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Maximizing muscle protein anabolism: the role of protein quality.
Curr Opin Clin Nutr Metab Care. 2009 Jan; 12(1):66-71.CO

Abstract

PURPOSE OF REVIEW

Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in the responses of MPS, and muscle protein accretion, with ingestion of milk-based and soy-based proteins in young and elderly persons.

RECENT FINDINGS

Protein consumption, and the accompanying hyperaminoacidemia, stimulates an increase in MPS and a small suppression of muscle protein breakdown. Beyond the feeding-induced rise in MPS, small incremental addition of new muscle protein mass occurs following intense resistance exercise which over time (i.e. resistance training) leads to muscle hypertrophy. Athletes make use of the paradigm of resistance training and eating to maximize the gains in their skeletal muscle mass. Importantly, however, metabolically active skeletal muscle can offset the morbidities associated with the sarcopenia of aging such as type II diabetes, decline in aerobic fitness and the reduction in metabolic rate that can lead to fat mass accumulation.

SUMMARY

Recent evidence suggests that consumption of different proteins can affect the amplitude and possibly duration of MPS increases after feeding and this effect interacts and is possibly accentuated with resistance exercise.

Authors+Show Affiliations

Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19057190

Citation

Tang, Jason E., and Stuart M. Phillips. "Maximizing Muscle Protein Anabolism: the Role of Protein Quality." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 1, 2009, pp. 66-71.
Tang JE, Phillips SM. Maximizing muscle protein anabolism: the role of protein quality. Curr Opin Clin Nutr Metab Care. 2009;12(1):66-71.
Tang, J. E., & Phillips, S. M. (2009). Maximizing muscle protein anabolism: the role of protein quality. Current Opinion in Clinical Nutrition and Metabolic Care, 12(1), 66-71. https://doi.org/10.1097/MCO.0b013e32831cef75
Tang JE, Phillips SM. Maximizing Muscle Protein Anabolism: the Role of Protein Quality. Curr Opin Clin Nutr Metab Care. 2009;12(1):66-71. PubMed PMID: 19057190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maximizing muscle protein anabolism: the role of protein quality. AU - Tang,Jason E, AU - Phillips,Stuart M, PY - 2008/12/6/pubmed PY - 2009/2/12/medline PY - 2008/12/6/entrez SP - 66 EP - 71 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 12 IS - 1 N2 - PURPOSE OF REVIEW: Muscle protein synthesis (MPS) and muscle protein breakdown are simultaneous ongoing processes. Here, we examine evidence for how protein quality can affect exercise-induced muscle protein anabolism or protein balance (MPS minus muscle protein breakdown). Evidence is highlighted showing differences in the responses of MPS, and muscle protein accretion, with ingestion of milk-based and soy-based proteins in young and elderly persons. RECENT FINDINGS: Protein consumption, and the accompanying hyperaminoacidemia, stimulates an increase in MPS and a small suppression of muscle protein breakdown. Beyond the feeding-induced rise in MPS, small incremental addition of new muscle protein mass occurs following intense resistance exercise which over time (i.e. resistance training) leads to muscle hypertrophy. Athletes make use of the paradigm of resistance training and eating to maximize the gains in their skeletal muscle mass. Importantly, however, metabolically active skeletal muscle can offset the morbidities associated with the sarcopenia of aging such as type II diabetes, decline in aerobic fitness and the reduction in metabolic rate that can lead to fat mass accumulation. SUMMARY: Recent evidence suggests that consumption of different proteins can affect the amplitude and possibly duration of MPS increases after feeding and this effect interacts and is possibly accentuated with resistance exercise. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/19057190/Maximizing_muscle_protein_anabolism:_the_role_of_protein_quality_ L2 - http://dx.doi.org/10.1097/MCO.0b013e32831cef75 DB - PRIME DP - Unbound Medicine ER -