó,Jordi, AU - Benages,Neus, AU - Casas,Rosa, AU - Lamuela-Raventós,Rosa M, AU - Masanes,Ferran, AU - Ros,Emilio, AU - Estruch,Ramon, Y1 - 2008/12/03/ PY - 2008/12/6/pubmed PY - 2009/2/6/medline PY - 2008/12/6/entrez SP - 248 EP - 56 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 89 IS - 1 N2 - BACKGROUND: Adherence to the Mediterranean diet (Med-Diet) is associated with a reduced risk of cardiovascular disease (CVD). However, the molecular mechanisms involved are not fully understood. OBJECTIVE: The objective was to compare the effects of 2 Med-Diets with those of a low-fat diet on immune cell activation and soluble inflammatory biomarkers related to atherogenesis in subjects at high risk of CVD. DESIGN: In a controlled study, we randomly assigned 112 older subjects with diabetes or > or =3 CVD risk factors to 3 dietary intervention groups: Med-Diet with supplemental virgin olive oil (VOO), Med-Diet with supplemental nuts, and low-fat diet. Changes from baseline in cellular and serum inflammatory biomarkers were assessed at 3 mo. RESULTS: One hundred six participants (43% women; average age: 68 y) completed the study. At 3 mo, monocyte expression of CD49d, an adhesion molecule crucial for leukocyte homing, and of CD40, a proinflammatory ligand, decreased (P < 0.05) after both Med-Diets but not after the low-fat diet. Serum interleukin-6 and soluble intercellular adhesion molecule-1, inflammatory mediators crucial in firm adhesion of leukocytes to endothelial surfaces, decreased (P < 0.05) in both Med-Diet groups. Soluble vascular cellular adhesion molecule-1 and C-reactive protein decreased only after the Med-Diet with VOO (P < 0.05), whereas interleukin-6, soluble vascular cellular adhesion molecule-1, and soluble intercellular adhesion molecule-1 increased (P < 0.05) after the low-fat diet. CONCLUSIONS: Med-Diets supplemented with VOO or nuts down-regulate cellular and circulating inflammatory biomarkers related to atherogenesis in subjects at high risk of CVD. The results support the recommendation of the Med-Diet as a useful tool against CVD. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19056596/Inhibition_of_circulating_immune_cell_activation:_a_molecular_antiinflammatory_effect_of_the_Mediterranean_diet_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26094 DB - PRIME DP - Unbound Medicine ER -