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Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats.
Chem Biol Interact. 2009 May 15; 179(2-3):356-62.CB

Abstract

Resveratrol, a ubiquitous stress-induced phytoalexin, has demonstrated a wide variety of biological activities which make it a good candidate for the treatment of diabetes mellitus. The present study was aimed to evaluate its therapeutic potential by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. The daily oral treatment of resveratrol (5 mg/kg body weight) to diabetic rats for 30 days demonstrated a significant (p<0.05) decline in blood glucose and glycosylated hemoglobin levels and a significant (p<0.05) increase in plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver and kidney tissues of diabetic rats were significantly (p<0.05) reverted to near normal levels by the administration of resveratrol. Further, resveratrol administration to diabetic rats improved hepatic glycogen content suggesting the antihyperglycemic potential of resveratrol in diabetic rats. The obtained results were compared with glyclazide, a standard oral hypoglycemic drug. Thus, the modulatory effects of resveratrol on attenuating these enzymes activities afford a promise for widespread use for treatment of diabetes in the future.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Palsamy P
Research Scholar, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India.
Subramanian S
No affiliation info available

MeSH

Administration, OralAnimalsCarbohydrate MetabolismDiabetes Mellitus, ExperimentalDisease Models, AnimalDrug Evaluation, PreclinicalFructose-BisphosphataseGliclazideGlucose-6-PhosphataseGlucosephosphate DehydrogenaseGlycogen PhosphorylaseGlycogen SynthaseHexokinaseHypoglycemic AgentsKidneyL-Lactate DehydrogenaseLiverMaleNiacinamidePyruvate KinaseRatsRats, WistarResveratrolStilbenesStreptozocin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19059388

Citation

Palsamy, P, and S Subramanian. "Modulatory Effects of Resveratrol On Attenuating the Key Enzymes Activities of Carbohydrate Metabolism in Streptozotocin-nicotinamide-induced Diabetic Rats." Chemico-biological Interactions, vol. 179, no. 2-3, 2009, pp. 356-62.
Palsamy P, Subramanian S. Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chem Biol Interact. 2009;179(2-3):356-62.
Palsamy, P., & Subramanian, S. (2009). Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Chemico-biological Interactions, 179(2-3), 356-62. https://doi.org/10.1016/j.cbi.2008.11.008
Palsamy P, Subramanian S. Modulatory Effects of Resveratrol On Attenuating the Key Enzymes Activities of Carbohydrate Metabolism in Streptozotocin-nicotinamide-induced Diabetic Rats. Chem Biol Interact. 2009 May 15;179(2-3):356-62. PubMed PMID: 19059388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. AU - Palsamy,P, AU - Subramanian,S, Y1 - 2008/11/19/ PY - 2008/10/08/received PY - 2008/11/08/revised PY - 2008/11/10/accepted PY - 2008/12/9/pubmed PY - 2009/5/7/medline PY - 2008/12/9/entrez SP - 356 EP - 62 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 179 IS - 2-3 N2 - Resveratrol, a ubiquitous stress-induced phytoalexin, has demonstrated a wide variety of biological activities which make it a good candidate for the treatment of diabetes mellitus. The present study was aimed to evaluate its therapeutic potential by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. The daily oral treatment of resveratrol (5 mg/kg body weight) to diabetic rats for 30 days demonstrated a significant (p<0.05) decline in blood glucose and glycosylated hemoglobin levels and a significant (p<0.05) increase in plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver and kidney tissues of diabetic rats were significantly (p<0.05) reverted to near normal levels by the administration of resveratrol. Further, resveratrol administration to diabetic rats improved hepatic glycogen content suggesting the antihyperglycemic potential of resveratrol in diabetic rats. The obtained results were compared with glyclazide, a standard oral hypoglycemic drug. Thus, the modulatory effects of resveratrol on attenuating these enzymes activities afford a promise for widespread use for treatment of diabetes in the future. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/19059388/Modulatory_effects_of_resveratrol_on_attenuating_the_key_enzymes_activities_of_carbohydrate_metabolism_in_streptozotocin_nicotinamide_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -
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