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Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study.
Metabolism. 2009 Jan; 58(1):22-9.M

Abstract

Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52, n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR >or=3.52, n = 224): 11.02 +/- 0.27 microg/mL vs 8.26 +/- 0.32 microg/mL, P < .001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age, and body mass index. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist circumference, and insulin and triglycerides concentrations in Yup'ik women.

Authors+Show Affiliations

Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775-7000, USA. fnag@uaf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19059527

Citation

Goropashnaya, Anna V., et al. "Relationships Between Plasma Adiponectin and Body Fat Distribution, Insulin Sensitivity, and Plasma Lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research Study." Metabolism: Clinical and Experimental, vol. 58, no. 1, 2009, pp. 22-9.
Goropashnaya AV, Herron J, Sexton M, et al. Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism. 2009;58(1):22-9.
Goropashnaya, A. V., Herron, J., Sexton, M., Havel, P. J., Stanhope, K. L., Plaetke, R., Mohatt, G. V., & Boyer, B. B. (2009). Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. Metabolism: Clinical and Experimental, 58(1), 22-9. https://doi.org/10.1016/j.metabol.2008.09.002
Goropashnaya AV, et al. Relationships Between Plasma Adiponectin and Body Fat Distribution, Insulin Sensitivity, and Plasma Lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research Study. Metabolism. 2009;58(1):22-9. PubMed PMID: 19059527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between plasma adiponectin and body fat distribution, insulin sensitivity, and plasma lipoproteins in Alaskan Yup'ik Eskimos: the Center for Alaska Native Health Research study. AU - Goropashnaya,Anna V, AU - Herron,Johanna, AU - Sexton,Mary, AU - Havel,Peter J, AU - Stanhope,Kimber L, AU - Plaetke,Rosemarie, AU - Mohatt,Gerald V, AU - Boyer,Bert B, PY - 2008/12/9/pubmed PY - 2009/1/16/medline PY - 2008/12/9/entrez SP - 22 EP - 9 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 1 N2 - Adiponectin, a protein secreted by adipose tissue, has antiatherogenic, anti-inflammatory, and insulin-sensitizing actions. We examined the relationship between plasma adiponectin and adiposity, insulin resistance, plasma lipids, glucose, leptin, and anthropometric measurements in 316 adult men and 353 adult women Yup'ik Eskimos in Southwest Alaska. Adiponectin concentration was negatively associated with body mass index, percentage of body fat, sum of skin folds, waist circumference, triglycerides, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), fasting insulin, and leptin in both men and women, and also with glucose in women. Adiponectin concentration correlated positively with high-density lipoprotein cholesterol concentration, and also with low-density lipoprotein cholesterol in women. Insulin-sensitive individuals (HOMA-IR <3.52, n = 442) had higher plasma adiponectin concentrations than more insulin-resistant individuals (HOMA-IR >or=3.52, n = 224): 11.02 +/- 0.27 microg/mL vs 8.26 +/- 0.32 microg/mL, P < .001. Adiponectin concentrations did not differ between groups of participants with low and high level of risk for developing coronary heart disease. No difference in plasma adiponectin levels was found among Yup'ik Eskimos and whites matched for sex, age, and body mass index. In conclusion, circulating adiponectin concentrations were most strongly associated with sum of skin folds in Yup'ik men and with high-density lipoprotein cholesterol levels, sum of skin folds, waist circumference, and insulin and triglycerides concentrations in Yup'ik women. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19059527/Relationships_between_plasma_adiponectin_and_body_fat_distribution_insulin_sensitivity_and_plasma_lipoproteins_in_Alaskan_Yup'ik_Eskimos:_the_Center_for_Alaska_Native_Health_Research_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00313-2 DB - PRIME DP - Unbound Medicine ER -