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Chemiexcitation in the arachidonic acid cascade.
Photochem Photobiol 1991; 53(3):379-84PP

Abstract

As investigated in neutrophils, the very weak luminescence accompanying the arachidonic acid cascade is associated with the lipoxygenase pathway. The emission is dramatically enhanced by energy transfer to chlorophyll a. The number of chlorophyll molecules excited to the fluorescent state per oxygen consumed, (the S1/O2 ratio), equal to the product of the quantum yields of chemiexcitation and of energy transfer, is 5.4 x 10(-6). The quantum yield of chemiexcitation is inferred to be higher than 1 x 10(-3). The two most likely chemiexcitation routes point to triplet conjugated carbonyls as the most likely candidates for the excited species that transfer to chlorophyll. As such the emission intensity may reflect the level of hydroperoxyeicosatetraenoic acid. This is the first case where addition of a biotic substrate to a cellular system results in substantial generation of electronic excited states without any drastic loss of cell viability. Whether the formation of excited states in the arachidonic acid cascade in neutrophils is accidental or has a biological role is an open question.

Authors+Show Affiliations

Departamento de Bioquimica, Universidade de São Paulo, Brasil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1905821

Citation

Nascimento, A L., and G Cilento. "Chemiexcitation in the Arachidonic Acid Cascade." Photochemistry and Photobiology, vol. 53, no. 3, 1991, pp. 379-84.
Nascimento AL, Cilento G. Chemiexcitation in the arachidonic acid cascade. Photochem Photobiol. 1991;53(3):379-84.
Nascimento, A. L., & Cilento, G. (1991). Chemiexcitation in the arachidonic acid cascade. Photochemistry and Photobiology, 53(3), pp. 379-84.
Nascimento AL, Cilento G. Chemiexcitation in the Arachidonic Acid Cascade. Photochem Photobiol. 1991;53(3):379-84. PubMed PMID: 1905821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemiexcitation in the arachidonic acid cascade. AU - Nascimento,A L, AU - Cilento,G, PY - 1991/3/1/pubmed PY - 1991/3/1/medline PY - 1991/3/1/entrez SP - 379 EP - 84 JF - Photochemistry and photobiology JO - Photochem. Photobiol. VL - 53 IS - 3 N2 - As investigated in neutrophils, the very weak luminescence accompanying the arachidonic acid cascade is associated with the lipoxygenase pathway. The emission is dramatically enhanced by energy transfer to chlorophyll a. The number of chlorophyll molecules excited to the fluorescent state per oxygen consumed, (the S1/O2 ratio), equal to the product of the quantum yields of chemiexcitation and of energy transfer, is 5.4 x 10(-6). The quantum yield of chemiexcitation is inferred to be higher than 1 x 10(-3). The two most likely chemiexcitation routes point to triplet conjugated carbonyls as the most likely candidates for the excited species that transfer to chlorophyll. As such the emission intensity may reflect the level of hydroperoxyeicosatetraenoic acid. This is the first case where addition of a biotic substrate to a cellular system results in substantial generation of electronic excited states without any drastic loss of cell viability. Whether the formation of excited states in the arachidonic acid cascade in neutrophils is accidental or has a biological role is an open question. SN - 0031-8655 UR - https://www.unboundmedicine.com/medline/citation/1905821/Chemiexcitation_in_the_arachidonic_acid_cascade_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0031-8655&date=1991&volume=53&issue=3&spage=379 DB - PRIME DP - Unbound Medicine ER -