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Recent advances in berry supplementation and age-related cognitive decline.
Curr Opin Clin Nutr Metab Care. 2009 Jan; 12(1):91-4.CO

Abstract

PURPOSE OF REVIEW

To summarize recent findings and current concepts in the beneficial effects of berry consumption on brain function during aging.

RECENT FINDINGS

Berryfruit supplementation has continued to demonstrate efficacy in reversing age-related cognitive decline in animal studies. In terms of the mechanisms behind the effects of berries on the central nervous system, recent studies have demonstrated the bioavailability of berry polyphenols in several animal models. These studies have revealed that flavonoids and polyphenols from berries do accumulate in the brain following long-term consumption. Finally, several compelling studies have revealed that berries can influence cell-signaling cascades both in vivo and in cell culture systems. These studies underscore the developing theory that berries and antioxidant-rich foods may be acting as more than just oxygen radical neutralizers in the aging central nervous system.

SUMMARY

Antioxidant-rich berries consumed in the diet can positively impact learning and memory in the aged animal. This effect on cognition is thought to be due to the direct interaction of berry polyphenols with aging neurons, reducing the impact of stress-related cellular signals and increasing the capacity of neurons to maintain proper functioning during aging.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19057194

Citation

Willis, Lauren M., et al. "Recent Advances in Berry Supplementation and Age-related Cognitive Decline." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 1, 2009, pp. 91-4.
Willis LM, Shukitt-Hale B, Joseph JA. Recent advances in berry supplementation and age-related cognitive decline. Curr Opin Clin Nutr Metab Care. 2009;12(1):91-4.
Willis, L. M., Shukitt-Hale, B., & Joseph, J. A. (2009). Recent advances in berry supplementation and age-related cognitive decline. Current Opinion in Clinical Nutrition and Metabolic Care, 12(1), 91-4. https://doi.org/10.1097/MCO.0b013e32831b9c6e
Willis LM, Shukitt-Hale B, Joseph JA. Recent Advances in Berry Supplementation and Age-related Cognitive Decline. Curr Opin Clin Nutr Metab Care. 2009;12(1):91-4. PubMed PMID: 19057194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances in berry supplementation and age-related cognitive decline. AU - Willis,Lauren M, AU - Shukitt-Hale,Barbara, AU - Joseph,James A, PY - 2008/12/6/pubmed PY - 2009/2/12/medline PY - 2008/12/6/entrez SP - 91 EP - 4 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 12 IS - 1 N2 - PURPOSE OF REVIEW: To summarize recent findings and current concepts in the beneficial effects of berry consumption on brain function during aging. RECENT FINDINGS: Berryfruit supplementation has continued to demonstrate efficacy in reversing age-related cognitive decline in animal studies. In terms of the mechanisms behind the effects of berries on the central nervous system, recent studies have demonstrated the bioavailability of berry polyphenols in several animal models. These studies have revealed that flavonoids and polyphenols from berries do accumulate in the brain following long-term consumption. Finally, several compelling studies have revealed that berries can influence cell-signaling cascades both in vivo and in cell culture systems. These studies underscore the developing theory that berries and antioxidant-rich foods may be acting as more than just oxygen radical neutralizers in the aging central nervous system. SUMMARY: Antioxidant-rich berries consumed in the diet can positively impact learning and memory in the aged animal. This effect on cognition is thought to be due to the direct interaction of berry polyphenols with aging neurons, reducing the impact of stress-related cellular signals and increasing the capacity of neurons to maintain proper functioning during aging. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/19057194/Recent_advances_in_berry_supplementation_and_age_related_cognitive_decline_ L2 - https://doi.org/10.1097/MCO.0b013e32831b9c6e DB - PRIME DP - Unbound Medicine ER -