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Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain.
Brain Res. 2009 Jan 28; 1251:103-11.BR

Abstract

In this study, we evaluated the expression of MCP-1 in the rat dorsal root ganglion (DRG) and spinal cord following axotomy and chronic constriction injury (CCI) of the sciatic nerve and L5 spinal nerve ligation (L5 SNL) using an immunohistochemical approach. MCP-1 expression in the DRG peaked and declined before the full onset of pain hypersensitivity following nerve injury. Spinal expression of MCP-1 peaked when mechanical allodynia was maximal, but then declined rapidly despite the remarkable persistence of mechanical allodynia. The results suggest that MCP-1 may participate in the initiation of neuropathic pain, rather than in its maintenance. Despite increased MCP-1 in small and large DRG neurons, a remarkable increase in MCP-1-IR terminals was observed in the spinal superficial laminae following CCI and L5SNL, but not following axotomy; however, in the deeper laminae, a considerable increase in MCP-1-IR terminals, which may originate from the large and injured L5 DRG neurons, was found after L5 SNL. Our results demonstrate that MCP-1 synthesized in DRG neurons may or may not be transported to the spinal cord depending on the type of peripheral nerve injury. Additionally, increased MCP-1 in both intact L4 and injured L5 DRG neurons may contribute to neuropathic pain hypersensitivity following L5 SNL.

Authors+Show Affiliations

Department of Anatomy, School of Medicine, Kyungpook National University, 2-101, Dongin Dong, Daegu, 700-422, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19059387

Citation

Jeon, Sang-Min, et al. "Expression of Monocyte Chemoattractant Protein-1 in Rat Dorsal Root Ganglia and Spinal Cord in Experimental Models of Neuropathic Pain." Brain Research, vol. 1251, 2009, pp. 103-11.
Jeon SM, Lee KM, Cho HJ. Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. Brain Res. 2009;1251:103-11.
Jeon, S. M., Lee, K. M., & Cho, H. J. (2009). Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. Brain Research, 1251, 103-11. https://doi.org/10.1016/j.brainres.2008.11.046
Jeon SM, Lee KM, Cho HJ. Expression of Monocyte Chemoattractant Protein-1 in Rat Dorsal Root Ganglia and Spinal Cord in Experimental Models of Neuropathic Pain. Brain Res. 2009 Jan 28;1251:103-11. PubMed PMID: 19059387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. AU - Jeon,Sang-Min, AU - Lee,Kyung-Min, AU - Cho,Hee-Jung, Y1 - 2008/11/27/ PY - 2008/09/22/received PY - 2008/11/14/revised PY - 2008/11/14/accepted PY - 2008/12/9/pubmed PY - 2009/4/21/medline PY - 2008/12/9/entrez SP - 103 EP - 11 JF - Brain research JO - Brain Res VL - 1251 N2 - In this study, we evaluated the expression of MCP-1 in the rat dorsal root ganglion (DRG) and spinal cord following axotomy and chronic constriction injury (CCI) of the sciatic nerve and L5 spinal nerve ligation (L5 SNL) using an immunohistochemical approach. MCP-1 expression in the DRG peaked and declined before the full onset of pain hypersensitivity following nerve injury. Spinal expression of MCP-1 peaked when mechanical allodynia was maximal, but then declined rapidly despite the remarkable persistence of mechanical allodynia. The results suggest that MCP-1 may participate in the initiation of neuropathic pain, rather than in its maintenance. Despite increased MCP-1 in small and large DRG neurons, a remarkable increase in MCP-1-IR terminals was observed in the spinal superficial laminae following CCI and L5SNL, but not following axotomy; however, in the deeper laminae, a considerable increase in MCP-1-IR terminals, which may originate from the large and injured L5 DRG neurons, was found after L5 SNL. Our results demonstrate that MCP-1 synthesized in DRG neurons may or may not be transported to the spinal cord depending on the type of peripheral nerve injury. Additionally, increased MCP-1 in both intact L4 and injured L5 DRG neurons may contribute to neuropathic pain hypersensitivity following L5 SNL. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19059387/Expression_of_monocyte_chemoattractant_protein_1_in_rat_dorsal_root_ganglia_and_spinal_cord_in_experimental_models_of_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(08)02828-X DB - PRIME DP - Unbound Medicine ER -