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Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol.
Scand J Gastroenterol 2009; 44(4):471-7SJ

Abstract

OBJECTIVE

The onset and progression of non-alcoholic fatty liver disease (NAFLD) seem to be affected by nutritive intake; however, detailed examinations have not been performed in non-obese NAFLD patients. The purpose of this study was to identify potential nutritive factors that affect NAFLD and its related nutritional problems.

MATERIAL AND METHODS

We investigated the distribution of abdominal fat, dietary intake, and biochemical data in patients with NAFLD and compared non-obese with obese patients.

RESULTS

There was no significant difference in the percentage of patients with diabetes or dyslipidemia between the obese and non-obese groups. Waist circumference, total abdominal fat levels, and subcutaneous fat levels were significantly higher in the obese group, while visceral fat levels were not significantly different between the two groups. Immunoreactive insulin (IRI) and homeostasis model assessment-insulin resistance (HOMA-IR) were significantly lower in the non-obese group, suggesting that the non-obese patients were not overtly insulin resistant. Although serum adiponectin and TNF-alpha levels were similar in both groups, leptin levels were significantly higher in the obese group. Total energy and carbohydrate intake tended to be higher in the obese group. A characteristic feature was that dietary cholesterol intake was significantly higher, while the intake of polyunsaturated fatty acids (PUFAs) was significantly lower in the non-obese group.

CONCLUSIONS

In non-obese NAFLD patients: 1) although visceral fat was increased, insulin resistance and/or dysregulated secretion of adipocytokines was not necessarily shown; 2) intakes of total energy and carbohydrates were not excessive, although dietary cholesterol was superabundant and dietary PUFAs were significantly lower compared with those in obese patients; and 3) characteristic fat intake may be associated with the formation of NAFLD.

Authors+Show Affiliations

Dietetic Laboratory, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19058085

Citation

Yasutake, Kenichiro, et al. "Nutritional Investigation of Non-obese Patients With Non-alcoholic Fatty Liver Disease: the Significance of Dietary Cholesterol." Scandinavian Journal of Gastroenterology, vol. 44, no. 4, 2009, pp. 471-7.
Yasutake K, Nakamuta M, Shima Y, et al. Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. Scand J Gastroenterol. 2009;44(4):471-7.
Yasutake, K., Nakamuta, M., Shima, Y., Ohyama, A., Masuda, K., Haruta, N., ... Enjoji, M. (2009). Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. Scandinavian Journal of Gastroenterology, 44(4), pp. 471-7. doi:10.1080/00365520802588133.
Yasutake K, et al. Nutritional Investigation of Non-obese Patients With Non-alcoholic Fatty Liver Disease: the Significance of Dietary Cholesterol. Scand J Gastroenterol. 2009;44(4):471-7. PubMed PMID: 19058085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol. AU - Yasutake,Kenichiro, AU - Nakamuta,Makoto, AU - Shima,Yuki, AU - Ohyama,Akiko, AU - Masuda,Kaori, AU - Haruta,Noriko, AU - Fujino,Tatsuya, AU - Aoyagi,Yoko, AU - Fukuizumi,Kunitaka, AU - Yoshimoto,Tsuyoshi, AU - Takemoto,Ryosuke, AU - Miyahara,Toshihiko, AU - Harada,Naohiko, AU - Hayata,Fukuko, AU - Nakashima,Manabu, AU - Enjoji,Munechika, PY - 2008/12/6/pubmed PY - 2009/6/17/medline PY - 2008/12/6/entrez SP - 471 EP - 7 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 44 IS - 4 N2 - OBJECTIVE: The onset and progression of non-alcoholic fatty liver disease (NAFLD) seem to be affected by nutritive intake; however, detailed examinations have not been performed in non-obese NAFLD patients. The purpose of this study was to identify potential nutritive factors that affect NAFLD and its related nutritional problems. MATERIAL AND METHODS: We investigated the distribution of abdominal fat, dietary intake, and biochemical data in patients with NAFLD and compared non-obese with obese patients. RESULTS: There was no significant difference in the percentage of patients with diabetes or dyslipidemia between the obese and non-obese groups. Waist circumference, total abdominal fat levels, and subcutaneous fat levels were significantly higher in the obese group, while visceral fat levels were not significantly different between the two groups. Immunoreactive insulin (IRI) and homeostasis model assessment-insulin resistance (HOMA-IR) were significantly lower in the non-obese group, suggesting that the non-obese patients were not overtly insulin resistant. Although serum adiponectin and TNF-alpha levels were similar in both groups, leptin levels were significantly higher in the obese group. Total energy and carbohydrate intake tended to be higher in the obese group. A characteristic feature was that dietary cholesterol intake was significantly higher, while the intake of polyunsaturated fatty acids (PUFAs) was significantly lower in the non-obese group. CONCLUSIONS: In non-obese NAFLD patients: 1) although visceral fat was increased, insulin resistance and/or dysregulated secretion of adipocytokines was not necessarily shown; 2) intakes of total energy and carbohydrates were not excessive, although dietary cholesterol was superabundant and dietary PUFAs were significantly lower compared with those in obese patients; and 3) characteristic fat intake may be associated with the formation of NAFLD. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/19058085/Nutritional_investigation_of_non_obese_patients_with_non_alcoholic_fatty_liver_disease:_the_significance_of_dietary_cholesterol_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365520802588133 DB - PRIME DP - Unbound Medicine ER -